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XPB

XPB (xeroderma pigmentosum type B) is an ATP-dependent DNA helicase in humans that is a part of the TFIIH transcription factor complex.

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5.6.2.4
Aliases
ERCC3, excision repair cross-complementation group 3, BTF2, GTF2H, RAD25, TFIIH, XPB, TTD2, ERCC excision repair 3, TFIIH core complex helicase subunit, Ssl2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4ERN, 5IY9, 5IVW, 5IY7, 5IY8, 5IY6
Band
2q14.3 · 18|18 B1
Bgee
sural nerve · right hemisphere of cerebellum · right uterine tube · gastric mucosa · gonad
BioGPS
More reference expression data

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Map overview Semantic statistics

XPB

Nodes32
Edges31
Triples169
Avg. degree1.94
Density0.0625
Components1

How this topic connects Entity context

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XPB

Top relations

Gene ontology · 64
XPB → 3'-5' DNA helicase activity, 7-methylguanosine mRNA capping, apoptotic process, ATP binding, ATP-dependent activity, acting on DNA, ATPase activity, cellular response to DNA damage stimulus, damaged DNA binding, DNA binding, DNA helicase activity, DNA repair, DNA topological change, DNA translocase activity, embryonic organ development, global genome nucleotide-excision repair, hair cell differentiation, helicase activity, hydrolase activity, nucleoplasm, nucleotide binding
Bgee · 19
XPB → anterior pituitary, body of uterus, canal of the cervix, endothelial cell of lymphatic vessel, epiblast, ganglionic eminence, gastric mucosa, gonad, granulocyte, lumbar spinal ganglion, medullary collecting duct, renal corpuscle, right hemisphere of cerebellum, right uterine tube, spermatid, sural nerve, tail of embryo, ventricular zone, yolk sac
RNA expression pattern · 19
XPB → anterior pituitary, body of uterus, canal of the cervix, endothelial cell of lymphatic vessel, epiblast, ganglionic eminence, gastric mucosa, gonad, granulocyte, lumbar spinal ganglion, medullary collecting duct, renal corpuscle, right hemisphere of cerebellum, right uterine tube, spermatid, sural nerve, tail of embryo, ventricular zone, yolk sac
related to Function · 14
XPB → Cockayne, DNA, ERCC3, Mutant XPB, Mutations, NER, Purified XPB, Such, TCR, The, UV, UV-induced, XP, XPCS
related to Interactions · 9
XPB → BCR, CDK7, ERCC2, GTF2H1, GTF2H2, GTF2H4, GTF2H5, P53, PSMC5
related to External links · 5
XPB → GeneReviews/NIH/NCBI/UW, Medicine Medical Subject Headings, MeSH, National Library, Xeroderma PigmentosumXPBC-ERCC-3
related to Structure · 5
XPB → Dr, John Tainer, The, The Scripps Research Institute, X-ray
related to Disorders · 4
XPB → Cockayne's, Mutations, Xeroderma, XPA-XPG
Band · 2
XPB → 18|18 B1, 2q14.3
Chr. · 2
XPB → Chromosome 18 (mouse), Chromosome 2 (human)

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Important terminology

bp dna chr human band gene helicase tfiih chromosome ercc3 transcription xeroderma pigmentosum complex factor location function repair mouse protein

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
XPB5.6.2.41.00infobox
XPBAliasesERCC3, excision repair cross-complementation group 3, BTF2, GTF2H, RAD25, TFIIH, XPB, TTD2, ERCC excision repair 3, TFIIH core complex helicase subunit, Ssl21.00infobox
XPBAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4ERN, 5IY9, 5IVW, 5IY7, 5IY8, 5IY61.00infobox
XPBBand2q14.31.00infobox
XPBBand18|18 B11.00infobox
XPBBgeesural nerve1.00infobox
XPBBgeeright hemisphere of cerebellum1.00infobox
XPBBgeeright uterine tube1.00infobox
XPBBgeegastric mucosa1.00infobox
XPBBgeegonad1.00infobox
XPBBgeegranulocyte1.00infobox
XPBBgeeganglionic eminence1.00infobox
XPBBgeebody of uterus1.00infobox
XPBBgeeanterior pituitary1.00infobox
XPBBgeecanal of the cervix1.00infobox
XPBBgeespermatid1.00infobox
XPBBgeerenal corpuscle1.00infobox
XPBBgeeendothelial cell of lymphatic vessel1.00infobox
XPBBgeeventricular zone1.00infobox
XPBBgeeepiblast1.00infobox
XPBBgeetail of embryo1.00infobox
XPBBgeemedullary collecting duct1.00infobox
XPBBgeelumbar spinal ganglion1.00infobox
XPBBgeeyolk sac1.00infobox
XPBBioGPSMore reference expression data1.00infobox
XPBChr.Chromosome 2 (human)1.00infobox
XPBChr.Chromosome 18 (mouse)1.00infobox
XPBDatabasesNCBI: entry; OMA: entry1.00infobox
XPBEnd127,294,166 bp1.00infobox
XPBEnd32,403,204 bp1.00infobox

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