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Active site

In biology and biochemistry, the active site is the region of an enzyme where substrate molecules bind and undergo a chemical reaction. The active site consists of amino acid residues that form temporary bonds with the substrate, the binding site, and residues that catalyse a reaction of that substrate, the catalytic site. Although the active site…

Regions, Binding site & Mechanisms involved in Catalytic process

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Binding site

MutatedHydrogen bondsVan der Waals interactionsHydrophobic interactionsElectrostatic force
26 related topics

Mechanisms involved in Catalytic process

Effective concentrationDesolvation energyEntropyMolecular orbitalIon
30 related topics

Examples of enzyme catalysis mechanisms

Glutathione reductaseGlutathioneThiolOxidisedDisulphide bond
25 related topics

Examples of competitive and irreversible enzyme inhibitors

HIV protease inhibitorsAIDSDNA replicationHIV proteaseProline
23 related topics

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Overview

Binding site

Types of non-covalent interactions

Catalytic site

Mechanisms involved in Catalytic process

Examples of enzyme catalysis mechanisms

Unbinding

Cofactors

Inhibitors

Examples of competitive and irreversible enzyme inhibitors

In drug discovery

Allosteric sites

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Map overview Semantic statistics

Active site

Nodes155
Edges154
Triples164
Avg. degree1.99
Density0.012903
Components1

How this topic connects Entity context

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Active site

Top relations

related to Cofactors · 18
Active site → ATP, But, Coenzyme, Coenzymes, Enzymes, Flavin, For, If, In, It, Mostly, NAD, NADH, On, One, Only, Otherwise, This
related to Glutathione reductase · 16
Active site → Arg-218, Arg-224, During, FAD, FADH, Glutathione, GR, GSH, GSSG, His-219, In, It, NADP, NADPH, The, The NADPH
related to In drug discovery · 13
Active site → Active, AIDS, An, Comparison, CPASS, Identification, If, Modern, Protein Active Site Structures, Proteolytic, The, These, This
related to Chymotrypsin · 12
Active site → Asp-102, Chymotrypsin, First, Furthermore, Gly-193, His-57, In, It, L-isomers, RCOO, Ser-195, The
related to Acid/base catalysis · 10
Active site → Brønsted, But, Candidate, If, In, Lowry, Since, The, These, This
related to Binding site · 10
Active site → An, ES, For, Initially, NAD, Otherwise, The, There, Usually, Waals
related to Lock and key hypothesis · 10
Active site → Apart, As, Emil Fischer, For, He, However, If, Key, The Lock, This
related to Approximation of the reactant · 9
Active site → But, During, Firstly, In, Molecular, Next, Since, The, This
related to Irreversible inhibitor: Diisopropyl fluorophosphate · 8
Active site → DIFP, Diisopropyl, HF, It, P-F, The OH, Then, When
related to Types of non-covalent interactions · 8
Active site → COO, Electrostatic, For, Hydrogen, In, R-COOH, RCOO, The

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Important terminology

active site substrate enzyme reaction one substrates catalysis form bind bond enzymes acid amino inhibitors binding fit protein usually interaction

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Active siteis aregion of an enzyme where substrate molecules bind and undergo a chemical reaction0.90text
Active sitelocated inthe linkage between two subunits0.90text
temperature likely influences the pathway taken during bindinginstance ofFactors0.80text
with higher temperatures predicted to increase the importance of conformational selectioninstance ofFactors0.80text
decrease that of induced fit.Lockinstance ofFactors0.80text
key hypothesisThis concept was suggested by the 19th-century chemist Emil Fischerinstance ofFactors0.80text
protonated guanidine side chain of arginineinstance ofwill attract positively charged groups0.80text
polarizabilityinstance ofBoth groups are also affected by their chemical properties0.80text
electronegativityinstance ofBoth groups are also affected by their chemical properties0.80text
ionization potentialinstance ofBoth groups are also affected by their chemical properties0.80text
hydrogen bond or hydrophobic interactioninstance ofMostly they are connected to the active site by non-covalent bonds0.80text
enzyme inhibitorsinstance ofits inhibitor can be used to specifically wipe them out.Active sites can be mapped to aid the design of new drugs0.80text

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    Min side: 3
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