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Geminin: History, Function & Overview
Geminin, DNA replication inhibitor, also known as GMNN, is a protein in humans encoded by the GMNN gene. A nuclear protein present in most eukaryotes and highly conserved across species, numerous functions have been elucidated for geminin including roles in metazoan cell cycle, cellular proliferation, cell lineage commitment, and neural differentiation.…
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Geminin topic overview
The analysis highlights History, Function and Overview as prominent areas in the source structure around Geminin.
Related topics
28
Source areas
4
Connected nodes
32
Extracted relationships
103
Concept neighborhoods
17
Bridge connections
32
What this topic covers Research coverage
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Overview · 13 topics
Function · 9 topics
History · 4 topics
Structure · 2 topics
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Aliases
GMNN, Gem, MGORS6, geminin, DNA replication inhibitor, geminin DNA replication inhibitor
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1T6F, 1UII, 2LP0, 2WVR, 4BRY
Band
6p22.3 · 13|13 A3.1
Bgee
oocyte · body of pancreas · secondary oocyte · gonad · mucosa of transverse colon
BioGPS
More reference expression data
Chr.
Chromosome 6 (human) · Chromosome 13 (mouse)
Explore all related topics Closing gaps
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
How Geminin connects Entity context
Entity context groups extracted connections by relationship type. Counts show recurrence in the analyzed source; the examples are research signals, not claims about importance.
The extracted context around Geminin shows recurring relationship patterns in the source. For example, Geminin → animal organ morphogenesis, cell cycle, chromatin binding, cytoplasm, cytosol, DNA replication preinitiation complex assembly, G1/S transition of mitotic cell cycle, histone deacetylase binding, negative regulation of cell cycle, negative regulation of DNA replication, negative regulation of DNA-dependent DNA replication, negative regulation of transcription, DNA-templated, nucleoplasm, nucleus, positive regulation of chromatin binding, protein binding, protein-containing complex assembly, regulation of DNA replication, transcription corepressor activity Another extracted example is Geminin → blastocyst, body of pancreas, embryo, epiblast, fetal liver hematopoietic progenitor cell, ganglionic eminence, gonad, medial ganglionic eminence, morula, mucosa of sigmoid colon, mucosa of transverse colon, oocyte, Paneth cell, primitive streak, rectum, secondary oocyte, ventricular zone, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.
Geminin
Top relations
Gene ontology· 19
Geminin → animal organ morphogenesis, cell cycle, chromatin binding, cytoplasm, cytosol, DNA replication preinitiation complex assembly, G1/S transition of mitotic cell cycle, histone deacetylase binding, negative regulation of cell cycle, negative regulation of DNA replication, negative regulation of DNA-dependent DNA replication, negative regulation of transcription, DNA-templated, nucleoplasm, nucleus, positive regulation of chromatin binding, protein binding, protein-containing complex assembly, regulation of DNA replication, transcription corepressor activity
Bgee· 18
Geminin → blastocyst, body of pancreas, embryo, epiblast, fetal liver hematopoietic progenitor cell, ganglionic eminence, gonad, medial ganglionic eminence, morula, mucosa of sigmoid colon, mucosa of transverse colon, oocyte, Paneth cell, primitive streak, rectum, secondary oocyte, ventricular zone, yolk sac
RNA expression pattern· 18
Geminin → blastocyst, body of pancreas, embryo, epiblast, fetal liver hematopoietic progenitor cell, ganglionic eminence, gonad, medial ganglionic eminence, morula, mucosa of sigmoid colon, mucosa of transverse colon, oocyte, Paneth cell, primitive streak, rectum, secondary oocyte, ventricular zone, yolk sac
related to External links· 12
Geminin → GMNN, Human Geminin, Medicine Medical Subject Headings, MeSH, Mouse Geminin, National Library, O75496, O88513, Overview, PDB, PDBe-KB, UniProt
Relationships are represented as Subject → Predicate → Object triples. Confidence describes extraction strength, not the real-world importance of a relationship; lower-confidence rows may be contextual rather than explicit.
TTTA extracted 103 structured relationships around Geminin. Examples in this analysis include Geminin → Aliases → GMNN, Gem, MGORS6, geminin, DNA replication inhibitor, geminin DNA replication inhibitor and Geminin → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1T6F, 1UII, 2LP0, 2WVR, 4BRY. The table shows each extracted connection, where it came from and its confidence.
Subject
Predicate
Object
Confidence
Src
Geminin
Aliases
GMNN, Gem, MGORS6, geminin, DNA replication inhibitor, geminin DNA replication inhibitor
1.00
infobox
Geminin
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1T6F, 1UII, 2LP0, 2WVR, 4BRY
1.00
infobox
Geminin
Band
6p22.3
1.00
infobox
Geminin
Band
13|13 A3.1
1.00
infobox
Geminin
Bgee
oocyte
1.00
infobox
Geminin
Bgee
body of pancreas
1.00
infobox
Geminin
Bgee
secondary oocyte
1.00
infobox
Geminin
Bgee
gonad
1.00
infobox
Geminin
Bgee
mucosa of transverse colon
1.00
infobox
Geminin
Bgee
ventricular zone
1.00
infobox
Geminin
Bgee
embryo
1.00
infobox
Geminin
Bgee
rectum
1.00
infobox
Geminin
Bgee
ganglionic eminence
1.00
infobox
Geminin
Bgee
mucosa of sigmoid colon
1.00
infobox
Geminin
Bgee
primitive streak
1.00
infobox
Geminin
Bgee
fetal liver hematopoietic progenitor cell
1.00
infobox
Geminin
Bgee
morula
1.00
infobox
Geminin
Bgee
yolk sac
1.00
infobox
Geminin
Bgee
Paneth cell
1.00
infobox
Geminin
Bgee
medial ganglionic eminence
1.00
infobox
Geminin
Bgee
blastocyst
1.00
infobox
Geminin
Bgee
epiblast
1.00
infobox
Geminin
BioGPS
More reference expression data
1.00
infobox
Geminin
Chr.
Chromosome 6 (human)
1.00
infobox
Geminin
Chr.
Chromosome 13 (mouse)
1.00
infobox
Geminin
Databases
NCBI: entry; OMA: entry
1.00
infobox
Geminin
End
24,786,099 bp
1.00
infobox
Geminin
End
24,945,906 bp
1.00
infobox
Geminin
Ensembl
ENSG00000112312
1.00
infobox
Geminin
Entrez
51053
1.00
infobox
No triples extracted yet.
Related concept clusters Concept neighborhoods
Concept neighborhoods group terms that sit near one another in the extracted graph. They are useful for discovering adjacent language and context, but proximity does not by itself imply a factual relationship.
The concept neighborhoods around Geminin bring nearby vocabulary together. In this analysis, examples include Cell, Replication and Neural. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
Geminin
Cell
Replication
Neural
Cycle
Complex
Lines
Protein
Also
Available
Cancer
Chromatin
Inhibitor
geminin
Cell
Replication
Neural
Cycle
Complex
Lines
Protein
Also
Available
Cancer
Chromatin
Inhibitor
cellular proliferation
Species
Cycle
Protein
Differentiation
Nuclear
O75496
O88513
Chromatin
Function
G1
Inhibitor
Location
dna re-replication
Inhibitor
Replication
Gene
Gmnn
Known
Human
Function
Location
Phase
Chromosome
Cell
Bp
dna replication
Inhibitor
Replication
Gene
Gmnn
Known
Human
Function
Location
Phase
Chromosome
Cell
Bp
function
Inhibitor
Location
Chromosome
Gene
Gmnn
Bp
Chr
External
Replication
Cdt1
Human
O75496
pre-replication complex
G1
Mitosis
Replication
Geminin
O75496
O88513
Species
Function
Inhibitor
Location
Mouse
Uniprot
anaphase-promoting complex
G1
Mitosis
Replication
Geminin
O75496
O88513
Species
Function
Inhibitor
Location
Mouse
Uniprot
Connections between topic areas Semantic bridges
Semantic bridges connect parts of the graph that would otherwise be more separate. A bridge is a structural signal in this analysis, not a claim that the two topic areas are equivalent.
For Geminin, one of the stronger structural bridges in this analysis connects Geminin with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.
Geminin
Nodes33
Edges32
Triples103
Avg. degree1.94
Density0.060606
Components1
Source & methodology
TTTA analyzes the structure around Geminin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
