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DNA re-replication

DNA re-replication (or simply rereplication) is an undesirable and possibly fatal occurrence in eukaryotic cells in which the genome is replicated more than once per cell cycle. Rereplication is believed to lead to genomic instability and has been implicated in the pathologies of a variety of human cancers. To prevent rereplication, eukaryotic cells have…

Events, Origin licensing & Replication regulation

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Overview

Initiating replication at origins

Origin licensing

Two-state model for DNA replication regulation

Replication regulation

Consequences of rereplication in eukaryotic cells

Preventing rereplication

Rereplication in cancer

Endoreduplication

Advanced semantic analysis

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Map overview Semantic statistics

DNA re-replication

Nodes62
Edges61
Triples26
Avg. degree1.97
Density0.032258
Components1

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DNA re-replication

Top relations

related to Preventing rereplication · 26
DNA re-replication → Ataxia, ATM, ATM/ATR-regulated DNA, ATR, Cdt1, Cells, Damage, DNA, DSB, DSBs, G2/M, H2AX, MCM2, Myc, Overexpression, Rad3, RB, RPA2, Ser, SMC1

Important terminology Word statistics

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Important terminology

dna replication rereplication cdt1 cell cells origins cycle mechanisms origin cdc6 pre-rc re-replication regulation cdk damage prevent licensing endoreduplication g1

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
DNA re-replicationrelated to Preventing rereplicationCells0.60section
DNA re-replicationrelated to Preventing rereplicationG2/M0.60section
DNA re-replicationrelated to Preventing rereplicationWhen0.60section
DNA re-replicationrelated to Preventing rereplicationU-2-OS0.60section
DNA re-replicationrelated to Preventing rereplicationRB0.60section
DNA re-replicationrelated to Preventing rereplicationATM/ATR-regulated DNA0.60section
DNA re-replicationrelated to Preventing rereplicationThis0.60section
DNA re-replicationrelated to Preventing rereplicationSer0.60section
DNA re-replicationrelated to Preventing rereplicationH2AX0.60section
DNA re-replicationrelated to Preventing rereplicationSMC10.60section
DNA re-replicationrelated to Preventing rereplicationThe DNA0.60section
DNA re-replicationrelated to Preventing rereplicationDamage0.60section

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    Min side: 3
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