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Mitragynine: History, Community, Culture & Applications

Mitragynine is an indole-based alkaloid and is one of the main psychoactive constituents in the Southeast Asian plant Mitragyna speciosa, commonly known as kratom. It has also been researched for its use to potentially manage symptoms of opioid withdrawal. It is a partial agonist of the μ-opioid receptors; and as such can produce effects similar to those…

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Mitragynine topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Mitragynine. 1 topic appears in more than one source area, which can help identify connections that are less obvious in a linear reading.

Related topics
82
Source areas
7
Connected nodes
90
Extracted relationships
101
Concept neighborhoods
26
Bridge connections
90

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 39 topics
Pharmacology · 20 topics
Uses · 10 topics
Society and culture · 6 topics
Research · 4 topics
Adverse effects · 2 topics
History · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
ATC code
None
Bioavailability
21%
CAS Number
4098-40-2
ChEBI
CHEBI:6956
ChEMBL
ChEMBL299031

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Uses

Adverse effects

Pharmacology

History

Society and culture

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Mitragynine connects Entity context

The extracted context around Mitragynine shows recurring relationship patterns in the source. For example, Mitragynine → As, DEA, Despite, FDA, Following, House, In, In August, June, Kratom, October, Representatives, Schedule, This, United States, White House Another extracted example is Mitragynine → April, As, Drug Addiction, Drug Administration, Drugs, EMCDDA, European Monitoring Centre, FDA, This, US Food. Use these groups to spot repeated connection types before inspecting the individual relationships.

Mitragynine

Top relations

related to Legal status in the United States · 16
Mitragynine → As, DEA, Despite, FDA, Following, House, In, In August, June, Kratom, October, Representatives, Schedule, This, United States, White House
related to Medical · 10
Mitragynine → April, As, Drug Addiction, Drug Administration, Drugs, EMCDDA, European Monitoring Centre, FDA, This, US Food
Legal status · 9
Mitragynine → AU: S8 (Controlled drug), BR: Class B1 (Psychoactive drugs), CA: Unscheduled, DE: NpSG (Industrial and scientific use only), NZ: Unscheduled, SE: Förteckning I, UK: Under Psychoactive Substances Act, UN: Unscheduled, US: Unscheduled
related to history · 7
Mitragynine → Americas, Europe, Indonesia, Recently, Southeast Asian, Thailand, While
related to Pharmacodynamics · 6
Mitragynine → Additionally, CNS, D2, However, In, The
related to Pharmacokinetics · 6
Mitragynine → However, In, Kratom, Owing, Pharmacokinetic, Tmax
related to Recreational · 6
Mitragynine → At, Consumption, CPP, Effects, OH, The
related to Research limitations · 5
Mitragynine → Additionally, Conversely, Experimental, Inconsistencies, More
related to Toxicology · 5
Mitragynine → Due, Fatalities, P450, Post-mortem, These
is a · 3
Mitragynine → indole-based alkaloid and is one of the main psychoactive constituents in the Southeast Asian plant Mitragyna speciosa, most abundant active alkaloid in kratom, most abundant component

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

kratom use opioid effects withdrawal alkaloid alkaloids receptors humans 7-hydroxymitragynine drug opioids study plant active concentration total research pain dea

Mitragynine relationships Subject–Predicate–Object triples

TTTA extracted 101 structured relationships around Mitragynine. Examples in this analysis include Mitragynine → 3D model (JSmol) → Interactive image and Mitragynine → ATC code → None. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Mitragynine3D model (JSmol)Interactive image1.00infobox
MitragynineATC codeNone1.00infobox
MitragynineBioavailability21%1.00infobox
MitragynineCAS Number4098-40-21.00infobox
MitragynineChEBICHEBI:69561.00infobox
MitragynineChEMBLChEMBL2990311.00infobox
MitragynineChemSpider22988651.00infobox
MitragynineCompTox Dashboard (EPA)DTXSID7010321401.00infobox
MitragynineDrug classOpioid1.00infobox
MitragynineElimination half-life7–39 hours1.00infobox
MitragynineFormulaC23H30N2O41.00infobox
MitragynineKEGGC092261.00infobox
MitragynineLegal statusAU: S8 (Controlled drug)1.00infobox
MitragynineLegal statusBR: Class B1 (Psychoactive drugs)1.00infobox
MitragynineLegal statusCA: Unscheduled1.00infobox
MitragynineLegal statusDE: NpSG (Industrial and scientific use only)1.00infobox
MitragynineLegal statusNZ: Unscheduled1.00infobox
MitragynineLegal statusUK: Under Psychoactive Substances Act1.00infobox
MitragynineLegal statusUS: Unscheduled1.00infobox
MitragynineLegal statusUN: Unscheduled1.00infobox
MitragynineLegal statusSE: Förteckning I1.00infobox
MitragynineMelting point102–106 °C1.00infobox
MitragynineMetabolites7-Hydroxymitragynine1.00infobox
MitragynineMolar mass398.503 g·mol−11.00infobox
MitragynineOther names(–)-Mitragynine1.00infobox
MitragyninePubChem CID30343961.00infobox
MitragynineRoutes of administrationBy mouth1.00infobox
MitragynineUNIIEP479K822J1.00infobox
Mitragynineis aindole-based alkaloid and is one of the main psychoactive constituents in the Southeast Asian plant Mitragyna speciosa0.90text
Mitragynineis amost abundant active alkaloid in kratom0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Mitragynine bring nearby vocabulary together. In this analysis, examples include Kratom, Use and Drug. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Mitragynine
    • Kratom
    • Use
    • Drug
    • Alkaloids
    • Humans
    • Receptors
    • Effects
    • 7-hydroxymitragynine
    • Known
    • Solubility
    • Plant
    • Report
  • mitragynine
    • Kratom
    • Use
    • Drug
    • Alkaloids
    • Humans
    • Receptors
    • Effects
    • 7-hydroxymitragynine
    • Known
    • Solubility
    • Plant
    • Report
  • kratom
    • Mitragynine
    • Alkaloids
    • Active
    • Research
    • Effects
    • 7-hydroxymitragynine
    • Pain
    • States
    • United
    • Plant
    • Opioid
    • Use
  • adverse effects
    • Metabolism
    • Drug
    • 7-hydroxymitragynine
    • Adverse
    • Effects
    • Use
    • Research
    • Also
    • Kratom
    • Known
    • Pain
    • Preparations
  • 7-hydroxymitragynine
    • Research
    • Effects
    • Also
    • Total
    • Adverse
    • Constituents
    • Dea
    • Metabolism
    • Pain
    • Solubility
    • States
    • United
  • opioid addiction
    • Withdrawal
    • Study
    • Use
    • Morphine
    • Animal
    • Agonist
    • 7-hydroxymitragynine
    • Adverse
    • Concentration
    • Metabolism
    • Opioids
    • Pain
  • opioid replacement
    • Withdrawal
    • Study
    • Use
    • Morphine
    • Animal
    • Agonist
    • 7-hydroxymitragynine
    • Adverse
    • Concentration
    • Metabolism
    • Opioids
    • Pain
  • withdrawal
    • Opioid
    • Use
    • Also
    • Morphine
    • Animal
    • Study
    • 7-hydroxymitragynine
    • Adverse
    • Metabolism
    • Opioids
    • Pain
    • Solubility

Connections between topic areas Semantic bridges

For Mitragynine, one of the stronger structural bridges in this analysis connects Mitragynine with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Mitragynine — Overview · splits 51 ⟂ 40
Mitragynine — Pharmacology · splits 70 ⟂ 21
Mitragynine — Uses · splits 80 ⟂ 11
Mitragynine — Society and culture · splits 84 ⟂ 7
Mitragynine — Research · splits 86 ⟂ 5
Mitragynine — Adverse effects · splits 88 ⟂ 3
Mitragynine — History · splits 88 ⟂ 3

Map overview Semantic statistics

Mitragynine

Nodes91
Edges90
Triples101
Avg. degree1.98
Density0.021978
Components1

Source & methodology

TTTA analyzes the structure around Mitragynine to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Mitragynine · EN edition · Analysis: TopicsToTalkAbout

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