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Revumenib

Revumenib, sold under the brand name Revuforj, is an anti-cancer medication used for the treatment of acute leukemias harboring lysine methyltransferase 2A gene (KMT2A) rearrangements. It is designed to disrupt the interaction between menin and KMT2A (also known as MLL), which plays a role in the pathogenesis of these leukemias. It is taken by mouth.

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L01XX87 (WHO)
CAS Number
2169919-21-3 · 2169919-22-4
ChEMBL
ChEMBL4650827 · ChEMBL4650278
ChemSpider
95502909

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Map overview Semantic statistics

Revumenib

Nodes26
Edges25
Triples58
Avg. degree1.92
Density0.076923
Components1

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Revumenib

Top relations

related to External links · 16
Revumenib → Archived, AUGMENT-101, Clinical, ClinicalTrials, Code C165776, December, Expanded Access Program, MLL/KMT2A Gene Rearrangement, NCI Drug Dictionary, NCI Thesaurus, NCT04065399, NCT05918913, NPM1 Mutation, R/R Leukemias Including Those, Study, With
related to history · 9
Revumenib → AUGMENT-101, Drug Administration, Efficacy, FDA, NCT04065399, Participants, R/R, SNDX-5613-0700, The US Food
related to Medical uses · 3
Revumenib → In October, KMT2A, NPM1
CAS Number · 2
Revumenib → 2169919-21-3, 2169919-22-4
ChEMBL · 2
Revumenib → ChEMBL4650278, ChEMBL4650827
DrugBank · 2
Revumenib → DB18515, DBSALT003460
KEGG · 2
Revumenib → D12728, D12729
UNII · 2
Revumenib → 75HI05N8HS, LZ0M43NNF2
related to Legal status · 2
Revumenib → November, United States
related to Names · 2
Revumenib → It, Revuforj

Important terminology Word statistics

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Important terminology

kmt2a treatment acute name us drug menin gene 2024 leukemias adverse medical revuforj administration leukemia lysine methyltransferase 2a differentiation syndrome

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Revumenib3D model (JSmol)Interactive image1.00infobox
RevumenibAHFS/Drugs.comMonograph1.00infobox
RevumenibATC codeL01XX87 (WHO)1.00infobox
RevumenibCAS Number2169919-21-31.00infobox
RevumenibCAS Number2169919-22-41.00infobox
RevumenibChEMBLChEMBL46508271.00infobox
RevumenibChEMBLChEMBL46502781.00infobox
RevumenibChemSpider955029091.00infobox
RevumenibDrug classAntineoplastic; menin inhibitor1.00infobox
RevumenibDrugBankDB185151.00infobox
RevumenibDrugBankDBSALT0034601.00infobox
RevumenibFormulaC32H47FN6O4S1.00infobox
RevumenibKEGGD127281.00infobox
RevumenibKEGGD127291.00infobox
RevumenibLegal statusUS: ℞-only1.00infobox
RevumenibLicense dataUS DailyMed: Revumenib1.00infobox
RevumenibMedlinePlusa6240771.00infobox
RevumenibMolar mass630.82 g·mol−11.00infobox
RevumenibOther namesSNDX-56131.00infobox
RevumenibPDB ligandOQ4 (PDBe, RCSB PDB)1.00infobox
RevumenibPronunciation/rɪˈvuːmɛnɪb/ rih-VOO-meh-nib1.00infobox
RevumenibPubChem CID1322126571.00infobox
RevumenibRoutes of administrationBy mouth1.00infobox
RevumenibTrade namesRevuforj1.00infobox
RevumenibUNIILZ0M43NNF21.00infobox
RevumenibUNII75HI05N8HS1.00infobox

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