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Growth differentiation factor 2 (GDF2) also known as bone morphogenetic protein (BMP)-9 is a protein that in humans is encoded by the GDF2 gene. GDF2 belongs to the transforming growth factor beta superfamily.
The analysis highlights Function, Signaling and Interactions as prominent areas in the source structure around GDF2.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
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The extracted context around GDF2 shows recurring relationship patterns in the source. For example, GDF2 → activin receptor signaling pathway, angiogenesis, blood vessel morphogenesis, BMP signaling pathway, branching involved in blood vessel morphogenesis, cartilage development, cell development, cellular iron ion homeostasis, cellular response to BMP stimulus, cytokine activity, extracellular exosome, extracellular region, extracellular space, growth factor activity, negative regulation of angiogenesis, negative regulation of blood vessel endothelial cell migration, negative regulation of cell growth, negative regulation of DNA biosynthetic process, negative regulation of DNA replication, negative regulation of endothelial cell migration Another extracted example is GDF2 → abdominal wall, atrioventricular junction, atrium, autopod region, calvaria, embryo, fetal liver hematopoietic progenitor cell, haematopoietic system, hepatobiliary system, hypothalamus, left lobe of liver, left ventricle, liver, mesenteric lymph nodes, placenta, right atrium, right auricle of heart, right lobe of liver, testicle, ventricle of the heart. Use these groups to spot repeated connection types before inspecting the individual relationships.
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factor differentiation growth bp human type gene chr band also receptor pathway ii alk1 signaling cells chromosome 10 bmps affinity
TTTA extracted 153 structured relationships around GDF2. Examples in this analysis include GDF2 → Aliases → GDF2, BMP-9, BMP9, HHT5, growth differentiation factor 2 and GDF2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ZKZ, 4FAO, 4MPL, 4YCG, 4YCI. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| GDF2 | Aliases | GDF2, BMP-9, BMP9, HHT5, growth differentiation factor 2 | 1.00 | infobox |
| GDF2 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ZKZ, 4FAO, 4MPL, 4YCG, 4YCI | 1.00 | infobox |
| GDF2 | Band | 10q11.22 | 1.00 | infobox |
| GDF2 | Band | 14|14 B | 1.00 | infobox |
| GDF2 | Bgee | testicle | 1.00 | infobox |
| GDF2 | Bgee | right lobe of liver | 1.00 | infobox |
| GDF2 | Bgee | placenta | 1.00 | infobox |
| GDF2 | Bgee | atrium | 1.00 | infobox |
| GDF2 | Bgee | right atrium | 1.00 | infobox |
| GDF2 | Bgee | right auricle of heart | 1.00 | infobox |
| GDF2 | Bgee | haematopoietic system | 1.00 | infobox |
| GDF2 | Bgee | hypothalamus | 1.00 | infobox |
| GDF2 | Bgee | ventricle of the heart | 1.00 | infobox |
| GDF2 | Bgee | left ventricle | 1.00 | infobox |
| GDF2 | Bgee | hepatobiliary system | 1.00 | infobox |
| GDF2 | Bgee | liver | 1.00 | infobox |
| GDF2 | Bgee | fetal liver hematopoietic progenitor cell | 1.00 | infobox |
| GDF2 | Bgee | embryo | 1.00 | infobox |
| GDF2 | Bgee | left lobe of liver | 1.00 | infobox |
| GDF2 | Bgee | autopod region | 1.00 | infobox |
| GDF2 | Bgee | atrioventricular junction | 1.00 | infobox |
| GDF2 | Bgee | mesenteric lymph nodes | 1.00 | infobox |
| GDF2 | Bgee | abdominal wall | 1.00 | infobox |
| GDF2 | Bgee | calvaria | 1.00 | infobox |
| GDF2 | BioGPS | n/a | 1.00 | infobox |
| GDF2 | Chr. | Chromosome 10 (human) | 1.00 | infobox |
| GDF2 | Chr. | Chromosome 14 (mouse) | 1.00 | infobox |
| GDF2 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| GDF2 | End | 47,327,588 bp | 1.00 | infobox |
| GDF2 | End | 33,669,155 bp | 1.00 | infobox |
The concept neighborhoods around GDF2 bring nearby vocabulary together. In this analysis, examples include Also, Type and Growth. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For GDF2, one of the stronger structural bridges in this analysis connects GDF2 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around GDF2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Signaling & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — GDF2 · EN edition · Analysis: TopicsToTalkAbout
