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Revumenib: History, Community, Culture & Applications

Revumenib, sold under the brand name Revuforj, is an anti-cancer medication used for the treatment of acute leukemias harboring lysine methyltransferase 2A gene (KMT2A) rearrangements. It is designed to disrupt the interaction between menin and KMT2A (also known as MLL), which plays a role in the pathogenesis of these leukemias. It is taken by mouth.

Language: English [EN]
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Revumenib topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Revumenib.

Related topics
20
Source areas
5
Connected nodes
25
Extracted relationships
58
Concept neighborhoods
14
Bridge connections
25

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 9 topics
Adverse effects · 5 topics
History · 3 topics
Medical uses · 2 topics
Society and culture · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L01XX87 (WHO)
CAS Number
2169919-21-3 · 2169919-22-4
ChEMBL
ChEMBL4650827 · ChEMBL4650278
ChemSpider
95502909

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Adverse effects

History

Society and culture

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Revumenib connects Entity context

The extracted context around Revumenib shows recurring relationship patterns in the source. For example, Revumenib → Archived, AUGMENT-101, Clinical, ClinicalTrials, Code C165776, December, Expanded Access Program, MLL/KMT2A Gene Rearrangement, NCI Drug Dictionary, NCI Thesaurus, NCT04065399, NCT05918913, NPM1 Mutation, R/R Leukemias Including Those, Study, With Another extracted example is Revumenib → AUGMENT-101, Drug Administration, Efficacy, FDA, NCT04065399, Participants, R/R, SNDX-5613-0700, The US Food. Use these groups to spot repeated connection types before inspecting the individual relationships.

Revumenib

Top relations

related to External links · 16
Revumenib → Archived, AUGMENT-101, Clinical, ClinicalTrials, Code C165776, December, Expanded Access Program, MLL/KMT2A Gene Rearrangement, NCI Drug Dictionary, NCI Thesaurus, NCT04065399, NCT05918913, NPM1 Mutation, R/R Leukemias Including Those, Study, With
related to history · 9
Revumenib → AUGMENT-101, Drug Administration, Efficacy, FDA, NCT04065399, Participants, R/R, SNDX-5613-0700, The US Food
related to Medical uses · 3
Revumenib → In October, KMT2A, NPM1
CAS Number · 2
Revumenib → 2169919-21-3, 2169919-22-4
ChEMBL · 2
Revumenib → ChEMBL4650278, ChEMBL4650827
DrugBank · 2
Revumenib → DB18515, DBSALT003460
KEGG · 2
Revumenib → D12728, D12729
UNII · 2
Revumenib → 75HI05N8HS, LZ0M43NNF2
related to Legal status · 2
Revumenib → November, United States
related to Names · 2
Revumenib → It, Revuforj

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

kmt2a treatment acute name us drug menin gene 2024 leukemias adverse medical revuforj administration leukemia lysine methyltransferase 2a differentiation syndrome

Revumenib relationships Subject–Predicate–Object triples

TTTA extracted 58 structured relationships around Revumenib. Examples in this analysis include Revumenib → 3D model (JSmol) → Interactive image and Revumenib → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Revumenib3D model (JSmol)Interactive image1.00infobox
RevumenibAHFS/Drugs.comMonograph1.00infobox
RevumenibATC codeL01XX87 (WHO)1.00infobox
RevumenibCAS Number2169919-21-31.00infobox
RevumenibCAS Number2169919-22-41.00infobox
RevumenibChEMBLChEMBL46508271.00infobox
RevumenibChEMBLChEMBL46502781.00infobox
RevumenibChemSpider955029091.00infobox
RevumenibDrug classAntineoplastic; menin inhibitor1.00infobox
RevumenibDrugBankDB185151.00infobox
RevumenibDrugBankDBSALT0034601.00infobox
RevumenibFormulaC32H47FN6O4S1.00infobox
RevumenibKEGGD127281.00infobox
RevumenibKEGGD127291.00infobox
RevumenibLegal statusUS: ℞-only1.00infobox
RevumenibLicense dataUS DailyMed: Revumenib1.00infobox
RevumenibMedlinePlusa6240771.00infobox
RevumenibMolar mass630.82 g·mol−11.00infobox
RevumenibOther namesSNDX-56131.00infobox
RevumenibPDB ligandOQ4 (PDBe, RCSB PDB)1.00infobox
RevumenibPronunciation/rɪˈvuːmɛnɪb/ rih-VOO-meh-nib1.00infobox
RevumenibPubChem CID1322126571.00infobox
RevumenibRoutes of administrationBy mouth1.00infobox
RevumenibTrade namesRevuforj1.00infobox
RevumenibUNIILZ0M43NNF21.00infobox
RevumenibUNII75HI05N8HS1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Revumenib bring nearby vocabulary together. In this analysis, examples include Treatment, Medical and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Revumenib
    • Treatment
    • Medical
    • Gene
    • Kmt2a
    • Name
    • Acute
    • 2a
    • Administration
    • Leukemias
    • Lysine
    • Methyltransferase
    • Mutation
  • revumenib
    • Treatment
    • Medical
    • Gene
    • Kmt2a
    • Name
    • Acute
    • 2a
    • Administration
    • Leukemias
    • Lysine
    • Methyltransferase
    • Mutation
  • acute leukemias
    • Leukemia
    • Kmt2a
    • Mll
    • Treatment
    • 2a
    • Lysine
    • Methyltransferase
    • Refractory
    • Relapsed
    • Gene
    • Menin
    • Revuforj
  • kmt2a
    • Leukemias
    • Mll
    • Lysine
    • Menin
    • Methyltransferase
    • Revuforj
    • Name
    • Treatment
    • Legal
    • Names
    • Revumenib
    • Status
  • international nonproprietary name
    • Revuforj
    • Sold
    • 2a
    • Lysine
    • Methyltransferase
    • Gene
    • Kmt2a
    • Acute
    • Treatment
    • Legal
    • Names
    • Revumenib
  • adverse effects
    • Common
    • Reactions
    • Differentiation
    • Syndrome
    • Legal
    • Names
    • Status
    • Mouth
    • Administration
    • Lysine
    • Medical
    • Menin
  • food and drug administration
    • Administration
    • Drug
    • Us
    • Legal
    • Names
    • Status
    • Medication
    • Mouth
    • Adverse
    • Lysine
    • Medical
    • Menin
  • orphan drug
    • Administration
    • Us
    • Legal
    • Names
    • Status
    • Medication
    • Mouth
    • Lysine
    • Medical
    • Menin
    • Methyltransferase
    • Refractory

Connections between topic areas Semantic bridges

For Revumenib, one of the stronger structural bridges in this analysis connects Revumenib with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
RevumenibOverview · splits 16 ⟂ 10
RevumenibAdverse effects · splits 20 ⟂ 6
RevumenibHistory · splits 22 ⟂ 4
RevumenibMedical uses · splits 23 ⟂ 3

Map overview Semantic statistics

Revumenib

Nodes26
Edges25
Triples58
Avg. degree1.92
Density0.076923
Components1

Source & methodology

TTTA analyzes the structure around Revumenib to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Revumenib · EN edition · Analysis: TopicsToTalkAbout

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