Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

MECOM: Research, Association with cancer & Gene structure

MDS1 and EVI1 complex locus protein (MECOM) also known as ecotropic virus integration site 1 protein homolog (EVI-1) or positive regulatory domain zinc finger protein 3 (PRDM3) is a protein that in humans is encoded by the MECOM gene. MECOM was first identified as a common retroviral integration site in AKXD murine myeloid tumors. It has since been…

Language: English [EN]

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Map view:

Zoom: 100%

More settings

Connection length 100% Label size 100% Node size 100% Line width 100% Label width 100%

Export map as:

MECOM topic overview

The analysis highlights Research, Association with cancer and Gene structure as prominent areas in the source structure around MECOM.

Related topics: 55
Source areas: 6
Connected nodes: 61
Extracted relationships: 197
Concept neighborhoods: 22
Bridge connections: 61

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Association with cancer · 20 topics

Overview · 15 topics

Gene structure · 7 topics

Biological role · 6 topics

Interactions · 6 topics

Future and current research · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.1.1.367: ↗
Aliases: MECOM, AML1-EVI-1, EVI1, MDS1, MDS1-EVI1, PRDM3, RUSAT2, MDS1 and EVI1 complex locus, KMT8E
Band: 3q26.2 · 3 A3|3 12.66 cM
Bgee: cardia · renal medulla · pylorus · nasal epithelium · mucosa of paranasal sinus
BioGPS: More reference expression data
Chr.: Chromosome 3 (human) · Chromosome 3 (mouse)

Suggested research paths

A focused starting point derived from the topic graph, ranked independently of the source article order.

Start with these areas

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Protein
Gene
Retroviral
Transcription factor
Cell cycle
Transforming growth factor beta (TGF-β) TGF-b
Bone morphogenic protein (BMP) Bone morphogenetic protein
Activin
Cyclin-dependent kinase
Cellular differentiation
SMAD SMAD (protein)
SMAD2
SMAD3
TGF-β receptor TGF beta receptor
C-Jun N-terminal kinase

Gene structure

Biological role

Association with cancer

Acute myelogenous leukemia Acute myeloid leukemia
MDS Myelodysplastic syndrome
Chronic myelogenous leukemia Chronic myeloid leukemia
Prognosis
Phosphorylation
N-terminal N-terminus
Apoptosis
Yeast 2-hybrid Two-hybrid screening
Immunoprecipitation
As shown in the figure below As shown in the figure below?action=edit&redlink=1
3q21q26 syndrome 3q21q26 syndrome?action=edit&redlink=1
Ribophorin
RPN1
Acute myelogenous leukemia
Monosomy
Chromosome 7
Chromosome 5
BCR-Abl
Tyrosine kinase
Arsenic trioxide

Future and current research

Gene therapy

Interactions

Interact Protein-protein interaction
CREB binding protein
CTBP1
HDAC1
Mothers against decapentaplegic homolog 3
PCAF

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How MECOM connects Entity context

The extracted context around MECOM shows recurring relationship patterns in the source. For example, MECOM → apoptotic process, cell differentiation, cytoplasm, cytosol, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, hematopoietic stem cell proliferation, heterochromatin organization, histone deacetylase complex, histone H3-K9 methylation, histone lysine methylation, histone methyltransferase activity (H3-K9 specific), histone-lysine N-methyltransferase activity, metal ion binding, methylation, methyltransferase activity, multicellular organism development, negative regulation of JNK cascade, negative regulation of programmed cell death Another extracted example is MECOM → bronchial epithelial cell, cardia, ciliary body, endocardial cushion, epithelium of stomach, lacrimal gland, left colon, left lung lobe, lower lobe of lung, medullary collecting duct, mucosa of paranasal sinus, mucosa of sigmoid colon, mucosa of urinary bladder, nasal epithelium, Paneth cell, pylorus, renal corpuscle, renal medulla, transitional epithelium of urinary bladder, visceral pleura. Use these groups to spot repeated connection types before inspecting the individual relationships.

MECOM

Top relations

Gene ontology · 34

MECOM → apoptotic process, cell differentiation, cytoplasm, cytosol, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, hematopoietic stem cell proliferation, heterochromatin organization, histone deacetylase complex, histone H3-K9 methylation, histone lysine methylation, histone methyltransferase activity (H3-K9 specific), histone-lysine N-methyltransferase activity, metal ion binding, methylation, methyltransferase activity, multicellular organism development, negative regulation of JNK cascade, negative regulation of programmed cell death

Bgee · 20

MECOM → bronchial epithelial cell, cardia, ciliary body, endocardial cushion, epithelium of stomach, lacrimal gland, left colon, left lung lobe, lower lobe of lung, medullary collecting duct, mucosa of paranasal sinus, mucosa of sigmoid colon, mucosa of urinary bladder, nasal epithelium, Paneth cell, pylorus, renal corpuscle, renal medulla, transitional epithelium of urinary bladder, visceral pleura

RNA expression pattern · 20

has treatment · 11

MECOM → AML1/MDS1/MECOM, Arsenic, As, ATO, However, If, II, It, One, Phase, Very

related to Epigenetics · 9

MECOM → C-terminal-binding, CtBP, CtBP-binding, DNA, HDACs, Smad3, TGF-β, The, This

related to mRNA · 9

MECOM → AME, AML1/MDS1/MECOM, C-terminus, ETV6/MDS1/MECOM, Fusion, MDS1/MECOM, ME, Rp9, Some

related to Association with cancer · 8

MECOM → All, AML, CML, It, Its, MDS, N-terminal DNA, Overexpression

related to Chromosome instability · 8

MECOM → DNA, Nucifora, One, Ribophorin, RPN1, Since, The, This

related to Oncogenesis and induced proliferation of HSCs · 7

MECOM → Among, GATA-2, However, HSC, HSCs, It, The

related to External links · 6

MECOM → Histone-lysine N-methyltransferase MECOM, Overview, PDB, PDBe-KB, Q03112, UniProt

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

transcription cell human shown gene protein binding cells tgf-β role chromosome expression factor signaling nucleus development proliferation cycle also many

MECOM relationships Subject–Predicate–Object triples

TTTA extracted 197 structured relationships around MECOM. Examples in this analysis include MECOM → 2.1.1.367 → ↗ and MECOM → Aliases → MECOM, AML1-EVI-1, EVI1, MDS1, MDS1-EVI1, PRDM3, RUSAT2, MDS1 and EVI1 complex locus, KMT8E. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
MECOM	2.1.1.367	↗	1.00	infobox
MECOM	Aliases	MECOM, AML1-EVI-1, EVI1, MDS1, MDS1-EVI1, PRDM3, RUSAT2, MDS1 and EVI1 complex locus, KMT8E	1.00	infobox
MECOM	Band	3q26.2	1.00	infobox
MECOM	Band	3 A3\|3 12.66 cM	1.00	infobox
MECOM	Bgee	cardia	1.00	infobox
MECOM	Bgee	renal medulla	1.00	infobox
MECOM	Bgee	pylorus	1.00	infobox
MECOM	Bgee	nasal epithelium	1.00	infobox
MECOM	Bgee	mucosa of paranasal sinus	1.00	infobox
MECOM	Bgee	bronchial epithelial cell	1.00	infobox
MECOM	Bgee	visceral pleura	1.00	infobox
MECOM	Bgee	mucosa of urinary bladder	1.00	infobox
MECOM	Bgee	mucosa of sigmoid colon	1.00	infobox
MECOM	Bgee	lower lobe of lung	1.00	infobox
MECOM	Bgee	transitional epithelium of urinary bladder	1.00	infobox
MECOM	Bgee	epithelium of stomach	1.00	infobox
MECOM	Bgee	Paneth cell	1.00	infobox
MECOM	Bgee	left lung lobe	1.00	infobox
MECOM	Bgee	renal corpuscle	1.00	infobox
MECOM	Bgee	medullary collecting duct	1.00	infobox
MECOM	Bgee	endocardial cushion	1.00	infobox
MECOM	Bgee	left colon	1.00	infobox
MECOM	Bgee	lacrimal gland	1.00	infobox
MECOM	Bgee	ciliary body	1.00	infobox
MECOM	BioGPS	More reference expression data	1.00	infobox
MECOM	Chr.	Chromosome 3 (human)	1.00	infobox
MECOM	Chr.	Chromosome 3 (mouse)	1.00	infobox
MECOM	Databases	NCBI: entry; OMA: entry	1.00	infobox
MECOM	End	169,663,775 bp	1.00	infobox
MECOM	End	30,602,157 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around MECOM bring nearby vocabulary together. In this analysis, examples include Shown, Cell and Expression. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

MECOM
- Shown
- Cell
- Expression
- Protein
- Role
- Transcription
- Interaction
- Binding
- Positive
- However
- Jnk
- Specific
mecom
- Shown
- Cell
- Expression
- Protein
- Role
- Transcription
- Interaction
- Binding
- Positive
- However
- Jnk
- Specific
gene
- Bp
- Chr
- Chromosome
- Human
- Signaling
- Band
- Protein
- Mouse
- Positive
- Cycle
- Jnk
- Proliferation
transcription factor
- Binding
- Cycle
- Dna
- Signaling
- Factor
- Transcription
- Development
- Cell
- Nucleus
- Tgf-β
- Tumor
- Jnk
cell cycle
- Cycle
- Signaling
- Proliferation
- Jnk
- Factor
- Role
- Tgf-β
- Bp
- Chr
- Mecom
- Apoptosis
- Chromosome
transforming growth factor beta (tgf-β)
- Cycle
- Transcription
- Signaling
- Development
- Cell
- Tumor
- Jnk
- Specific
- Dna
- Interaction
- Many
- Differentiation
chromosome 3
- Bp
- Chr
- Band
- Human
- Gene
- Complex
- Mouse
- Cycle
- Jnk
- Dna
- Proliferation
- Signaling
chimeric gene
- Bp
- Chr
- Chromosome
- Human
- Signaling
- Band
- Protein
- Mouse
- Positive
- Cycle
- Jnk
- Proliferation

Connections between topic areas Semantic bridges

For MECOM, one of the stronger structural bridges in this analysis connects MECOM with Association with cancer. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

MECOM — Association with cancer · splits 41 ⟂ 21

MECOM — Overview · splits 46 ⟂ 16

MECOM — Gene structure · splits 54 ⟂ 8

MECOM — Biological role · splits 55 ⟂ 7

MECOM — Interactions · splits 55 ⟂ 7

Map overview Semantic statistics

MECOM

Nodes62

Edges61

Triples197

Avg. degree1.97

Density0.032258

Components1

Source & methodology

TTTA analyzes the structure around MECOM to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Research, Association with cancer & Gene structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — MECOM · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.