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ATRX

Transcriptional regulator ATRX also known as ATP-dependent helicase ATRX, X-linked helicase II, or X-linked nuclear protein (XNP) is a protein that in humans is encoded by the ATRX gene.

Clinical significance, Function & Interactions

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Clinical significance

10 related topics

Function

7 related topics

Interactions

3 related topics

Overview

2 related topics

Key facts & relationships

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Aliases
ATRX, ATR2, JMS, MRXHF1, RAD54, RAD54L, SFM1, SHS, XH2, XNP, ZNF-HX, MRX52, alpha thalassemia/mental retardation syndrome X-linked, chromatin remodeler, ATRX chromatin remodeler
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2JM1, 2LBM, 2LD1, 3QL9, 3QLA, 3QLC, 3QLN, 4W5A
Band
Xq21.1 · X D|X 47.26 cM
Bgee
endothelial cell · Achilles tendon · epithelium of colon · cerebellar vermis · Brodmann area 23
BioGPS
n/a
Chr.
X chromosome (human) · X chromosome (mouse)

Topics to explore

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Overview

Function

Clinical significance

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

ATRX

Nodes27
Edges26
Triples149
Avg. degree1.93
Density0.074074
Components1

How this topic connects Entity context

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ATRX

Top relations

Gene ontology · 53
ATRX → ATP binding, cellular response to DNA damage stimulus, cellular response to hydroxyurea, chromatin binding, chromatin organization, chromatin remodeling, chromo shadow domain binding, chromosome, chromosome organization involved in meiotic cell cycle, DNA binding, DNA damage response, signal transduction by p53 class mediator, DNA duplex unwinding, DNA helicase activity, DNA methylation, DNA recombination, DNA repair, DNA translocase activity, DNA-binding transcription factor activity, RNA polymerase II-specific, forebrain development, helicase activity
Bgee · 20
ATRX → Achilles tendon, Brodmann area 23, cerebellar vermis, ciliary body, condyle, endothelial cell, Epithelium of choroid plexus, epithelium of colon, fossa, genital tubercle, Gonadal ridge, lobe of cerebellum, medullary collecting duct, pineal gland, pylorus, Region I of hippocampus proper, sural nerve, tail of embryo, tibia, vestibular sensory epithelium
RNA expression pattern · 20
ATRX → Achilles tendon, Brodmann area 23, cerebellar vermis, ciliary body, condyle, endothelial cell, Epithelium of choroid plexus, epithelium of colon, fossa, genital tubercle, Gonadal ridge, lobe of cerebellum, medullary collecting duct, pineal gland, pylorus, Region I of hippocampus proper, sural nerve, tail of embryo, tibia, vestibular sensory epithelium
related to External links · 11
ATRX → Alpha Thalassemia/Mental Retardation, Alpha-Thalassemia X-Linked Mental Retardation, ATRX Syndrome, GeneReviews/NCBI/NIH/UW, Human RAD54L, RAD54L, Syndrome, SyndromeHuman ATRX, UCSC Genome Browser, X-Linked, XLMR-Hypotonic Face SyndromeOMIM
related to Inherited mutations · 8
ATRX → ATR-X, DNA, Female, Inherited, Multiple, These, X-linked, XLMR
related to Function · 6
ATRX → ATPase, H3, In, SWI/SNF, These, Transcriptional
related to Somatic mutations · 5
ATRX → Acquired, ALT, Alternative Lengthening, Telomeres, There
related to Interactions · 3
ATRX → DAXX, EZH2, H3
Band · 2
ATRX → X D|X 47.26 cM, Xq21.1
Chr. · 2
ATRX → X chromosome (human), X chromosome (mouse)

Important terminology Word statistics

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Important terminology

gene human bp chromosome chr band location chromatin mutations x-linked helicase also nuclear protein mouse syndrome histone remodeling ucsc ii

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ATRXAliasesATRX, ATR2, JMS, MRXHF1, RAD54, RAD54L, SFM1, SHS, XH2, XNP, ZNF-HX, MRX52, alpha thalassemia/mental retardation syndrome X-linked, chromatin remodeler, ATRX chromatin remodeler1.00infobox
ATRXAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2JM1, 2LBM, 2LD1, 3QL9, 3QLA, 3QLC, 3QLN, 4W5A1.00infobox
ATRXBandXq21.11.00infobox
ATRXBandX D|X 47.26 cM1.00infobox
ATRXBgeeendothelial cell1.00infobox
ATRXBgeeAchilles tendon1.00infobox
ATRXBgeeepithelium of colon1.00infobox
ATRXBgeecerebellar vermis1.00infobox
ATRXBgeeBrodmann area 231.00infobox
ATRXBgeeEpithelium of choroid plexus1.00infobox
ATRXBgeepylorus1.00infobox
ATRXBgeetibia1.00infobox
ATRXBgeesural nerve1.00infobox
ATRXBgeeRegion I of hippocampus proper1.00infobox
ATRXBgeegenital tubercle1.00infobox
ATRXBgeetail of embryo1.00infobox
ATRXBgeepineal gland1.00infobox
ATRXBgeemedullary collecting duct1.00infobox
ATRXBgeevestibular sensory epithelium1.00infobox
ATRXBgeecondyle1.00infobox
ATRXBgeefossa1.00infobox
ATRXBgeelobe of cerebellum1.00infobox
ATRXBgeeGonadal ridge1.00infobox
ATRXBgeeciliary body1.00infobox
ATRXBioGPSn/a1.00infobox
ATRXChr.X chromosome (human)1.00infobox
ATRXChr.X chromosome (mouse)1.00infobox
ATRXDatabasesNCBI: entry; OMA: entry1.00infobox
ATRXEnd77,786,233 bp1.00infobox
ATRXEnd104,973,009 bp1.00infobox

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