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USP9X: Clinical significance, Function & Interactions

Probable ubiquitin carboxyl-terminal hydrolase FAF-X is an enzyme that in humans is encoded by the USP9X gene.

Language: English [EN]
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USP9X topic overview

The analysis highlights Clinical significance, Function and Interactions as prominent areas in the source structure around USP9X.

Related topics
44
Source areas
5
Connected nodes
49
Extracted relationships
121
Concept neighborhoods
11
Bridge connections
49

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 24 topics
Function · 8 topics
Interactions · 7 topics
Gene · 3 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.4.19.12
Aliases
USP9X, DFFRX, FAF, FAM, MRX99, MRXS99F, ubiquitin specific peptidase 9, X-linked, ubiquitin specific peptidase 9 X-linked, XLID99
Band
Xp11.4 · X A1.1|X 7.95 cM
Bgee
middle frontal gyrus · secondary oocyte · paraflocculus of cerebellum · Skeletal muscle tissue of rectus abdominis · jejunum
BioGPS
More reference expression data
Chr.
X chromosome (human) · X chromosome (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Gene

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How USP9X connects Entity context

The extracted context around USP9X shows recurring relationship patterns in the source. For example, USP9X → axon extension, BMP signaling pathway, cell cycle, cell division, cell projection, chromosome segregation, co-SMAD binding, cysteine-type endopeptidase activity, cysteine-type peptidase activity, cytoplasm, cytosol, deubiquitinase activity, female gamete generation, growth cone, hydrolase activity, Lys48-specific deubiquitinase activity, membrane, negative regulation of transcription by RNA polymerase II, neuron migration, peptidase activity Another extracted example is USP9X → dentate gyrus of hippocampal formation granule cell, frontal pole, genital tubercle, jejunal mucosa, jejunum, lateral nuclear group of thalamus, middle frontal gyrus, paraflocculus of cerebellum, pars reticulata, pineal gland, primary visual cortex, secondary oocyte, Skeletal muscle tissue of rectus abdominis, substantia nigra, tail of embryo, trabecular bone, triceps brachii muscle, ventricular zone, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

USP9X

Top relations

Gene ontology · 34
USP9X → axon extension, BMP signaling pathway, cell cycle, cell division, cell projection, chromosome segregation, co-SMAD binding, cysteine-type endopeptidase activity, cysteine-type peptidase activity, cytoplasm, cytosol, deubiquitinase activity, female gamete generation, growth cone, hydrolase activity, Lys48-specific deubiquitinase activity, membrane, negative regulation of transcription by RNA polymerase II, neuron migration, peptidase activity
Bgee · 19
USP9X → dentate gyrus of hippocampal formation granule cell, frontal pole, genital tubercle, jejunal mucosa, jejunum, lateral nuclear group of thalamus, middle frontal gyrus, paraflocculus of cerebellum, pars reticulata, pineal gland, primary visual cortex, secondary oocyte, Skeletal muscle tissue of rectus abdominis, substantia nigra, tail of embryo, trabecular bone, triceps brachii muscle, ventricular zone, zygote
RNA expression pattern · 19
USP9X → dentate gyrus of hippocampal formation granule cell, frontal pole, genital tubercle, jejunal mucosa, jejunum, lateral nuclear group of thalamus, middle frontal gyrus, paraflocculus of cerebellum, pars reticulata, pineal gland, primary visual cortex, secondary oocyte, Skeletal muscle tissue of rectus abdominis, substantia nigra, tail of embryo, trabecular bone, triceps brachii muscle, ventricular zone, zygote
related to USP9X syndrome · 10
USP9X → As, Being, Females, In, Less, Other, Symptoms, This, Variants, X-inactivation
related to Function · 8
USP9X → Depletion, EGF, High, In, It, Notch, USP9X-knockout, Wnt
related to Clinical significance · 7
USP9X → Alzheimer's, Huntington's, Neurodegenerative, Parkinson's, Specifically, Three, X-linked
Band · 2
USP9X → X A1.1|X 7.95 cM, Xp11.4
Chr. · 2
USP9X → X chromosome (human), X chromosome (mouse)
End · 2
USP9X → 13,039,567 bp, 41,236,579 bp
3.4.19.12 · 1
USP9X → ↗

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene chromosome bp human females chr band males syndrome mouse include function symptoms enzyme protein location peptidase variants ubiquitin expression

USP9X relationships Subject–Predicate–Object triples

TTTA extracted 121 structured relationships around USP9X. Examples in this analysis include USP9X → 3.4.19.12 → ↗ and USP9X → Aliases → USP9X, DFFRX, FAF, FAM, MRX99, MRXS99F, ubiquitin specific peptidase 9, X-linked, ubiquitin specific peptidase 9 X-linked, XLID99. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
USP9X3.4.19.121.00infobox
USP9XAliasesUSP9X, DFFRX, FAF, FAM, MRX99, MRXS99F, ubiquitin specific peptidase 9, X-linked, ubiquitin specific peptidase 9 X-linked, XLID991.00infobox
USP9XBandXp11.41.00infobox
USP9XBandX A1.1|X 7.95 cM1.00infobox
USP9XBgeemiddle frontal gyrus1.00infobox
USP9XBgeesecondary oocyte1.00infobox
USP9XBgeeparaflocculus of cerebellum1.00infobox
USP9XBgeeSkeletal muscle tissue of rectus abdominis1.00infobox
USP9XBgeejejunum1.00infobox
USP9XBgeepars reticulata1.00infobox
USP9XBgeejejunal mucosa1.00infobox
USP9XBgeetrabecular bone1.00infobox
USP9XBgeefrontal pole1.00infobox
USP9XBgeelateral nuclear group of thalamus1.00infobox
USP9XBgeegenital tubercle1.00infobox
USP9XBgeezygote1.00infobox
USP9XBgeesubstantia nigra1.00infobox
USP9XBgeetail of embryo1.00infobox
USP9XBgeedentate gyrus of hippocampal formation granule cell1.00infobox
USP9XBgeepineal gland1.00infobox
USP9XBgeeventricular zone1.00infobox
USP9XBgeetriceps brachii muscle1.00infobox
USP9XBgeeprimary visual cortex1.00infobox
USP9XBioGPSMore reference expression data1.00infobox
USP9XChr.X chromosome (human)1.00infobox
USP9XChr.X chromosome (mouse)1.00infobox
USP9XDatabasesNCBI: entry; OMA: entry1.00infobox
USP9XEnd41,236,579 bp1.00infobox
USP9XEnd13,039,567 bp1.00infobox
USP9XEnsemblENSG000001244861.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around USP9X bring nearby vocabulary together. In this analysis, examples include Variants, Males and Females. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • gene
    • Usp9x
    • Chromosome
    • Function
    • Variants
    • Males
    • Females
    • Location
    • One
    • Bp
    • Chr
    • Human
    • Syndrome
  • function
    • Activity
    • Peptidase
    • Location
    • Loss
    • Gene
    • Bp
    • Chr
    • Human
    • Chromosome
    • A1
    • End
    • Hydrolase
  • enzyme
    • Ubiquitin
    • Activity
    • Humans
    • Hydrolase
    • Peptidase
    • Location
    • Protein
    • Function
    • Usp9x
    • Gene
    • Bp
    • Chr
  • syndrome
    • Females
    • Found
    • Variants
    • Usp9x
    • Males
    • Peptidase
    • Ubiquitin
    • Compared
    • Location
    • Mutations
    • One
    • Human
  • peptidase
    • Location
    • Human
    • A1
    • End
    • Ubiquitin
    • Cell
    • Expression
    • Protein
    • Band
    • Mouse
    • Syndrome
    • Usp9x
  • ubiquitin
    • Activity
    • Peptidase
    • Location
    • Function
    • Bp
    • Chr
    • Gene
    • Human
    • Syndrome
    • Chromosome
    • Usp9x
  • x-linked intellectual disability
    • Disability
    • Intellectual
    • Dysmorphia
    • Symptoms
    • Include
    • Mutations
    • Males
    • Females
  • intellectual disability
    • Disability
    • Intellectual
    • Dysmorphia
    • Symptoms
    • Include
    • Mutations
    • Males
    • Females

Connections between topic areas Semantic bridges

For USP9X, one of the stronger structural bridges in this analysis connects USP9X with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
USP9XClinical significance · splits 25 ⟂ 25
USP9XFunction · splits 41 ⟂ 9
USP9XInteractions · splits 42 ⟂ 8
USP9XGene · splits 46 ⟂ 4
USP9XOverview · splits 47 ⟂ 3

Map overview Semantic statistics

USP9X

Nodes50
Edges49
Triples121
Avg. degree1.96
Density0.04
Components1

Source & methodology

TTTA analyzes the structure around USP9X to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Function & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — USP9X · EN edition · Analysis: TopicsToTalkAbout

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