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Mitragynine

Mitragynine is an indole-based alkaloid and is one of the main psychoactive constituents in the Southeast Asian plant Mitragyna speciosa, commonly known as kratom. It has also been researched for its use to potentially manage symptoms of opioid withdrawal. It is a partial agonist of the μ-opioid receptors; and as such can produce effects similar to those…

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3D model (JSmol)
Interactive image
ATC code
None
Bioavailability
21%
CAS Number
4098-40-2
ChEBI
CHEBI:6956
ChEMBL
ChEMBL299031

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Overview

Uses

Adverse effects

Pharmacology

History

Society and culture

Research

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Map overview Semantic statistics

Mitragynine

Nodes91
Edges90
Triples101
Avg. degree1.98
Density0.021978
Components1

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Mitragynine

Top relations

related to Legal status in the United States · 16
Mitragynine → As, DEA, Despite, FDA, Following, House, In, In August, June, Kratom, October, Representatives, Schedule, This, United States, White House
related to Medical · 10
Mitragynine → April, As, Drug Addiction, Drug Administration, Drugs, EMCDDA, European Monitoring Centre, FDA, This, US Food
Legal status · 9
Mitragynine → AU: S8 (Controlled drug), BR: Class B1 (Psychoactive drugs), CA: Unscheduled, DE: NpSG (Industrial and scientific use only), NZ: Unscheduled, SE: Förteckning I, UK: Under Psychoactive Substances Act, UN: Unscheduled, US: Unscheduled
related to history · 7
Mitragynine → Americas, Europe, Indonesia, Recently, Southeast Asian, Thailand, While
related to Pharmacodynamics · 6
Mitragynine → Additionally, CNS, D2, However, In, The
related to Pharmacokinetics · 6
Mitragynine → However, In, Kratom, Owing, Pharmacokinetic, Tmax
related to Recreational · 6
Mitragynine → At, Consumption, CPP, Effects, OH, The
related to Research limitations · 5
Mitragynine → Additionally, Conversely, Experimental, Inconsistencies, More
related to Toxicology · 5
Mitragynine → Due, Fatalities, P450, Post-mortem, These
is a · 3
Mitragynine → indole-based alkaloid and is one of the main psychoactive constituents in the Southeast Asian plant Mitragyna speciosa, most abundant active alkaloid in kratom, most abundant component

Important terminology Word statistics

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Important terminology

kratom use opioid effects withdrawal alkaloid alkaloids receptors humans 7-hydroxymitragynine drug opioids study plant active concentration total research pain dea

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Mitragynine3D model (JSmol)Interactive image1.00infobox
MitragynineATC codeNone1.00infobox
MitragynineBioavailability21%1.00infobox
MitragynineCAS Number4098-40-21.00infobox
MitragynineChEBICHEBI:69561.00infobox
MitragynineChEMBLChEMBL2990311.00infobox
MitragynineChemSpider22988651.00infobox
MitragynineCompTox Dashboard (EPA)DTXSID7010321401.00infobox
MitragynineDrug classOpioid1.00infobox
MitragynineElimination half-life7–39 hours1.00infobox
MitragynineFormulaC23H30N2O41.00infobox
MitragynineKEGGC092261.00infobox
MitragynineLegal statusAU: S8 (Controlled drug)1.00infobox
MitragynineLegal statusBR: Class B1 (Psychoactive drugs)1.00infobox
MitragynineLegal statusCA: Unscheduled1.00infobox
MitragynineLegal statusDE: NpSG (Industrial and scientific use only)1.00infobox
MitragynineLegal statusNZ: Unscheduled1.00infobox
MitragynineLegal statusUK: Under Psychoactive Substances Act1.00infobox
MitragynineLegal statusUS: Unscheduled1.00infobox
MitragynineLegal statusUN: Unscheduled1.00infobox
MitragynineLegal statusSE: Förteckning I1.00infobox
MitragynineMelting point102–106 °C1.00infobox
MitragynineMetabolites7-Hydroxymitragynine1.00infobox
MitragynineMolar mass398.503 g·mol−11.00infobox
MitragynineOther names(–)-Mitragynine1.00infobox
MitragyninePubChem CID30343961.00infobox
MitragynineRoutes of administrationBy mouth1.00infobox
MitragynineUNIIEP479K822J1.00infobox
Mitragynineis aindole-based alkaloid and is one of the main psychoactive constituents in the Southeast Asian plant Mitragyna speciosa0.90text
Mitragynineis amost abundant active alkaloid in kratom0.90text

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