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MALT1: Function, Protease inhibitors & Interactions

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 is a protein that in humans is encoded by the MALT1 gene. It is the human paracaspase.

Language: English [EN]
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MALT1 topic overview

The analysis highlights Function, Protease inhibitors and Interactions as prominent areas in the source structure around MALT1.

Related topics
56
Source areas
5
Connected nodes
61
Extracted relationships
143
Concept neighborhoods
14
Bridge connections
61

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Protease inhibitors · 24 topics
Function · 23 topics
Interactions · 3 topics
Overview · 3 topics
Protease substrates · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
MALT1, IMD12, MLT, MLT1, PCASP1, MALT1 paracaspase
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2G7R, 3BFO, 3K0W, 3UO8, 3UOA, 3V4O, 3V55, 4I1P, 4I1R
Band
18q21.32 · 18|18 E1
Bgee
epithelium of colon · tonsil · testicle · Achilles tendon · monocyte
BioGPS
More reference expression data
Chr.
Chromosome 18 (human) · Chromosome 18 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Interactions

Protease substrates

Protease inhibitors

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How MALT1 connects Entity context

The extracted context around MALT1 shows recurring relationship patterns in the source. For example, MALT1 → activation of NF-kappaB-inducing kinase activity, B cell activation, B-1 B cell differentiation, CBM complex, cysteine-type endopeptidase activity, cytoplasm, cytosol, defense response, Fc-epsilon receptor signaling pathway, fibrillar center, hydrolase activity, identical protein binding, innate immune response, kinase activator activity, negative regulation of apoptotic process, nuclear export, nucleolus, nucleus, peptidase activity, perinuclear region of cytoplasm Another extracted example is MALT1 → AbbVie, ACS, Analogs, AstraZeneca, Biperiden, CD3, Centre, Chordia, Dictyosporium, Discovery, Drug Design, First Time Disclosure Session, Initially, Janssen Pharmaceutica, Lapachone, Leuven-based, Lupin, LVSR, MI-2, Novartis. Use these groups to spot repeated connection types before inspecting the individual relationships.

MALT1

Top relations

Gene ontology · 42
MALT1 → activation of NF-kappaB-inducing kinase activity, B cell activation, B-1 B cell differentiation, CBM complex, cysteine-type endopeptidase activity, cytoplasm, cytosol, defense response, Fc-epsilon receptor signaling pathway, fibrillar center, hydrolase activity, identical protein binding, innate immune response, kinase activator activity, negative regulation of apoptotic process, nuclear export, nucleolus, nucleus, peptidase activity, perinuclear region of cytoplasm
related to Protease inhibitors · 30
MALT1 → AbbVie, ACS, Analogs, AstraZeneca, Biperiden, CD3, Centre, Chordia, Dictyosporium, Discovery, Drug Design, First Time Disclosure Session, Initially, Janssen Pharmaceutica, Lapachone, Leuven-based, Lupin, LVSR, MI-2, Novartis
Bgee · 20
MALT1 → Achilles tendon, appendix, blood, buccal mucosa cell, epithelium of colon, genital tubercle, gonad, granulocyte, interventricular septum, lymph node, mesenteric lymph nodes, monocyte, muscle of thigh, neural layer of retina, spleen, stromal cell of endometrium, subcutaneous adipose tissue, tail of embryo, testicle, tonsil
RNA expression pattern · 20
MALT1 → Achilles tendon, appendix, blood, buccal mucosa cell, epithelium of colon, genital tubercle, gonad, granulocyte, interventricular septum, lymph node, mesenteric lymph nodes, monocyte, muscle of thigh, neural layer of retina, spleen, stromal cell of endometrium, subcutaneous adipose tissue, tail of embryo, testicle, tonsil
related to Protease substrates · 5
MALT1 → Currently, IAP2-MALT1, PCASP1, Since, Specifically
related to Interactions · 3
MALT1 → BCL10, SQSTM1/p62, TRAF6
Band · 2
MALT1 → 18q21.32, 18|18 E1
Chr. · 2
MALT1 → Chromosome 18 (human), Chromosome 18 (mouse)
End · 2
MALT1 → 58,754,477 bp, 65,612,138 bp
Aliases · 1
MALT1 → MALT1, IMD12, MLT, MLT1, PCASP1, MALT1 paracaspase

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

paracaspase protease activity inhibitors human bp gene nf-κb protein activation chr band substrates bcl10 shown inhibitor chromosome 18 mouse lymphocytes

MALT1 relationships Subject–Predicate–Object triples

TTTA extracted 143 structured relationships around MALT1. Examples in this analysis include MALT1 → Aliases → MALT1, IMD12, MLT, MLT1, PCASP1, MALT1 paracaspase and MALT1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2G7R, 3BFO, 3K0W, 3UO8, 3UOA, 3V4O, 3V55, 4I1P, 4I1R. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
MALT1AliasesMALT1, IMD12, MLT, MLT1, PCASP1, MALT1 paracaspase1.00infobox
MALT1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2G7R, 3BFO, 3K0W, 3UO8, 3UOA, 3V4O, 3V55, 4I1P, 4I1R1.00infobox
MALT1Band18q21.321.00infobox
MALT1Band18|18 E11.00infobox
MALT1Bgeeepithelium of colon1.00infobox
MALT1Bgeetonsil1.00infobox
MALT1Bgeetesticle1.00infobox
MALT1BgeeAchilles tendon1.00infobox
MALT1Bgeemonocyte1.00infobox
MALT1Bgeegonad1.00infobox
MALT1Bgeelymph node1.00infobox
MALT1Bgeebuccal mucosa cell1.00infobox
MALT1Bgeeappendix1.00infobox
MALT1Bgeestromal cell of endometrium1.00infobox
MALT1Bgeespleen1.00infobox
MALT1Bgeemesenteric lymph nodes1.00infobox
MALT1Bgeegranulocyte1.00infobox
MALT1Bgeetail of embryo1.00infobox
MALT1Bgeeblood1.00infobox
MALT1Bgeesubcutaneous adipose tissue1.00infobox
MALT1Bgeegenital tubercle1.00infobox
MALT1Bgeeneural layer of retina1.00infobox
MALT1Bgeeinterventricular septum1.00infobox
MALT1Bgeemuscle of thigh1.00infobox
MALT1BioGPSMore reference expression data1.00infobox
MALT1Chr.Chromosome 18 (human)1.00infobox
MALT1Chr.Chromosome 18 (mouse)1.00infobox
MALT1DatabasesNCBI: entry; OMA: entry1.00infobox
MALT1End58,754,477 bp1.00infobox
MALT1End65,612,138 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around MALT1 bring nearby vocabulary together. In this analysis, examples include Protease, Inhibitors and Activity. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • MALT1
    • Protease
    • Inhibitors
    • Activity
    • Gene
    • Protein
    • Substrates
    • Function
    • Like
    • Location
    • Paracaspase
    • Since
    • Tissue
  • malt1
    • Protease
    • Inhibitors
    • Activity
    • Gene
    • Protein
    • Substrates
    • Function
    • Like
    • Location
    • Paracaspase
    • Since
    • Tissue
  • protein
    • Tissue
    • Q9udy8
    • Uniprot
    • Binding
    • Bcl10
    • Gene
    • Activation
    • Paracaspase
    • Function
    • Pdb
    • Malt1
    • Crucial
  • gene
    • Location
    • Chromosome
    • Bp
    • Chr
    • Function
    • Human
    • Tissue
    • Band
    • Lymphocytes
    • Mouse
    • Production
    • Protein
  • paracaspase
    • Shown
    • Proteolytic
    • Substrates
    • Activity
    • Protein
    • Pdb
    • Q9udy8
    • Uniprot
    • Binding
    • Domain
    • Involved
    • Location
  • function
    • Location
    • Chromosome
    • External
    • Bp
    • Chr
    • Gene
    • Human
    • Pdb
    • Q9udy8
    • Uniprot
    • Binding
    • Crucial
  • protease substrates
    • Inhibitors
    • Activity
    • Involved
    • Since
    • Paracaspase
    • Protease
    • Substrates
    • External
    • Malt1
    • Function
    • Pdb
    • Like
  • protease inhibitors
    • Inhibitors
    • Protease
    • Malt1
    • Activity
    • Substrates
    • Like
    • Location
    • Since
    • Mouse
    • Protein
    • Activation
    • Inhibitor

Connections between topic areas Semantic bridges

For MALT1, one of the stronger structural bridges in this analysis connects MALT1 with Protease inhibitors. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
MALT1Protease inhibitors · splits 37 ⟂ 25
MALT1Function · splits 38 ⟂ 24
MALT1Overview · splits 58 ⟂ 4
MALT1Interactions · splits 58 ⟂ 4
MALT1Protease substrates · splits 58 ⟂ 4

Map overview Semantic statistics

MALT1

Nodes62
Edges61
Triples143
Avg. degree1.97
Density0.032258
Components1

Source & methodology

TTTA analyzes the structure around MALT1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Protease inhibitors & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — MALT1 · EN edition · Analysis: TopicsToTalkAbout

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