COX10

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Clinical Significance

Phenotypes Tubulopathy Leukodystrophy Leigh syndrome Cardiomyopathy

13 related topics

Structure

Chromosome 17 Amino acids 3' untranslated region Open reading frame Exons

11 related topics

Overview

Enzyme Gene Cytochrome c oxidase Mitochondrial respiratory chain Catalyzes

25 related topics

Function

Biosynthetic pathway Farnesylation Vinyl group Heme B Heme O

5 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.5.1.141: ↗
Aliases: COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor, cytochrome c oxidase assembly factor heme A:farnesyltransferase MC4DN3
Band: 17p12 · 11|11 B3
Bgee: tibialis anterior muscle · thoracic diaphragm · myocardium of left ventricle · deltoid muscle · gastrocnemius muscle
BioGPS: More reference expression data
Chr.: Chromosome 17 (human) · Chromosome 11 (mouse)

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Enzyme
Gene
Cytochrome c oxidase
Mitochondrial respiratory chain Electron transport chain
Catalyzes Catalysis
Electron transfer
Reduced Redox
Cytochrome c
Oxygen
Heteromeric Heteromer
Complex Protein complex
Subunits Protein subunit
Mitochondrial genes Mitochondrial DNA
Nuclear genes Nuclear DNA
Heme A
Farnesyltransferase
Expression Gene expression
Mutation
Substitution Amino acid replacement
Lysine
Asparagine
CMT1A Charcot–Marie–Tooth disease
(Charcot-Marie-Tooth type 1A) Charcot–Marie–Tooth disease classifications
HNPP (hereditary neuropathy with liability to pressure palsies) Hereditary neuropathy with liability to pressure palsy
Deletion Deletion (genetics)

Structure

Chromosome 17
Amino acids
3' untranslated region Three prime untranslated region
Open reading frame
Exons Exon
Transmembrane domains Transmembrane domain
Localized Protein subcellular localization prediction
Mitochondrial inner membrane Inner mitochondrial membrane
Hydrophilic Hydrophile
Loops Omega loop
Constituent Membrane protein

Function

Clinical Significance

Interactions

Interacts Protein-protein interactions
FAM136A

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Nodes62

Edges61

Triples104

Avg. degree1.97

Density0.032258

Components1

How this topic connects Entity context

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COX10

Top relations

Gene ontology · 24

COX10 → aerobic dissimilation, cellular respiration, cytochrome complex, cytochrome complex assembly, cytochrome-c oxidase activity, cytosol, farnesyltranstransferase activity, heme A biosynthetic process, heme biosynthetic process, heme O biosynthetic process, integral component of membrane, membrane, mitochondrial electron transport, cytochrome c to oxygen, mitochondrial fission, mitochondrial inner membrane, mitochondrial membranes, mitochondrion, mitochondrion organization, nucleolus, protoheme IX farnesyltransferase activity

Bgee · 18

COX10 → biceps brachii, deltoid muscle, digastric muscle, extraocular muscle, gastrocnemius muscle, interventricular septum, muscle of thigh, myocardium of left ventricle, myocardium of ventricle, otic vesicle, primary oocyte, secondary oocyte, skeletal muscle tissue, thoracic diaphragm, tibialis anterior muscle, triceps brachii muscle, vastus lateralis muscle, zygote

RNA expression pattern · 18

related to Clinical Significance · 9

COX10 → Charcot-Marie-Tooth, CMT1A, COX, French Canadian, HNPP, In, Leigh, Leigh Syndrome, Mutations

related to Structure · 6

COX10 → II/III, The, The COX10, There, This, VI/VII

related to Function · 4

COX10 → C2, COX, It, The

Band · 2

COX10 → 11|11 B3, 17p12

Chr. · 2

COX10 → Chromosome 11 (mouse), Chromosome 17 (human)

End · 2

COX10 → 14,231,736 bp, 63,970,294 bp

related to External links · 2

COX10 → Human COX10, UCSC Genome Browser

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene mitochondrial bp human farnesyltransferase chr band heme chromosome 17 cytochrome oxidase protein complex cox assembly location component electron function

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
COX10	2.5.1.141	↗	1.00	infobox
COX10	Aliases	COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor, cytochrome c oxidase assembly factor heme A:farnesyltransferase MC4DN3	1.00	infobox
COX10	Band	17p12	1.00	infobox
COX10	Band	11\|11 B3	1.00	infobox
COX10	Bgee	tibialis anterior muscle	1.00	infobox
COX10	Bgee	thoracic diaphragm	1.00	infobox
COX10	Bgee	myocardium of left ventricle	1.00	infobox
COX10	Bgee	deltoid muscle	1.00	infobox
COX10	Bgee	gastrocnemius muscle	1.00	infobox
COX10	Bgee	triceps brachii muscle	1.00	infobox
COX10	Bgee	vastus lateralis muscle	1.00	infobox
COX10	Bgee	muscle of thigh	1.00	infobox
COX10	Bgee	secondary oocyte	1.00	infobox
COX10	Bgee	biceps brachii	1.00	infobox
COX10	Bgee	zygote	1.00	infobox
COX10	Bgee	interventricular septum	1.00	infobox
COX10	Bgee	otic vesicle	1.00	infobox
COX10	Bgee	primary oocyte	1.00	infobox
COX10	Bgee	myocardium of ventricle	1.00	infobox
COX10	Bgee	skeletal muscle tissue	1.00	infobox
COX10	Bgee	extraocular muscle	1.00	infobox
COX10	Bgee	digastric muscle	1.00	infobox
COX10	BioGPS	More reference expression data	1.00	infobox
COX10	Chr.	Chromosome 17 (human)	1.00	infobox
COX10	Chr.	Chromosome 11 (mouse)	1.00	infobox
COX10	Databases	NCBI: entry; OMA: entry	1.00	infobox
COX10	End	14,231,736 bp	1.00	infobox
COX10	End	63,970,294 bp	1.00	infobox
COX10	Ensembl	ENSG00000006695	1.00	infobox
COX10	Entrez	1352	1.00	infobox

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