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Interferon type I

The type-I interferons (IFN) are cytokines which play essential roles in inflammation, immunoregulation, tumor cells recognition, and T-cell responses. In the human genome, a cluster of thirteen functional IFN genes is located at the 9p21.3 cytoband over approximately 400 kb including coding genes for IFNα (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7…

Applications, Sources and functions & Mammalian types

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Key facts & relationships

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AlphaFold
IPR000471 · PF00143
Available protein structures:
IPR000471 · PF00143
CATH
1au1
CDD
cd00095
InterPro
IPR000471
PDB
1b5l :24-187 1ovi :24-185 2hie :24-186 1itf :24-186 1au1B:22-187 2hif :24-182 1wu3I:22-182 IPR000471 PF00143 (ECOD; PDBsum)

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Overview

Sources and functions

Mammalian types

In cancer

Use in therapeutics

Interferonopathies

Non-mammalian types

Advanced semantic analysis

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Map overview Semantic statistics

Interferon type I

Nodes119
Edges118
Triples16
Avg. degree1.98
Density0.016807
Components1

How this topic connects Entity context

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Interferon type I

Top relations

AlphaFold · 2
Interferon type I → IPR000471, PF00143
Available protein structures: · 2
Interferon type I → IPR000471, PF00143
CATH · 1
Interferon type I → 1au1
CDD · 1
Interferon type I → cd00095
InterPro · 1
Interferon type I → IPR000471
PDB · 1
Interferon type I → 1b5l :24-187 1ovi :24-185 2hie :24-186 1itf :24-186 1au1B:22-187 2hif :24-182 1wu3I:22-182 IPR000471 PF00143 (ECOD; PDBsum)
Pfam · 1
Interferon type I → PF00143
PROSITE · 1
Interferon type I → PDOC00225
SCOP2 · 1
Interferon type I → 1au1 / SCOPe / SUPFAM
SMART · 1
Interferon type I → SM00076

Important terminology Word statistics

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Important terminology

type ifn ifn-α interferon genes ifns cancer types cluster multiple treatment cells cell found gene human also mammals species mammalian

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Interferon type IAlphaFoldIPR0004711.00infobox
Interferon type IAlphaFoldPF001431.00infobox
Interferon type IAvailable protein structures:IPR0004711.00infobox
Interferon type IAvailable protein structures:PF001431.00infobox
Interferon type ICATH1au11.00infobox
Interferon type ICDDcd000951.00infobox
Interferon type IInterProIPR0004711.00infobox
Interferon type IPDB1b5l :24-187 1ovi :24-185 2hie :24-186 1itf :24-186 1au1B:22-187 2hif :24-182 1wu3I:22-182 IPR000471 PF00143 (ECOD; PDBsum)1.00infobox
Interferon type IPfamPF001431.00infobox
Interferon type IPROSITEPDOC002251.00infobox
Interferon type ISCOP21au1 / SCOPe / SUPFAM1.00infobox
Interferon type ISMARTSM000761.00infobox
Interferon type ISymbolInterferons1.00infobox

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