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Dofetilide

Dofetilide is a class III antiarrhythmic agent. It is marketed under the trade name Tikosyn by Pfizer, and is available in the United States in capsules containing 125, 250, and 500 μg of dofetilide. It is not available in Europe or Australia.

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Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
C01BD04 (WHO)
Bioavailability
96% (oral)
CAS Number
115256-11-6 Y
ChEBI
CHEBI:4681 Y

Topics to explore

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Overview

Medical uses

Contraindications

Adverse effects

Pharmacology

Advanced semantic analysis

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Map overview Semantic statistics

Dofetilide

Nodes45
Edges44
Triples51
Avg. degree1.96
Density0.044444
Components1

How this topic connects Entity context

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Dofetilide

Top relations

related to Medical uses · 11
Dofetilide → After, Arrhythmias, Based, Because, CHF-related, Danish Investigations, DIAMOND, Europe, LV, Mortality, Pfizer
related to Contraindications · 5
Dofetilide → After, If, Prior, QT, QTc
related to Pharmacokinetics · 5
Dofetilide → Due, Intravenous, Peak, The, United States
has effect · 3
Dofetilide → Patients, The, Torsades
related to history · 2
Dofetilide → After, US FDA
related to Mechanism of action · 2
Dofetilide → IKr, This
3D model (JSmol) · 1
Dofetilide → Interactive image
AHFS/Drugs.com · 1
Dofetilide → Monograph
ATC code · 1
Dofetilide → C01BD04 (WHO)
Bioavailability · 1
Dofetilide → 96% (oral)

Important terminology Word statistics

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Important terminology

cyp3a4 individuals qtc available however dose atrial fibrillation patients first qt torsades de pointes three days 500 creatinine drugs oral

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Dofetilide3D model (JSmol)Interactive image1.00infobox
DofetilideAHFS/Drugs.comMonograph1.00infobox
DofetilideATC codeC01BD04 (WHO)1.00infobox
DofetilideBioavailability96% (oral)1.00infobox
DofetilideCAS Number115256-11-6 Y1.00infobox
DofetilideChEBICHEBI:4681 Y1.00infobox
DofetilideChEMBLChEMBL473 Y1.00infobox
DofetilideChemSpider64435 Y1.00infobox
DofetilideCompTox Dashboard (EPA)DTXSID50464331.00infobox
DofetilideDrugBankDB00204 Y1.00infobox
DofetilideECHA InfoCard100.166.4411.00infobox
DofetilideElimination half-life10 hours1.00infobox
DofetilideFormulaC19H27N3O5S21.00infobox
DofetilideIUPHAR/BPS26041.00infobox
DofetilideKEGGD00647 Y1.00infobox
DofetilideMedlinePlusa6012351.00infobox
DofetilideMolar mass441.56 g·mol−11.00infobox
DofetilideProtein binding60% -70%1.00infobox
DofetilidePubChem CID713291.00infobox
DofetilideTrade namesTikosyn1.00infobox
DofetilideUNIIR4Z9X1N2ND1.00infobox
Dofetilidecausesan increased rate of potentially life-threatening arrhythmias in comparison to other therapies0.90text
Dofetilideis aclass III antiarrhythmic agent0.90text

Related concept clusters Concept neighborhoods

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