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Lomitapide

Lomitapide, sold under the brand name Juxtapid in the US and Lojuxta in the EU, is a medication used as a lipid-lowering agent for the treatment of familial hypercholesterolemia, developed by Aegerion Pharmaceuticals. It has been tested in clinical trials as single treatment and in combinations with atorvastatin, ezetimibe and fenofibrate.

Overview, Mechanism of action & Side effects

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Key facts & relationships

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3D model (JSmol)
Interactive image
ATC code
C10AX12 (WHO)
CAS Number
182431-12-5 Y · mesylate: 202914-84-9
ChEBI
CHEBI:72297 N · mesylate: CHEBI:72299
ChEMBL
ChEMBL354541 · mesylate: ChEMBL2105662
ChemSpider
8028764 N · mesylate: 9449335

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Overview

Mechanism of action

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Map overview Semantic statistics

Lomitapide

Nodes20
Edges19
Triples44
Avg. degree1.9
Density0.1
Components1

How this topic connects Entity context

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Lomitapide

Top relations

related to Mechanism of action · 7
Lomitapide → Aegerion, FDA, HoFH, In December, MTP, MTTP, VLDL
related to External links · 5
Lomitapide → Archived, Drug Information Portal, January, Medicine, National Library
License data · 3
Lomitapide → EU EMA: by INN, US DailyMed: Lomitapide, US FDA: Lomitapide
CAS Number · 2
Lomitapide → 182431-12-5 Y, mesylate: 202914-84-9
ChEBI · 2
Lomitapide → CHEBI:72297 N, mesylate: CHEBI:72299
ChEMBL · 2
Lomitapide → ChEMBL354541, mesylate: ChEMBL2105662
ChemSpider · 2
Lomitapide → 8028764 N, mesylate: 9449335
DrugBank · 2
Lomitapide → DB08827 Y, mesylate: DBSALT000110
KEGG · 2
Lomitapide → D09637 Y, mesylate: D09638
Legal status · 2
Lomitapide → EU: Rx-only, US: ℞-only

Important terminology Word statistics

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Important terminology

us lipid-lowering familial hypercholesterolemia approved lipoprotein hofh fda drug treatment ldl name juxtapid lojuxta eu administration aegerion december 2012 homozygous

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Lomitapide3D model (JSmol)Interactive image1.00infobox
LomitapideATC codeC10AX12 (WHO)1.00infobox
LomitapideCAS Number182431-12-5 Y1.00infobox
LomitapideCAS Numbermesylate: 202914-84-91.00infobox
LomitapideChEBICHEBI:72297 N1.00infobox
LomitapideChEBImesylate: CHEBI:722991.00infobox
LomitapideChEMBLChEMBL3545411.00infobox
LomitapideChEMBLmesylate: ChEMBL21056621.00infobox
LomitapideChemSpider8028764 N1.00infobox
LomitapideChemSpidermesylate: 94493351.00infobox
LomitapideCompTox Dashboard (EPA)DTXSID501712941.00infobox
LomitapideDrugBankDB08827 Y1.00infobox
LomitapideDrugBankmesylate: DBSALT0001101.00infobox
LomitapideFormulaC39H37F6N3O21.00infobox
LomitapideIUPHAR/BPS74391.00infobox
LomitapideKEGGD09637 Y1.00infobox
LomitapideKEGGmesylate: D096381.00infobox
LomitapideLegal statusUS: ℞-only1.00infobox
LomitapideLegal statusEU: Rx-only1.00infobox
LomitapideLicense dataEU EMA: by INN1.00infobox
LomitapideLicense dataUS DailyMed: Lomitapide1.00infobox
LomitapideLicense dataUS FDA: Lomitapide1.00infobox
LomitapideMolar mass693.734 g·mol−11.00infobox
LomitapideOther namesAEGR-773, BMS-2010381.00infobox
LomitapidePubChem CID98530531.00infobox
LomitapidePubChem CIDmesylate: 112743331.00infobox
LomitapideRoutes of administrationBy mouth1.00infobox
LomitapideTrade namesJuxtapid (US), Lojuxta (EU)1.00infobox
LomitapideUNII82KUB0583F1.00infobox
LomitapideUNIImesylate: X4S83CP54E1.00infobox

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