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Bromelain (pharmacology)

Bromelain, a concentrate of proteolytic enzymes from the pineapple plant, is used in medicine. It is approved in the European Union for the debridement (removal of eschar, that is dead and damaged tissue) of severe burn wounds under the brand name Nexobrid. It was developed by MediWound.

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Interactions

CYP2C8CYP2C9AmiodaroneChloroquineIbuprofen
6 related topics

Medical uses

GelIndicatedSkin transplantsRandomized controlled trialParaffin
5 related topics

Chemistry

Polyacrylic acidGelling agentDisodium hydrogen phosphateSodium hydroxideBuffer
5 related topics

Contraindications and adverse effects

PapainFever
2 related topics

Key facts & relationships

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AHFS/Drugs.com
UK Drug Information
ATC code
D03BA03 (WHO)
CAS Number
37189-34-7
ChemSpider
none
CompTox Dashboard (EPA)
DTXSID901010881
DrugBank
DB12249

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Overview

Medical uses

Contraindications and adverse effects

Interactions

Chemistry

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Map overview Semantic statistics

Bromelain (pharmacology)

Nodes33
Edges32
Triples19
Avg. degree1.94
Density0.060606
Components1

How this topic connects Entity context

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Bromelain (pharmacology)

Top relations

Legal status · 4
Bromelain (pharmacology) → EU: Rx-only, In general: ℞ (Prescription only), UK: POM (Prescription only), US: ℞-only
AHFS/Drugs.com · 1
Bromelain (pharmacology) → UK Drug Information
ATC code · 1
Bromelain (pharmacology) → D03BA03 (WHO)
CAS Number · 1
Bromelain (pharmacology) → 37189-34-7
ChemSpider · 1
Bromelain (pharmacology) → none
CompTox Dashboard (EPA) · 1
Bromelain (pharmacology) → DTXSID901010881
DrugBank · 1
Bromelain (pharmacology) → DB12249
ECHA InfoCard · 1
Bromelain (pharmacology) → 100.029.599
Elimination half-life · 1
Bromelain (pharmacology) → 11.7±3.5 (8.5–19.9) hrs
KEGG · 1
Bromelain (pharmacology) → D03162

Important terminology Word statistics

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Important terminology

bromelain nexobrid enzymes gel burns studies approved concentrate proteolytic pineapple medicine european effects medical 19 drug status anacaulase-bcdb debridement eschar

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Bromelain (pharmacology)AHFS/Drugs.comUK Drug Information1.00infobox
Bromelain (pharmacology)ATC codeD03BA03 (WHO)1.00infobox
Bromelain (pharmacology)CAS Number37189-34-71.00infobox
Bromelain (pharmacology)ChemSpidernone1.00infobox
Bromelain (pharmacology)CompTox Dashboard (EPA)DTXSID9010108811.00infobox
Bromelain (pharmacology)DrugBankDB122491.00infobox
Bromelain (pharmacology)ECHA InfoCard100.029.5991.00infobox
Bromelain (pharmacology)Elimination half-life11.7±3.5 (8.5–19.9) hrs1.00infobox
Bromelain (pharmacology)KEGGD031621.00infobox
Bromelain (pharmacology)Legal statusUK: POM (Prescription only)1.00infobox
Bromelain (pharmacology)Legal statusUS: ℞-only1.00infobox
Bromelain (pharmacology)Legal statusEU: Rx-only1.00infobox
Bromelain (pharmacology)Legal statusIn general: ℞ (Prescription only)1.00infobox
Bromelain (pharmacology)License dataUS DailyMed: Anacaulase1.00infobox
Bromelain (pharmacology)Other namesAnacaulase-bcdb1.00infobox
Bromelain (pharmacology)Protein binding~50% (bromelain)1.00infobox
Bromelain (pharmacology)Routes of administrationTopical1.00infobox
Bromelain (pharmacology)Trade namesNexobrid1.00infobox
Bromelain (pharmacology)UNIIZLM4P8929R1.00infobox

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