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Metronidazole

Metronidazole, sold under the brand name Flagyl and Metrogyl among others, is an antibiotic and antiprotozoal medication. It is used either alone or with other antibiotics to treat pelvic inflammatory disease, endocarditis, and bacterial vaginosis. It is effective for dracunculiasis, giardiasis, trichomoniasis, and amebiasis. It is an option for a first…

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Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
A01AB17 (WHO) D06BX01 (WHO), G01AF01 (WHO), J01XD01 (WHO), P01AB01 (WHO), QP51CA01 (WHO)
Bioavailability
80% (by mouth), 60–80% (rectal), 20–25% (vaginal)
CAS Number
443-48-1 Y
ChEBI
CHEBI:6909 Y

Topics to explore

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Overview

Medical uses

Adverse effects

Drug interactions

Pregnancy and breastfeeding

Pharmacology

History

Synthesis

Research

Veterinary use

Advanced semantic analysis

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Map overview Semantic statistics

Metronidazole

Nodes158
Edges157
Triples150
Avg. degree1.99
Density0.012658
Components1

How this topic connects Entity context

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Metronidazole

Top relations

related to Research · 14
Metronidazole → By, Cell, Chemokines, Cytokines, Despite, IL-1β, IL-6, In, Increased ROS, Metronidazole's, NF-κB, ROS, Studies, TNF-alpha
related to Mutagenesis and carcinogenesis · 13
Metronidazole → Although, Cancer, Crohn's, IARC, In, International Agency, National Toxicology Program, NTP, One, Research, The, WHO, World Health Organization
related to Veterinary use · 8
Metronidazole → Another, Drug Administration, FDA, Food, Giardia, In, It, The
related to Mechanism of action · 7
Metronidazole → After, DNA, Elevation, It, PFOR, Therefore, This
related to Medical uses · 7
Metronidazole → Bacteroides, Clostridium, Fusobacterium, Helicobacter, It, Peptostreptococcus, Prevotella
has effect · 6
Metronidazole → Common, High, In, Infrequent, Intravenous, Some
related to Pharmacokinetics · 6
Metronidazole → About, Food, It, Of, Oral, The
related to Resistance · 6
Metronidazole → Bacteriodes, Currently, In, Resistance, Strains, The
related to C. difficile colitis · 5
Metronidazole → Clostridioides, IDSA, In, Initial, Vancomycin
Legal status · 4
Metronidazole → AU: S4 (Prescription only), CA: ℞-only, UK: POM (Prescription only), US: ℞-only

Important terminology Word statistics

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Important terminology

treatment may effects also used associated drug bacterial pregnancy name include use flagyl therapy studies inflammatory disease first intravenous resistance

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Metronidazole3D model (JSmol)Interactive image1.00infobox
MetronidazoleAHFS/Drugs.comMonograph1.00infobox
MetronidazoleATC codeA01AB17 (WHO) D06BX01 (WHO), G01AF01 (WHO), J01XD01 (WHO), P01AB01 (WHO), QP51CA01 (WHO)1.00infobox
MetronidazoleBioavailability80% (by mouth), 60–80% (rectal), 20–25% (vaginal)1.00infobox
MetronidazoleCAS Number443-48-1 Y1.00infobox
MetronidazoleChEBICHEBI:6909 Y1.00infobox
MetronidazoleChEMBLChEMBL137 Y1.00infobox
MetronidazoleChemSpider4029 Y1.00infobox
MetronidazoleCompTox Dashboard (EPA)DTXSID20208921.00infobox
MetronidazoleDrugBankDB00916 Y1.00infobox
MetronidazoleECHA InfoCard100.006.4891.00infobox
MetronidazoleElimination half-life8 hours1.00infobox
MetronidazoleExcretionUrine (77%), faeces (14%)1.00infobox
MetronidazoleFormulaC6H9N3O31.00infobox
MetronidazoleKEGGD00409 Y1.00infobox
MetronidazoleLegal statusAU: S4 (Prescription only)1.00infobox
MetronidazoleLegal statusCA: ℞-only1.00infobox
MetronidazoleLegal statusUK: POM (Prescription only)1.00infobox
MetronidazoleLegal statusUS: ℞-only1.00infobox
MetronidazoleLicense dataUS DailyMed: Metronidazole1.00infobox
MetronidazoleMedlinePlusa6890111.00infobox
MetronidazoleMelting point159 to 163 °C (318 to 325 °F)1.00infobox
MetronidazoleMetabolismLiver1.00infobox
MetronidazoleMetabolitesHydroxymetronidazole1.00infobox
MetronidazoleMolar mass171.156 g·mol−11.00infobox
MetronidazoleNIAID ChemDB0079531.00infobox
MetronidazolePDB ligand2MN (PDBe, RCSB PDB)1.00infobox
MetronidazolePregnancy categoryAU: B21.00infobox
MetronidazoleProtein binding20%1.00infobox
MetronidazolePubChem CID41731.00infobox

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