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MAD2L2: Interactions & Overview

Mitotic spindle assembly checkpoint protein MAD2B is a protein that in humans is encoded by the MAD2L2 gene.

Language: English [EN]
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MAD2L2 topic overview

The analysis highlights Interactions and Overview as prominent areas in the source structure around MAD2L2.

Related topics
7
Source areas
2
Connected nodes
9
Extracted relationships
105
Related term clusters
6
Bridge connections
9

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 5 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
MAD2L2, MAD2B, POLZ2, REV7, MAD2 mitotic arrest deficient-like 2 (yeast), mitotic arrest deficient 2 like 2, FANCV
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3ABD, 3ABE, 3VU7, 4EXT, 4GK0, 4GK5
Band
1p36.22 · 4|4 E2
Bgee
ganglionic eminence · left testis · right testis · granulocyte · gastrocnemius muscle
BioGPS
n/a
Chr.
Chromosome 1 (human) · Chromosome 4 (mouse)

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MAD2L2
7Protein · Gene · Protein-protein interaction

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Interactions

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How MAD2L2 connects Entity context

The extracted context around MAD2L2 shows recurring relationship patterns in the source. For example, MAD2L2 → actin filament organization, anaphase-promoting complex, cell cycle, cell division, cellular response to DNA damage stimulus, chromosome, cytoplasm, cytoskeleton, cytosol, DNA damage response, signal transduction resulting in transcription, DNA repair, double-strand break repair, error-prone translesion synthesis, JUN kinase binding, mitotic spindle assembly checkpoint signaling, negative regulation of canonical Wnt signaling pathway, negative regulation of cell-cell adhesion mediated by cadherin, negative regulation of DNA-binding transcription factor activity, negative regulation of double-strand break repair via homologous recombination, negative regulation of epithelial to mesenchymal transition Another extracted example is MAD2L2 → body of pancreas, external carotid artery, ganglionic eminence, gastrocnemius muscle, genital tubercle, granulocyte, left testis, morula, muscle of thigh, neural tube, right lobe of liver, right testis, secondary oocyte, seminiferous tubule, spermatocyte, stromal cell of endometrium, tail of embryo, ventricular zone, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

MAD2L2

Top relations

Gene ontology · 39
MAD2L2 → actin filament organization, anaphase-promoting complex, cell cycle, cell division, cellular response to DNA damage stimulus, chromosome, cytoplasm, cytoskeleton, cytosol, DNA damage response, signal transduction resulting in transcription, DNA repair, double-strand break repair, error-prone translesion synthesis, JUN kinase binding, mitotic spindle assembly checkpoint signaling, negative regulation of canonical Wnt signaling pathway, negative regulation of cell-cell adhesion mediated by cadherin, negative regulation of DNA-binding transcription factor activity, negative regulation of double-strand break repair via homologous recombination, negative regulation of epithelial to mesenchymal transition
Bgee · 19
MAD2L2 → body of pancreas, external carotid artery, ganglionic eminence, gastrocnemius muscle, genital tubercle, granulocyte, left testis, morula, muscle of thigh, neural tube, right lobe of liver, right testis, secondary oocyte, seminiferous tubule, spermatocyte, stromal cell of endometrium, tail of embryo, ventricular zone, zygote
RNA expression pattern · 19
MAD2L2 → body of pancreas, external carotid artery, ganglionic eminence, gastrocnemius muscle, genital tubercle, granulocyte, left testis, morula, muscle of thigh, neural tube, right lobe of liver, right testis, secondary oocyte, seminiferous tubule, spermatocyte, stromal cell of endometrium, tail of embryo, ventricular zone, zygote
related to Interactions · 3
MAD2L2 → ADAM9, MAD2L1, REV1
Band · 2
MAD2L2 → 1p36.22, 4|4 E2
Chr. · 2
MAD2L2 → Chromosome 1 (human), Chromosome 4 (mouse)
End · 2
MAD2L2 → 11,691,650 bp, 148,145,699 bp
Aliases · 1
MAD2L2 → MAD2L2, MAD2B, POLZ2, REV7, MAD2 mitotic arrest deficient-like 2 (yeast), mitotic arrest deficient 2 like 2, FANCV
Available structures · 1
MAD2L2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3ABD, 3ABE, 3VU7, 4EXT, 4GK0, 4GK5
BioGPS · 1
MAD2L2 → n/a

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp chr human chromosome band gene mitotic spindle assembly checkpoint location protein mouse mad2b function external search 691 650 end

MAD2L2 relationships Subject–Predicate–Object triples

TTTA extracted 105 structured relationships around MAD2L2. Examples in this analysis include MAD2L2 → Aliases → MAD2L2, MAD2B, POLZ2, REV7, MAD2 mitotic arrest deficient-like 2 (yeast), mitotic arrest deficient 2 like 2, FANCV and MAD2L2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3ABD, 3ABE, 3VU7, 4EXT, 4GK0, 4GK5. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
MAD2L2AliasesMAD2L2, MAD2B, POLZ2, REV7, MAD2 mitotic arrest deficient-like 2 (yeast), mitotic arrest deficient 2 like 2, FANCV1.00infobox
MAD2L2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3ABD, 3ABE, 3VU7, 4EXT, 4GK0, 4GK51.00infobox
MAD2L2Band1p36.221.00infobox
MAD2L2Band4|4 E21.00infobox
MAD2L2Bgeeganglionic eminence1.00infobox
MAD2L2Bgeeleft testis1.00infobox
MAD2L2Bgeeright testis1.00infobox
MAD2L2Bgeegranulocyte1.00infobox
MAD2L2Bgeegastrocnemius muscle1.00infobox
MAD2L2Bgeestromal cell of endometrium1.00infobox
MAD2L2Bgeeventricular zone1.00infobox
MAD2L2Bgeemuscle of thigh1.00infobox
MAD2L2Bgeeright lobe of liver1.00infobox
MAD2L2Bgeebody of pancreas1.00infobox
MAD2L2Bgeegenital tubercle1.00infobox
MAD2L2Bgeeseminiferous tubule1.00infobox
MAD2L2Bgeetail of embryo1.00infobox
MAD2L2Bgeespermatocyte1.00infobox
MAD2L2Bgeezygote1.00infobox
MAD2L2Bgeemorula1.00infobox
MAD2L2Bgeesecondary oocyte1.00infobox
MAD2L2Bgeeexternal carotid artery1.00infobox
MAD2L2Bgeeneural tube1.00infobox
MAD2L2BioGPSn/a1.00infobox
MAD2L2Chr.Chromosome 1 (human)1.00infobox
MAD2L2Chr.Chromosome 4 (mouse)1.00infobox
MAD2L2DatabasesNCBI: entry; OMA: entry1.00infobox
MAD2L2End11,691,650 bp1.00infobox
MAD2L2End148,145,699 bp1.00infobox
MAD2L2EnsemblENSG000001166701.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around MAD2L2 bring nearby vocabulary together. In this analysis, examples include Mitotic, Gene and External. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • gene
    • Location
    • Mitotic
    • Chromosome
    • Human
    • Bp
    • Chr
    • End
    • External
    • Function
    • Mad2b
    • Mad2l2
    • Mouse
  • MAD2L2
    • Mitotic
    • Gene
    • External
    • Function
    • Mad2l1
    • Protein
    • Search
    • Spindle
    • Location
    • Chromosome
    • Human
    • Bp
  • mad2l2
    • Mitotic
    • Gene
    • External
    • Function
    • Mad2l1
    • Protein
    • Search
    • Spindle
    • Location
    • Chromosome
    • Human
    • Bp
  • protein
    • Spindle
    • Component
    • End
    • External
    • Function
    • Mouse
    • Search
    • Location
    • Band
    • Chromosome
    • Human
    • Bp
  • interactions
    • Reading
    • References
    • Mad2b
    • Search
    • Location
    • Mitotic
    • Human
    • Mad2l2
  • mad2l1
    • Mad2l2

Connections between topic areas Semantic bridges

For MAD2L2, one of the stronger structural bridges in this analysis connects MAD2L2 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
MAD2L2 — Interactions · splits 4 ⟂ 6
MAD2L2 — Overview · splits 7 ⟂ 3

Map overview Semantic statistics

MAD2L2

Nodes10
Edges9
Triples105
Avg. degree1.8
Density0.2
Components1

Source & methodology

TTTA analyzes the structure around MAD2L2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — MAD2L2 · EN edition · Analysis: TopicsToTalkAbout

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