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FMR1: Products, Function & Gene expression

FMR1 (Fragile X Messenger Ribonucleoprotein 1) is a human gene that codes for a protein called fragile X messenger ribonucleoprotein, or FMRP. This protein, most commonly found in the brain, is essential for normal cognitive development and female reproductive function. Mutations of this gene can lead to fragile X syndrome, intellectual disability, FXPOI…

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FMR1 topic overview

The analysis highlights Products, Function and Gene expression as prominent areas in the source structure around FMR1.

Related topics
60
Source areas
5
Connected nodes
65
Extracted relationships
225
Concept neighborhoods
25
Bridge connections
65

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 23 topics
Gene expression · 12 topics
Overview · 11 topics
Related conditions · 8 topics
Interactions · 6 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
FMR1, FMRP, FRAXA, POF, POF1, fragile X mental retardation 1, FMRP translational regulator 1, fragile X messenger ribonucleoprotein 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2BKD, 2FMR, 2LA5, 2QND, 4OVA, 4QVZ, 4QW2, 5DE5, 5DE8, 5DEA
Band
Xq27.3 · X A7.1|X 34.83 cM
Bgee
caput epididymis · corpus epididymis · sural nerve · endothelial cell · Epithelium of choroid plexus
BioGPS
More reference expression data
Chr.
X chromosome (human) · X chromosome (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Gene expression

Related conditions

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How FMR1 connects Entity context

The extracted context around FMR1 shows recurring relationship patterns in the source. For example, FMR1 → anterograde axonal transport, axon, axon cytoplasm, axon terminus, Cajal body, cell junction, cell projection, cellular response to DNA damage stimulus, cellular response to hydroxyurea, cellular response to UV, cellular response to virus, central nervous system development, chromatin binding, chromocenter, chromosome, chromosome, centromeric region, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic stress granule, cytosol Another extracted example is FMR1 → abdominal wall, Achilles tendon, caput epididymis, corpus epididymis, cumulus cell, endothelial cell, Epithelium of choroid plexus, epithelium of colon, Gonadal ridge, left lung lobe, mandibular prominence, migratory enteric neural crest cell, mucosa of paranasal sinus, pineal gland, retinal pigment epithelium, sural nerve, tail of epididymis, vas deferens, ventricular zone, white adipose tissue. Use these groups to spot repeated connection types before inspecting the individual relationships.

FMR1

Top relations

Gene ontology · 115
FMR1 → anterograde axonal transport, axon, axon cytoplasm, axon terminus, Cajal body, cell junction, cell projection, cellular response to DNA damage stimulus, cellular response to hydroxyurea, cellular response to UV, cellular response to virus, central nervous system development, chromatin binding, chromocenter, chromosome, chromosome, centromeric region, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic stress granule, cytosol
Bgee · 20
FMR1 → abdominal wall, Achilles tendon, caput epididymis, corpus epididymis, cumulus cell, endothelial cell, Epithelium of choroid plexus, epithelium of colon, Gonadal ridge, left lung lobe, mandibular prominence, migratory enteric neural crest cell, mucosa of paranasal sinus, pineal gland, retinal pigment epithelium, sural nerve, tail of epididymis, vas deferens, ventricular zone, white adipose tissue
RNA expression pattern · 20
FMR1 → abdominal wall, Achilles tendon, caput epididymis, corpus epididymis, cumulus cell, endothelial cell, Epithelium of choroid plexus, epithelium of colon, Gonadal ridge, left lung lobe, mandibular prominence, migratory enteric neural crest cell, mucosa of paranasal sinus, pineal gland, retinal pigment epithelium, sural nerve, tail of epididymis, vas deferens, ventricular zone, white adipose tissue
related to Gene expression · 14
FMR1 → American College, CGG, DNA, FMRP, Genomics, Higher, If, In, Medical Genetics, SMRT, The, The FMR1, This, Trinucleotide
related to Synaptic plasticity · 13
FMR1 → FMRP, FMRP-dependent, Fragile, Furthermore, Group, It, Messenger Ribonucleoprotein, Post-synaptic, Specifically, Studies, Synaptic, The, This
related to Fragile X syndrome · 8
FMR1 → Almost, As, CGG, Fewer, FMRP, In, These, Without
related to Interactions · 4
FMR1 → CYFIP1, CYFIP2, FXR1, NUFIP1
related to Polycystic ovarian syndrome · 3
FMR1 → PCOS, PCOS-like, The
related to Premature ovarian aging · 3
FMR1 → CGG, Minor, The FMR1
Band · 2
FMR1 → X A7.1|X 34.83 cM, Xq27.3

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

fmrp gene protein fragile translation syndrome synaptic human mrna chromosome function mglur bp role synthesis messenger plasticity ovarian chr band

FMR1 relationships Subject–Predicate–Object triples

TTTA extracted 225 structured relationships around FMR1. Examples in this analysis include FMR1 → Aliases → FMR1, FMRP, FRAXA, POF, POF1, fragile X mental retardation 1, FMRP translational regulator 1, fragile X messenger ribonucleoprotein 1 and FMR1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2BKD, 2FMR, 2LA5, 2QND, 4OVA, 4QVZ, 4QW2, 5DE5, 5DE8, 5DEA. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
FMR1AliasesFMR1, FMRP, FRAXA, POF, POF1, fragile X mental retardation 1, FMRP translational regulator 1, fragile X messenger ribonucleoprotein 11.00infobox
FMR1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2BKD, 2FMR, 2LA5, 2QND, 4OVA, 4QVZ, 4QW2, 5DE5, 5DE8, 5DEA1.00infobox
FMR1BandXq27.31.00infobox
FMR1BandX A7.1|X 34.83 cM1.00infobox
FMR1Bgeecaput epididymis1.00infobox
FMR1Bgeecorpus epididymis1.00infobox
FMR1Bgeesural nerve1.00infobox
FMR1Bgeeendothelial cell1.00infobox
FMR1BgeeEpithelium of choroid plexus1.00infobox
FMR1Bgeetail of epididymis1.00infobox
FMR1Bgeemucosa of paranasal sinus1.00infobox
FMR1Bgeeepithelium of colon1.00infobox
FMR1Bgeeretinal pigment epithelium1.00infobox
FMR1BgeeAchilles tendon1.00infobox
FMR1BgeeGonadal ridge1.00infobox
FMR1Bgeecumulus cell1.00infobox
FMR1Bgeewhite adipose tissue1.00infobox
FMR1Bgeevas deferens1.00infobox
FMR1Bgeeabdominal wall1.00infobox
FMR1Bgeemigratory enteric neural crest cell1.00infobox
FMR1Bgeeleft lung lobe1.00infobox
FMR1Bgeepineal gland1.00infobox
FMR1Bgeeventricular zone1.00infobox
FMR1Bgeemandibular prominence1.00infobox
FMR1BioGPSMore reference expression data1.00infobox
FMR1Chr.X chromosome (human)1.00infobox
FMR1Chr.X chromosome (mouse)1.00infobox
FMR1DatabasesNCBI: entry; OMA: entry1.00infobox
FMR1End147,951,125 bp1.00infobox
FMR1End67,761,569 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around FMR1 bring nearby vocabulary together. In this analysis, examples include Gene, Chromosome and Syndrome. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • FMR1
    • Gene
    • Chromosome
    • Syndrome
    • Fragile
    • Premutation
    • Human
    • Ribonucleoprotein
    • Messenger
    • Ovarian
    • Cgg
    • Function
    • Called
  • fmr1
    • Gene
    • Chromosome
    • Syndrome
    • Fragile
    • Premutation
    • Human
    • Ribonucleoprotein
    • Messenger
    • Ovarian
    • Cgg
    • Function
    • Called
  • gene
    • Chromosome
    • Human
    • Ovarian
    • Function
    • Bp
    • Chr
    • Ribonucleoprotein
    • Syndrome
    • Messenger
    • Cgg
    • Ataxia
    • Band
  • protein
    • Synthesis
    • Mrna
    • May
    • Shown
    • Translational
    • Synaptic
    • Translation
    • Dna
    • Ribonucleoprotein
    • Response
    • Stimulation
    • Function
  • fragile x syndrome
    • Syndrome
    • Ribonucleoprotein
    • Messenger
    • Tremor
    • Gene
    • Associated
    • Ataxia
    • Fmrp
    • Ovarian
    • Chromosome
    • Translational
    • Cgg
  • fragile x-associated primary ovarian insufficiency
    • Syndrome
    • Ribonucleoprotein
    • Messenger
    • Tremor
    • Associated
    • Gene
    • Ataxia
    • Fmrp
    • Ovarian
    • Role
    • Human
    • Chromosome
  • fragile x-associated tremor/ataxia syndrome
    • Ataxia
    • Tremor
    • Syndrome
    • Ribonucleoprotein
    • Messenger
    • Ovarian
    • Gene
    • Associated
    • Fragile
    • Fmrp
    • Cognitive
    • Regulator
  • protein synthesis
    • Synthesis
    • Mrna
    • May
    • Shown
    • Translational
    • Synaptic
    • Translation
    • Dna
    • Ribonucleoprotein
    • Response
    • Stimulation
    • Function

Connections between topic areas Semantic bridges

For FMR1, one of the stronger structural bridges in this analysis connects FMR1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
FMR1Function · splits 42 ⟂ 24
FMR1Gene expression · splits 53 ⟂ 13
FMR1Overview · splits 54 ⟂ 12
FMR1Related conditions · splits 57 ⟂ 9
FMR1Interactions · splits 59 ⟂ 7

Map overview Semantic statistics

FMR1

Nodes66
Edges65
Triples225
Avg. degree1.97
Density0.030303
Components1

Source & methodology

TTTA analyzes the structure around FMR1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Products, Function & Gene expression, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — FMR1 · EN edition · Analysis: TopicsToTalkAbout

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