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Lomitapide: Overview, Mechanism of action & Side effects

Lomitapide, sold under the brand name Juxtapid in the US and Lojuxta in the EU, is a medication used as a lipid-lowering agent for the treatment of familial hypercholesterolemia, developed by Aegerion Pharmaceuticals. It has been tested in clinical trials as single treatment and in combinations with atorvastatin, ezetimibe and fenofibrate.

Language: English [EN]
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Lomitapide topic overview

The analysis highlights Overview, Mechanism of action and Side effects as prominent areas in the source structure around Lomitapide.

Related topics
16
Source areas
3
Connected nodes
19
Extracted relationships
44
Concept neighborhoods
14
Bridge connections
19

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 12 topics
Mechanism of action · 2 topics
Side effects · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
ATC code
C10AX12 (WHO)
CAS Number
182431-12-5 Y · mesylate: 202914-84-9
ChEBI
CHEBI:72297 N · mesylate: CHEBI:72299
ChEMBL
ChEMBL354541 · mesylate: ChEMBL2105662
ChemSpider
8028764 N · mesylate: 9449335

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Mechanism of action

Side effects

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Lomitapide connects Entity context

The extracted context around Lomitapide shows recurring relationship patterns in the source. For example, Lomitapide → Aegerion, FDA, HoFH, In December, MTP, MTTP, VLDL Another extracted example is Lomitapide → Archived, Drug Information Portal, January, Medicine, National Library. Use these groups to spot repeated connection types before inspecting the individual relationships.

Lomitapide

Top relations

related to Mechanism of action · 7
Lomitapide → Aegerion, FDA, HoFH, In December, MTP, MTTP, VLDL
related to External links · 5
Lomitapide → Archived, Drug Information Portal, January, Medicine, National Library
License data · 3
Lomitapide → EU EMA: by INN, US DailyMed: Lomitapide, US FDA: Lomitapide
CAS Number · 2
Lomitapide → 182431-12-5 Y, mesylate: 202914-84-9
ChEBI · 2
Lomitapide → CHEBI:72297 N, mesylate: CHEBI:72299
ChEMBL · 2
Lomitapide → ChEMBL354541, mesylate: ChEMBL2105662
ChemSpider · 2
Lomitapide → 8028764 N, mesylate: 9449335
DrugBank · 2
Lomitapide → DB08827 Y, mesylate: DBSALT000110
KEGG · 2
Lomitapide → D09637 Y, mesylate: D09638
Legal status · 2
Lomitapide → EU: Rx-only, US: ℞-only

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

us lipid-lowering familial hypercholesterolemia approved lipoprotein hofh fda drug treatment ldl name juxtapid lojuxta eu administration aegerion december 2012 homozygous

Lomitapide relationships Subject–Predicate–Object triples

TTTA extracted 44 structured relationships around Lomitapide. Examples in this analysis include Lomitapide → 3D model (JSmol) → Interactive image and Lomitapide → ATC code → C10AX12 (WHO). The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Lomitapide3D model (JSmol)Interactive image1.00infobox
LomitapideATC codeC10AX12 (WHO)1.00infobox
LomitapideCAS Number182431-12-5 Y1.00infobox
LomitapideCAS Numbermesylate: 202914-84-91.00infobox
LomitapideChEBICHEBI:72297 N1.00infobox
LomitapideChEBImesylate: CHEBI:722991.00infobox
LomitapideChEMBLChEMBL3545411.00infobox
LomitapideChEMBLmesylate: ChEMBL21056621.00infobox
LomitapideChemSpider8028764 N1.00infobox
LomitapideChemSpidermesylate: 94493351.00infobox
LomitapideCompTox Dashboard (EPA)DTXSID501712941.00infobox
LomitapideDrugBankDB08827 Y1.00infobox
LomitapideDrugBankmesylate: DBSALT0001101.00infobox
LomitapideFormulaC39H37F6N3O21.00infobox
LomitapideIUPHAR/BPS74391.00infobox
LomitapideKEGGD09637 Y1.00infobox
LomitapideKEGGmesylate: D096381.00infobox
LomitapideLegal statusUS: ℞-only1.00infobox
LomitapideLegal statusEU: Rx-only1.00infobox
LomitapideLicense dataEU EMA: by INN1.00infobox
LomitapideLicense dataUS DailyMed: Lomitapide1.00infobox
LomitapideLicense dataUS FDA: Lomitapide1.00infobox
LomitapideMolar mass693.734 g·mol−11.00infobox
LomitapideOther namesAEGR-773, BMS-2010381.00infobox
LomitapidePubChem CID98530531.00infobox
LomitapidePubChem CIDmesylate: 112743331.00infobox
LomitapideRoutes of administrationBy mouth1.00infobox
LomitapideTrade namesJuxtapid (US), Lojuxta (EU)1.00infobox
LomitapideUNII82KUB0583F1.00infobox
LomitapideUNIImesylate: X4S83CP54E1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Lomitapide bring nearby vocabulary together. In this analysis, examples include Approved, Familial and Fda. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Lomitapide
    • Approved
    • Familial
    • Fda
    • Hofh
    • Hypercholesterolemia
    • Lipid-lowering
    • Lipoprotein
    • Us
    • Adjunct
    • Administration
    • Aegerion
    • December
  • lomitapide
    • Approved
    • Familial
    • Fda
    • Hofh
    • Hypercholesterolemia
    • Lipid-lowering
    • Lipoprotein
    • Us
    • Adjunct
    • Administration
    • Aegerion
    • December
  • lipid-lowering agent
    • Brand
    • Developed
    • Medication
    • Pharmaceuticals
    • Sold
    • Used
    • Adjunct
    • Aegerion
    • Diet
    • Low-fat
    • Lomitapide
    • Approved
  • homozygous familial hypercholesterolemia
    • Hypercholesterolemia
    • Aegerion
    • December
    • Hofh
    • Homozygous
    • Lomitapide
    • Approved
    • Drug
    • Fda
    • Lipid-lowering
    • Us
    • Adjunct
  • orphan drug
    • December
    • Homozygous
    • Approved
    • Familial
    • Fda
    • Hofh
    • Hypercholesterolemia
    • Cholesterol
    • Lomitapide
    • Adjunct
    • Administration
    • Diet
  • non-high-density lipoprotein (non-hdl) cholesterol
    • Lomitapide
    • December
    • Hofh
    • Homozygous
    • Ldl
    • Us
    • Apheresis
    • Drug
    • Familial
    • Fda
    • Hypercholesterolemia
    • Lipoprotein
  • ldl cholesterol
    • Hofh
    • Lipoprotein
    • Apheresis
    • Cholesterol
    • December
    • Homozygous
    • Ldl
    • Lomitapide
    • Adjunct
    • Diet
    • Drug
    • Familial
  • cholesterol
    • December
    • Homozygous
    • Ldl
    • Drug
    • Familial
    • Fda
    • Hofh
    • Hypercholesterolemia
    • Lipoprotein
    • Us
    • Lomitapide

Connections between topic areas Semantic bridges

For Lomitapide, one of the stronger structural bridges in this analysis connects Lomitapide with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Lomitapide — Overview · splits 7 ⟂ 13
Lomitapide — Mechanism of action · splits 17 ⟂ 3
Lomitapide — Side effects · splits 17 ⟂ 3

Map overview Semantic statistics

Lomitapide

Nodes20
Edges19
Triples44
Avg. degree1.9
Density0.1
Components1

Source & methodology

TTTA analyzes the structure around Lomitapide to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview, Mechanism of action & Side effects, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Lomitapide · EN edition · Analysis: TopicsToTalkAbout

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