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FANCM

Fanconi anemia, complementation group M, also known as FANCM, is a human gene. It is an emerging target in cancer therapy, in particular cancers with specific genetic deficiencies.

Art, Function & Clinical significance

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Function

10 related topics

Clinical significance

3 related topics

Overview

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Key facts & relationships

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3.6.4.13
Aliases
FANCM, FAAP250, KIAA1596, Fanconi anemia complementation group M, FA complementation group M, POF15, SPGF28
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4BXO, 4DAY, 4DRB, 4E45, 4M6W
Band
14q21.2 · 12 C1|12 27.21 cM
Bgee
sperm · oocyte · testicle · secondary oocyte · ventricular zone
BioGPS
n/a

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Overview

Function

Clinical significance

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Map overview Semantic statistics

FANCM

Nodes18
Edges17
Triples134
Avg. degree1.89
Density0.111111
Components1

How this topic connects Entity context

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FANCM

Top relations

Gene ontology · 21
FANCM → 3'-5' DNA helicase activity, ATP binding, cellular response to DNA damage stimulus, chromatin binding, DNA binding, DNA duplex unwinding, DNA repair, FANCM-MHF complex, Fanconi anaemia nuclear complex, helicase activity, hydrolase activity, interstrand cross-link repair, nuclease activity, nucleic acid phosphodiester bond hydrolysis, nucleoplasm, nucleotide binding, nucleus, positive regulation of protein monoubiquitination, protein binding, replication fork processing
related to As a drug target · 20
FANCM → ALT, ALT-associated, ALT-cells, Alternative Lengthening, An, As, Bloom Syndrome, DNA, Ectopic MM2, Expression, In, MM2, MM2-RMI1, PIP-199, RMI1, RMI2, Several, Telomeres, There, This
Bgee · 17
FANCM → Achilles tendon, blastocyst, epiblast, ganglionic eminence, genital tubercle, gonad, left testis, morula, oocyte, right testis, secondary oocyte, sperm, spermatocyte, tail of embryo, testicle, ventricular zone, zygote
RNA expression pattern · 17
FANCM → Achilles tendon, blastocyst, epiblast, ganglionic eminence, genital tubercle, gonad, left testis, morula, oocyte, right testis, secondary oocyte, sperm, spermatocyte, tail of embryo, testicle, ventricular zone, zygote
related to Meiosis · 14
FANCM → After, CO, D-loop, Deletion, DNA, DSB, During, Genetic, Homologous, In, NCO, Recombination, SDSA, The
related to Function · 10
FANCM → ATPase, C-terminus, DNA, FAAP24, Fanconi, It, MHF1, MHF2, R-loops, The
related to Disease association · 7
FANCM → Bi-allelic, ER-negative, Fanconi, Mono-allelic FANCM, Ovarian, Scandinavian, TNBC
related to External links · 3
FANCM → Medicine Medical Subject Headings, MeSH, National Library
Band · 2
FANCM → 12 C1|12 27.21 cM, 14q21.2
Chr. · 2
FANCM → Chromosome 12 (mouse), Chromosome 14 (human)

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Important terminology

dna human gene recombination bp protein chr band also activity fanconi chromosome co cancer 14 helicase nco meiosis complex anemia

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
FANCM3.6.4.131.00infobox
FANCMAliasesFANCM, FAAP250, KIAA1596, Fanconi anemia complementation group M, FA complementation group M, POF15, SPGF281.00infobox
FANCMAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4BXO, 4DAY, 4DRB, 4E45, 4M6W1.00infobox
FANCMBand14q21.21.00infobox
FANCMBand12 C1|12 27.21 cM1.00infobox
FANCMBgeesperm1.00infobox
FANCMBgeeoocyte1.00infobox
FANCMBgeetesticle1.00infobox
FANCMBgeesecondary oocyte1.00infobox
FANCMBgeeventricular zone1.00infobox
FANCMBgeegonad1.00infobox
FANCMBgeeright testis1.00infobox
FANCMBgeeleft testis1.00infobox
FANCMBgeeAchilles tendon1.00infobox
FANCMBgeeganglionic eminence1.00infobox
FANCMBgeetail of embryo1.00infobox
FANCMBgeeblastocyst1.00infobox
FANCMBgeegenital tubercle1.00infobox
FANCMBgeemorula1.00infobox
FANCMBgeezygote1.00infobox
FANCMBgeeepiblast1.00infobox
FANCMBgeespermatocyte1.00infobox
FANCMBioGPSn/a1.00infobox
FANCMChr.Chromosome 14 (human)1.00infobox
FANCMChr.Chromosome 12 (mouse)1.00infobox
FANCMDatabasesNCBI: entry; OMA: entry1.00infobox
FANCMEnd45,200,890 bp1.00infobox
FANCMEnd65,178,832 bp1.00infobox
FANCMEnsemblENSG000001877901.00infobox
FANCMEntrez576971.00infobox

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