SCO2

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SCO2 topic overview

The analysis highlights Clinical significance, Function and Structure as prominent areas in the source structure around SCO2.

Related topics: 59
Source areas: 5
Connected nodes: 64
Extracted relationships: 119
Concept neighborhoods: 22
Bridge connections: 64

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 26 topics

Overview · 13 topics

Function · 10 topics

Structure · 6 topics

Interactions · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: SCO2, CEMCOX1, MYP6, SCO1L, SCO2 cytochrome c oxidase assembly protein, cytochrome c oxidase assembly protein, PD-ECGF, TP, Gliostatin, TYMP, ECGF1, TdRPase, SCO cytochrome c ox…
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2RLI
Band: 22q13.33 · 15|15 E3
Bgee: right uterine tube · granulocyte · mucosa of transverse colon · monocyte · gingival epithelium
BioGPS: n/a
Chr.: Chromosome 22 (human) · Chromosome 15 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Protein
Gene
Cytochrome c oxidase (COX) Cytochrome c oxidase
Protein complex
Catalyzes Catalysis
Cytochrome c
Molecular oxygen
Proton gradient
Inner mitochondrial membrane
ATP Adenosine triphosphate
Metallochaperone Chaperone (protein)
Cytochrome c oxidase subunit II
Myopia

Structure

Function

Mitochondrial respiratory chain
Biogenesis
Catalytic subunit 1 Cytochrome c oxidase subunit I
Thiol
Disulfide
Oxidoreductase
Cysteines Cystein
SCO1
Oxygen
Protons

Clinical significance

Copper
Hypotonia
Developmental delay Developmental disability
Hypertrophic cardiomyopathy
Lactic acidosis
Gliosis
Basal ganglia
Brainstem
Spinal cord
Refractive Refraction
Retina
Leigh syndrome
Neurodegenerative disorder Neurodegeneration
Lesions Lesion
Central nervous system
Thalamus
Cerebellum
Psychomotor retardation
Ataxia
Vision loss
Eye movement
Seizures
Dysphagia
Phenotypes
Missense mutation
Nonsense mutation

Interactions

COA6
THEM177 THEM177?action=edit&redlink=1
COX20
COX16 COX16?action=edit&redlink=1

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How SCO2 connects Entity context

The extracted context around SCO2 shows recurring relationship patterns in the source. For example, SCO2 → blastocyst, colon, duodenum, embryo, epithelium of bronchus, gingival epithelium, gonad, granulocyte, jejunum, monocyte, morula, mucosa of transverse colon, muscle of thigh, palpebral conjunctiva, periodontal fiber, proximal tubule, right kidney, right lobe of liver, right uterine tube, yolk sac Another extracted example is SCO2 → cell redox homeostasis, cellular copper ion homeostasis, copper ion binding, copper ion transport, eye development, integral component of membrane, integral component of mitochondrial inner membrane, membrane, metal ion binding, mitochondrial cytochrome c oxidase assembly, mitochondrial inner membrane, mitochondrial matrix, mitochondrion, myofibril, protein binding, protein-disulfide reductase activity, respiratory chain complex IV assembly. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Bgee · 20

SCO2 → blastocyst, colon, duodenum, embryo, epithelium of bronchus, gingival epithelium, gonad, granulocyte, jejunum, monocyte, morula, mucosa of transverse colon, muscle of thigh, palpebral conjunctiva, periodontal fiber, proximal tubule, right kidney, right lobe of liver, right uterine tube, yolk sac

RNA expression pattern · 20

Gene ontology · 17

SCO2 → cell redox homeostasis, cellular copper ion homeostasis, copper ion binding, copper ion transport, eye development, integral component of membrane, integral component of mitochondrial inner membrane, membrane, metal ion binding, mitochondrial cytochrome c oxidase assembly, mitochondrial inner membrane, mitochondrial matrix, mitochondrion, myofibril, protein binding, protein-disulfide reductase activity, respiratory chain complex IV assembly

related to Clinical significance · 15

SCO2 → Cardioencephalomyopathy, CEMCOX1, Clinical, COX, E140K, G1541A, Lastly, Leigh, LS, Mutations, Myopia, MYP6, Other, Q53X, SMA

related to Function · 9

SCO2 → Complex IV, COX, Cu, II, In, Mammalian, SCO1, The, The SCO2

related to Interactions · 7

SCO2 → COA6, COX16, COX20, COX20-dependent, In, SCO1, THEM177

related to Structure · 6

SCO2 → Complex IV, COX, Mammalian, N-terminal, The, The SCO2

Band · 2

SCO2 → 15|15 E3, 22q13.33

Chr. · 2

SCO2 → Chromosome 15 (mouse), Chromosome 22 (human)

End · 2

SCO2 → 50,526,461 bp, 89,258,049 bp

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cytochrome protein oxidase gene human cox assembly complex bp mitochondrial iv chr band subunit chromosome 22 ii encoded location copper

SCO2 relationships Subject–Predicate–Object triples

TTTA extracted 119 structured relationships around SCO2. Examples in this analysis include SCO2 → Aliases → SCO2, CEMCOX1, MYP6, SCO1L, SCO2 cytochrome c oxidase assembly protein, cytochrome c oxidase assembly protein, PD-ECGF, TP, Gliostatin, TYMP, ECGF1, TdRPase, SCO cytochrome c ox… and SCO2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2RLI. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
SCO2	Aliases	SCO2, CEMCOX1, MYP6, SCO1L, SCO2 cytochrome c oxidase assembly protein, cytochrome c oxidase assembly protein, PD-ECGF, TP, Gliostatin, TYMP, ECGF1, TdRPase, SCO cytochrome c ox…	1.00	infobox
SCO2	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2RLI	1.00	infobox
SCO2	Band	22q13.33	1.00	infobox
SCO2	Band	15\|15 E3	1.00	infobox
SCO2	Bgee	right uterine tube	1.00	infobox
SCO2	Bgee	granulocyte	1.00	infobox
SCO2	Bgee	mucosa of transverse colon	1.00	infobox
SCO2	Bgee	monocyte	1.00	infobox
SCO2	Bgee	gingival epithelium	1.00	infobox
SCO2	Bgee	gonad	1.00	infobox
SCO2	Bgee	palpebral conjunctiva	1.00	infobox
SCO2	Bgee	periodontal fiber	1.00	infobox
SCO2	Bgee	right lobe of liver	1.00	infobox
SCO2	Bgee	epithelium of bronchus	1.00	infobox
SCO2	Bgee	yolk sac	1.00	infobox
SCO2	Bgee	blastocyst	1.00	infobox
SCO2	Bgee	embryo	1.00	infobox
SCO2	Bgee	duodenum	1.00	infobox
SCO2	Bgee	colon	1.00	infobox
SCO2	Bgee	proximal tubule	1.00	infobox
SCO2	Bgee	right kidney	1.00	infobox
SCO2	Bgee	muscle of thigh	1.00	infobox
SCO2	Bgee	jejunum	1.00	infobox
SCO2	Bgee	morula	1.00	infobox
SCO2	BioGPS	n/a	1.00	infobox
SCO2	Chr.	Chromosome 22 (human)	1.00	infobox
SCO2	Chr.	Chromosome 15 (mouse)	1.00	infobox
SCO2	Databases	NCBI: entry; OMA: entry	1.00	infobox
SCO2	End	50,526,461 bp	1.00	infobox
SCO2	End	89,258,049 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around SCO2 bring nearby vocabulary together. In this analysis, examples include Ucsc, Copper and Location. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

protein
- Complex
- Gene
- Sco2
- Iv
- Encoded
- Factors
- Human
- Function
- Cox
- Inner
- Membrane
- Molecular
gene
- Sco2
- Location
- Human
- Protein
- Ucsc
- Chromosome
- Function
- Bp
- Chr
- Mitochondrial
- Mouse
- Oxidase
cytochrome c oxidase (cox)
- Oxidase
- Subunit
- Sco2
- Complex
- Iv
- Ii
- Assembly
- Protein
- Mitochondrial
- Copper
- Function
- Cox
protein complex
- Iv
- Factors
- Cox
- Complex
- Protein
- Cytochrome
- Gene
- Oxidase
- Sco2
- Mitochondrial
- Encoded
- Human
cytochrome c
- Oxidase
- Iv
- Sco2
- Subunit
- Assembly
- Complex
- Protein
- Ii
- Mitochondrial
- Cox
- Copper
- Function
inner mitochondrial membrane
- Membrane
- Molecular
- Inner
- Mitochondrial
- Oxygen
- Protein
- Catalyzes
- Iv
- Complex
- Sco2
- Function
- Gene
cytochrome c oxidase subunit ii
- Oxidase
- Subunit
- Sco2
- Iv
- Metallochaperone
- Ii
- Assembly
- Complex
- Protein
- Synthesis
- Mitochondrial
- Copper
mitochondrial respiratory chain
- Inner
- Membrane
- Molecular
- Protein
- Catalyzes
- Iv
- Complex
- Oxygen
- Sco2
- Function
- Gene
- Oxidase

Connections between topic areas Semantic bridges

For SCO2, one of the stronger structural bridges in this analysis connects SCO2 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

SCO2 — Clinical significance · splits 38 ⟂ 27

SCO2 — Overview · splits 51 ⟂ 14

SCO2 — Function · splits 54 ⟂ 11

SCO2 — Structure · splits 58 ⟂ 7

SCO2 — Interactions · splits 60 ⟂ 5

Map overview Semantic statistics

SCO2

Nodes65

Edges64

Triples119

Avg. degree1.97

Density0.030769

Components1

Source & methodology

TTTA analyzes the structure around SCO2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Function & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — SCO2 · EN edition · Analysis: TopicsToTalkAbout