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DRIP-seq

DRIP-seq (DRIP-sequencing) is a technology for genome-wide profiling of a type of DNA-RNA hybrid called an "R-loop". DRIP-seq utilizes a sequence-independent but structure-specific antibody for DNA-RNA immunoprecipitation (DRIP) to capture R-loops for massively parallel DNA sequencing.

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Overview

Introduction

Uses and Current Research

Workflow of DRIP-seq

Computational Analysis

Other R-loop Profiling Methods

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Map overview Semantic statistics

DRIP-seq

Nodes47
Edges46
Triples73
Avg. degree1.96
Density0.042553
Components1

How this topic connects Entity context

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DRIP-seq

Top relations

has method · 16
DRIP-seq → Although, An, CpG, DNA, DRIP-chip, DRIVE-seq, However, MBP-RNASEH1, Non-denaturing, R-loop, R-loops, RNA, RNA In Vitro Enrichment, S9, The, This
related to Computational Analysis · 13
DRIP-seq → ChIP-seq, DRIP, DROPA, If, QmRLFS-finder, R-loop, R-loopBase, R-loops, RLBase, RNase H1-treated, Several, To, Typically
related to Introduction · 12
DRIP-seq → AID, An R-loop, APOBEC, CpG, DNA, DNA-RNA, However, R-loop, R-loops, Therefore, They, Under
related to Limitations · 11
DRIP-seq → DNA, DRIVE-seq, Due, GC-rich, However, In, Moreover, On, R-loop, R-loops, Sequencing
related to Uses and Current Research · 10
DRIP-seq → CpG, DNA, DNA-RNA, Identifying R-loop, Indirectly, It, Particularly, R-loop, R-loops, These
related to Immunoprecipitation · 7
DRIP-seq → DNA-RNA, Fragmented, S9, The, The S9, This, Thus
is a · 1
DRIP-seq → rapid obtention of the data

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Important terminology

r-loops r-loop dna dna-rna sequencing immunoprecipitation used s9 regions mab formation gdna methods profiling genome antibody hybrids also relies fragments

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
DRIP-seqis arapid obtention of the data0.90text
AIDinstance ofR-loops can cause genome instability by exposing single-stranded DNA to endogenous damages exerted by the action of enzymes0.80text
APOBECinstance ofR-loops can cause genome instability by exposing single-stranded DNA to endogenous damages exerted by the action of enzymes0.80text
or overexposure to chemically reactive speciesinstance ofR-loops can cause genome instability by exposing single-stranded DNA to endogenous damages exerted by the action of enzymes0.80text
DRIP-seqhas methodAlthough0.60section
DRIP-seqhas methodR-loop0.60section
DRIP-seqhas methodNon-denaturing0.60section
DRIP-seqhas methodThis0.60section
DRIP-seqhas methodCpG0.60section
DRIP-seqhas methodR-loops0.60section
DRIP-seqhas methodDNA0.60section
DRIP-seqhas methodRNA In Vitro Enrichment0.60section

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