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SLC22A12: Inhibition, Clinical significance & Function

Solute carrier family 22 (organic anion/cation transporter), member 12, also known as SLC22A12 and URAT1, is a protein which in humans is encoded by the SLC22A12 gene.

Language: English [EN]
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SLC22A12 topic overview

The analysis highlights Inhibition, Clinical significance and Function as prominent areas in the source structure around SLC22A12.

Related topics
15
Source areas
5
Connected nodes
20
Extracted relationships
79
Related term clusters
9
Bridge connections
20

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Inhibition · 7 topics
Clinical significance · 3 topics
Function · 2 topics
Overview · 2 topics
Interactions · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SLC22A12, solute carrier family 22 (organic anion/urate transporter), member 12, OAT4L, RST, URAT1, solute carrier family 22 member 12
Band
11q13.1 · 19|19 A
Bgee
renal cortex · renal medulla · mammary gland · female breast · human kidney
BioGPS
n/a
Chr.
Chromosome 11 (human) · Chromosome 19 (mouse)
Databases
NCBI: entry; OMA: entry

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Interactions

Inhibition

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How SLC22A12 connects Entity context

The extracted context around SLC22A12 shows recurring relationship patterns in the source. For example, SLC22A12 → apical plasma membrane, brush border membrane, cellular homeostasis, extracellular exosome, inorganic anion exchanger activity, inorganic anion transport, integral component of membrane, integral component of plasma membrane, ion transport, membrane, organic acid transmembrane transport, organic anion transport, PDZ domain binding, plasma membrane, sodium-independent organic anion transmembrane transporter activity, sodium-independent organic anion transport, transmembrane transport, transmembrane transporter activity, transport, urate metabolic process Another extracted example is SLC22A12 → adipose tissue, distal tubule, female breast, human kidney, hypothalamus, lactiferous gland, liver, mammary gland, outer renal medulla, primary visual cortex, proximal convoluted tubule, proximal straight tubule, proximal tubule, renal cortex, renal medulla, right kidney, serous sac, subcutaneous adipose tissue. Use these groups to spot repeated connection types before inspecting the individual relationships.

SLC22A12

Top relations

Gene ontology · 22
SLC22A12 → apical plasma membrane, brush border membrane, cellular homeostasis, extracellular exosome, inorganic anion exchanger activity, inorganic anion transport, integral component of membrane, integral component of plasma membrane, ion transport, membrane, organic acid transmembrane transport, organic anion transport, PDZ domain binding, plasma membrane, sodium-independent organic anion transmembrane transporter activity, sodium-independent organic anion transport, transmembrane transport, transmembrane transporter activity, transport, urate metabolic process
Bgee · 18
SLC22A12 → adipose tissue, distal tubule, female breast, human kidney, hypothalamus, lactiferous gland, liver, mammary gland, outer renal medulla, primary visual cortex, proximal convoluted tubule, proximal straight tubule, proximal tubule, renal cortex, renal medulla, right kidney, serous sac, subcutaneous adipose tissue
RNA expression pattern · 18
SLC22A12 → adipose tissue, distal tubule, female breast, human kidney, hypothalamus, lactiferous gland, liver, mammary gland, outer renal medulla, primary visual cortex, proximal convoluted tubule, proximal straight tubule, proximal tubule, renal cortex, renal medulla, right kidney, serous sac, subcutaneous adipose tissue
Band · 2
SLC22A12 → 11q13.1, 19|19 A
Chr. · 2
SLC22A12 → Chromosome 11 (human), Chromosome 19 (mouse)
End · 2
SLC22A12 → 6,593,062 bp, 64,602,353 bp
Aliases · 1
SLC22A12 → SLC22A12, solute carrier family 22 (organic anion/urate transporter), member 12, OAT4L, RST, URAT1, solute carrier family 22 member 12
BioGPS · 1
SLC22A12 → n/a
Databases · 1
SLC22A12 → NCBI: entry; OMA: entry
Ensembl · 1
SLC22A12 → ENSG00000197891

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene bp chr human band transporter urate chromosome 11 protein organic anion also solute carrier family location mouse acid 22

SLC22A12 relationships Subject–Predicate–Object triples

TTTA extracted 79 structured relationships around SLC22A12. Examples in this analysis include SLC22A12 → Aliases → SLC22A12, solute carrier family 22 (organic anion/urate transporter), member 12, OAT4L, RST, URAT1, solute carrier family 22 member 12 and SLC22A12 → Band → 11q13.1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
SLC22A12AliasesSLC22A12, solute carrier family 22 (organic anion/urate transporter), member 12, OAT4L, RST, URAT1, solute carrier family 22 member 121.00infobox
SLC22A12Band11q13.11.00infobox
SLC22A12Band19|19 A1.00infobox
SLC22A12Bgeerenal cortex1.00infobox
SLC22A12Bgeerenal medulla1.00infobox
SLC22A12Bgeemammary gland1.00infobox
SLC22A12Bgeefemale breast1.00infobox
SLC22A12Bgeehuman kidney1.00infobox
SLC22A12Bgeelactiferous gland1.00infobox
SLC22A12Bgeeadipose tissue1.00infobox
SLC22A12Bgeeliver1.00infobox
SLC22A12Bgeesubcutaneous adipose tissue1.00infobox
SLC22A12Bgeeserous sac1.00infobox
SLC22A12Bgeeright kidney1.00infobox
SLC22A12Bgeeproximal tubule1.00infobox
SLC22A12Bgeeouter renal medulla1.00infobox
SLC22A12Bgeeproximal convoluted tubule1.00infobox
SLC22A12Bgeeproximal straight tubule1.00infobox
SLC22A12Bgeedistal tubule1.00infobox
SLC22A12Bgeeprimary visual cortex1.00infobox
SLC22A12Bgeehypothalamus1.00infobox
SLC22A12BioGPSn/a1.00infobox
SLC22A12Chr.Chromosome 11 (human)1.00infobox
SLC22A12Chr.Chromosome 19 (mouse)1.00infobox
SLC22A12DatabasesNCBI: entry; OMA: entry1.00infobox
SLC22A12End64,602,353 bp1.00infobox
SLC22A12End6,593,062 bp1.00infobox
SLC22A12EnsemblENSG000001978911.00infobox
SLC22A12Entrez1160851.00infobox
SLC22A12External IDsOMIM: 607096; MGI: 1195269; GeneCards: SLC22A121.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around SLC22A12 bring nearby vocabulary together. In this analysis, examples include Transporter, Encoded and Function. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • gene
    • Location
    • Organic
    • Chromosome
    • Human
    • Slc22a12
    • Transporter
    • Bp
    • Chr
    • End
    • Function
    • Member
    • Mouse
  • urate
    • Transporter
    • Function
    • Inhibition
    • Lesinurad
    • Anion
    • Location
    • Organic
    • Chromosome
    • Human
    • Slc22a12
    • Bp
    • Chr
  • integral membrane protein
    • Kidney
    • Membrane
    • Encoded
    • Integral
    • Protein
    • Slc22a12
    • Transporter
    • Exchanger
    • Mouse
    • Gene
    • Domain
    • End
  • function
    • Location
    • Organic
    • Chromosome
    • Exchanger
    • Human
    • Slc22a12
    • Transporter
    • Urate
    • Bp
    • Chr
    • Domain
    • End
  • SLC22A12
    • Transporter
    • Encoded
    • Function
    • Urat1
    • Gene
    • Location
    • Protein
    • Solute
    • Chromosome
    • Human
    • Urate
    • Bp
  • slc22a12
    • Transporter
    • Encoded
    • Function
    • Urat1
    • Gene
    • Location
    • Protein
    • Solute
    • Chromosome
    • Human
    • Urate
    • Bp
  • protein
    • Encoded
    • Integral
    • Kidney
    • Membrane
    • Slc22a12
    • Transporter
    • Exchanger
    • Gene
    • Domain
    • End
    • Function
    • Mouse
  • inhibition
    • Urate
    • Lesinurad
    • Member
    • Urat1
    • Location
    • Organic
    • Solute
    • Human
    • Slc22a12
    • Transporter

Connections between topic areas Semantic bridges

For SLC22A12, one of the stronger structural bridges in this analysis connects SLC22A12 with Inhibition. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
SLC22A12 — Inhibition · splits 13 ⟂ 8
SLC22A12 — Clinical significance · splits 17 ⟂ 4
SLC22A12 — Overview · splits 18 ⟂ 3
SLC22A12 — Function · splits 18 ⟂ 3

Map overview Semantic statistics

SLC22A12

Nodes21
Edges20
Triples79
Avg. degree1.9
Density0.095238
Components1

Source & methodology

TTTA analyzes the structure around SLC22A12 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Inhibition, Clinical significance & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — SLC22A12 · EN edition · Analysis: TopicsToTalkAbout

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