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ERCC5: Applications & Products

DNA repair protein complementing XP-G cells is a protein that in humans is encoded by the ERCC5 gene.

Language: English [EN]
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ERCC5 topic overview

The analysis highlights Applications and Products as prominent areas in the source structure around ERCC5.

Related topics
16
Source areas
5
Connected nodes
21
Extracted relationships
115
Concept neighborhoods
14
Bridge connections
21

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Mouse model · 6 topics
Function · 4 topics
Interactions · 2 topics
Overview · 2 topics
Syndromes · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
ERCC5, COFS3, ERCM2, UVDR, XPG, XPGC, ERCC5-201, excision repair cross-complementation group 5, ERCC excision repair 5, endonuclease
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5EKF, 5EKG
Band
13q33.1 · 1 C1.1|1 23.55 cM
Bgee
granulocyte · Achilles tendon · body of pancreas · skin of leg · skin of abdomen
BioGPS
More reference expression data
Chr.
Chromosome 13 (human) · Chromosome 1 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Syndromes

Mouse model

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How ERCC5 connects Entity context

The extracted context around ERCC5 shows recurring relationship patterns in the source. For example, ERCC5 → bubble DNA binding, catalytic activity, cellular response to DNA damage stimulus, DNA binding, DNA repair, DNA replication factor A complex, double-stranded DNA binding, endodeoxyribonuclease activity, endonuclease activity, hydrolase activity, hydrolase activity, acting on ester bonds, metal ion binding, negative regulation of apoptotic process, nuclease activity, nucleoplasm, nucleotide-excision repair, nucleotide-excision repair complex, nucleotide-excision repair, DNA incision, nucleotide-excision repair, DNA incision, 3'-to lesion, nucleotide-excision repair, DNA incision, 5'-to lesion Another extracted example is ERCC5 → Achilles tendon, anterior pituitary, body of pancreas, ciliary body, corneal stroma, ganglionic eminence, genital tubercle, granulocyte, mucosa of transverse colon, neural layer of retina, right lobe of liver, right lung, Rostral migratory stream, skin of abdomen, skin of leg, stroma of bone marrow, supraoptic nucleus, tail of embryo, tibial nerve, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

ERCC5

Top relations

Gene ontology · 35
ERCC5 → bubble DNA binding, catalytic activity, cellular response to DNA damage stimulus, DNA binding, DNA repair, DNA replication factor A complex, double-stranded DNA binding, endodeoxyribonuclease activity, endonuclease activity, hydrolase activity, hydrolase activity, acting on ester bonds, metal ion binding, negative regulation of apoptotic process, nuclease activity, nucleoplasm, nucleotide-excision repair, nucleotide-excision repair complex, nucleotide-excision repair, DNA incision, nucleotide-excision repair, DNA incision, 3'-to lesion, nucleotide-excision repair, DNA incision, 5'-to lesion
Bgee · 20
ERCC5 → Achilles tendon, anterior pituitary, body of pancreas, ciliary body, corneal stroma, ganglionic eminence, genital tubercle, granulocyte, mucosa of transverse colon, neural layer of retina, right lobe of liver, right lung, Rostral migratory stream, skin of abdomen, skin of leg, stroma of bone marrow, supraoptic nucleus, tail of embryo, tibial nerve, ventricular zone
RNA expression pattern · 20
ERCC5 → Achilles tendon, anterior pituitary, body of pancreas, ciliary body, corneal stroma, ganglionic eminence, genital tubercle, granulocyte, mucosa of transverse colon, neural layer of retina, right lobe of liver, right lung, Rostral migratory stream, skin of abdomen, skin of leg, stroma of bone marrow, supraoptic nucleus, tail of embryo, tibial nerve, ventricular zone
related to Function · 5
ERCC5 → Cockayne, Excision, Multiple, Mutations, UV-induced DNA
related to Mouse model · 5
ERCC5 → An Ercc5, Dietary, DNA, These, Xpg
related to Syndromes · 5
ERCC5 → Cockayne, CS, Mutational, XP, Xpg
Band · 2
ERCC5 → 1 C1.1|1 23.55 cM, 13q33.1
Chr. · 2
ERCC5 → Chromosome 1 (mouse), Chromosome 13 (human)
End · 2
ERCC5 → 102,875,995 bp, 44,220,420 bp
Aliases · 1
ERCC5 → ERCC5, COFS3, ERCM2, UVDR, XPG, XPGC, ERCC5-201, excision repair cross-complementation group 5, ERCC excision repair 5, endonuclease

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

dna bp gene chr human band repair mouse chromosome 13 xpg damage aging location endonuclease mutant protein excision function external

ERCC5 relationships Subject–Predicate–Object triples

TTTA extracted 115 structured relationships around ERCC5. Examples in this analysis include ERCC5 → Aliases → ERCC5, COFS3, ERCM2, UVDR, XPG, XPGC, ERCC5-201, excision repair cross-complementation group 5, ERCC excision repair 5, endonuclease and ERCC5 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5EKF, 5EKG. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
ERCC5AliasesERCC5, COFS3, ERCM2, UVDR, XPG, XPGC, ERCC5-201, excision repair cross-complementation group 5, ERCC excision repair 5, endonuclease1.00infobox
ERCC5Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5EKF, 5EKG1.00infobox
ERCC5Band13q33.11.00infobox
ERCC5Band1 C1.1|1 23.55 cM1.00infobox
ERCC5Bgeegranulocyte1.00infobox
ERCC5BgeeAchilles tendon1.00infobox
ERCC5Bgeebody of pancreas1.00infobox
ERCC5Bgeeskin of leg1.00infobox
ERCC5Bgeeskin of abdomen1.00infobox
ERCC5Bgeeright lobe of liver1.00infobox
ERCC5Bgeeanterior pituitary1.00infobox
ERCC5Bgeeright lung1.00infobox
ERCC5Bgeemucosa of transverse colon1.00infobox
ERCC5Bgeetibial nerve1.00infobox
ERCC5BgeeRostral migratory stream1.00infobox
ERCC5Bgeegenital tubercle1.00infobox
ERCC5Bgeetail of embryo1.00infobox
ERCC5Bgeestroma of bone marrow1.00infobox
ERCC5Bgeeganglionic eminence1.00infobox
ERCC5Bgeeventricular zone1.00infobox
ERCC5Bgeeneural layer of retina1.00infobox
ERCC5Bgeecorneal stroma1.00infobox
ERCC5Bgeeciliary body1.00infobox
ERCC5Bgeesupraoptic nucleus1.00infobox
ERCC5BioGPSMore reference expression data1.00infobox
ERCC5Chr.Chromosome 13 (human)1.00infobox
ERCC5Chr.Chromosome 1 (mouse)1.00infobox
ERCC5DatabasesNCBI: entry; OMA: entry1.00infobox
ERCC5End102,875,995 bp1.00infobox
ERCC5End44,220,420 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around ERCC5 bring nearby vocabulary together. In this analysis, examples include Gene, Xpg and Mouse. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • ERCC5
    • Gene
    • Xpg
    • Mouse
    • Repair
    • Function
    • Group
    • Model
    • Protein
    • Search
    • Cause
    • Endonuclease
    • Excision
  • ercc5
    • Gene
    • Xpg
    • Mouse
    • Repair
    • Function
    • Group
    • Model
    • Protein
    • Search
    • Cause
    • Endonuclease
    • Excision
  • gene
    • Location
    • Chromosome
    • Human
    • Mouse
    • Repair
    • Bp
    • Chr
    • C1
    • End
    • Function
    • Group
    • Protein
  • endonuclease
    • Excision
    • Repair
    • Function
    • Group
    • Search
    • Location
    • Chromosome
    • Human
    • Mouse
    • Bp
    • Chr
    • External
  • dna
    • Damage
    • Repair
    • Protein
    • Aging
    • Endonuclease
    • Excision
    • Mice
    • Mutant
    • Gene
    • Ercc5
    • C1
    • End
  • nucleotide excision repair
    • Endonuclease
    • Repair
    • Function
    • Group
    • Search
    • Location
    • Chromosome
    • Human
    • Mouse
    • Bp
    • Chr
    • External
  • dna damage
    • Damage
    • Dna
    • Aging
    • Mice
    • Repair
    • Mutant
    • Protein
    • Endonuclease
    • Excision
    • End
    • Entry
    • Function
  • dna damage theory of aging
    • Mutant
    • Damage
    • Dna
    • Aging
    • Mice
    • Repair
    • Protein
    • Endonuclease
    • Excision
    • Cachexia
    • End
    • Entry

Connections between topic areas Semantic bridges

For ERCC5, one of the stronger structural bridges in this analysis connects ERCC5 with Mouse model. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
ERCC5Mouse model · splits 15 ⟂ 7
ERCC5Function · splits 17 ⟂ 5
ERCC5Overview · splits 19 ⟂ 3
ERCC5Syndromes · splits 19 ⟂ 3
ERCC5Interactions · splits 19 ⟂ 3

Map overview Semantic statistics

ERCC5

Nodes22
Edges21
Triples115
Avg. degree1.91
Density0.090909
Components1

Source & methodology

TTTA analyzes the structure around ERCC5 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications & Products, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — ERCC5 · EN edition · Analysis: TopicsToTalkAbout

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