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COX15: Art, Clinical significance & Function

Cytochrome c oxidase assembly protein COX15 homolog (COX15), also known as heme A synthase, is a protein that in humans is encoded by the COX15 gene. This protein localizes to the inner mitochondrial membrane and involved in heme A biosynthesis. COX15 is also part of a three-component mono-oxygenase (ferredoxin, ferredoxin reductase, and COX15) that…

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COX15 topic overview

The analysis highlights Art, Clinical significance and Function as prominent areas in the source structure around COX15.

Related topics
41
Source areas
5
Connected nodes
46
Extracted relationships
109
Concept neighborhoods
19
Bridge connections
46

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 13 topics
Overview · 12 topics
Function · 7 topics
Structure · 6 topics
Interactions · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

1.17.99.9
Aliases
COX15, CEMCOX2, COX15 cytochrome c oxidase assembly homolog, cytochrome c oxidase assembly homolog, cytochrome c oxidase assembly homolog COX15
Band
10q24.2 · 19|19 C3
Bgee
caput epididymis · corpus epididymis · tail of epididymis · right uterine tube · Skeletal muscle tissue of rectus abdominis
BioGPS
More reference expression data
Chr.
Chromosome 10 (human) · Chromosome 19 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How COX15 connects Entity context

The extracted context around COX15 shows recurring relationship patterns in the source. For example, COX15 → cellular respiration, cytochrome complex, cytochrome-c oxidase activity, heme A biosynthetic process, heme binding, heme biosynthetic process, integral component of membrane, membrane, mitochondrial electron transport, cytochrome c to oxygen, mitochondrial inner membrane, mitochondrial membranes, mitochondrial respirasome, mitochondrion, molecular adaptor activity, nucleus, oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor, oxidoreductase activity, acting on the CH-CH group of donors, protein binding, proton transmembrane transport, respiratory chain complex IV assembly Another extracted example is COX15 → atrium, barrel cortex, body of tongue, caput epididymis, ciliary body, corpus epididymis, epithelium of small intestine, epithelium of stomach, external carotid artery, internal carotid artery, left adrenal gland, migratory enteric neural crest cell, renal medulla, right adrenal cortex, right adrenal gland, right uterine tube, seminal vesicula, Skeletal muscle tissue of rectus abdominis, soleus muscle, tail of epididymis. Use these groups to spot repeated connection types before inspecting the individual relationships.

COX15

Top relations

Gene ontology · 21
COX15 → cellular respiration, cytochrome complex, cytochrome-c oxidase activity, heme A biosynthetic process, heme binding, heme biosynthetic process, integral component of membrane, membrane, mitochondrial electron transport, cytochrome c to oxygen, mitochondrial inner membrane, mitochondrial membranes, mitochondrial respirasome, mitochondrion, molecular adaptor activity, nucleus, oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor, oxidoreductase activity, acting on the CH-CH group of donors, protein binding, proton transmembrane transport, respiratory chain complex IV assembly
Bgee · 20
COX15 → atrium, barrel cortex, body of tongue, caput epididymis, ciliary body, corpus epididymis, epithelium of small intestine, epithelium of stomach, external carotid artery, internal carotid artery, left adrenal gland, migratory enteric neural crest cell, renal medulla, right adrenal cortex, right adrenal gland, right uterine tube, seminal vesicula, Skeletal muscle tissue of rectus abdominis, soleus muscle, tail of epididymis
RNA expression pattern · 20
COX15 → atrium, barrel cortex, body of tongue, caput epididymis, ciliary body, corpus epididymis, epithelium of small intestine, epithelium of stomach, external carotid artery, internal carotid artery, left adrenal gland, migratory enteric neural crest cell, renal medulla, right adrenal cortex, right adrenal gland, right uterine tube, seminal vesicula, Skeletal muscle tissue of rectus abdominis, soleus muscle, tail of epididymis
related to Interactions · 6
COX15 → C-terminal, COA, COX, COX1, Huntingtin-associated, Shy1
related to Clinical significance · 5
COX15 → Alzheimer's, COX, Leigh, Signs, Therefore
related to Function · 5
COX15 → C-8, COX, In, IV, Similar
related to Gene · 5
COX15 → But, C-terminal, The COX15, Two, UTR
related to Protein · 3
COX15 → Both COX15, Four, The COX15
Band · 2
COX15 → 10q24.2, 19|19 C3
Chr. · 2
COX15 → Chromosome 10 (human), Chromosome 19 (mouse)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene heme protein cox bp human assembly cytochrome chr band oxidase chromosome location also 10 mitochondrial group activity membrane external

COX15 relationships Subject–Predicate–Object triples

TTTA extracted 109 structured relationships around COX15. Examples in this analysis include COX15 → 1.17.99.9 → ↗ and COX15 → Aliases → COX15, CEMCOX2, COX15 cytochrome c oxidase assembly homolog, cytochrome c oxidase assembly homolog, cytochrome c oxidase assembly homolog COX15. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
COX151.17.99.91.00infobox
COX15AliasesCOX15, CEMCOX2, COX15 cytochrome c oxidase assembly homolog, cytochrome c oxidase assembly homolog, cytochrome c oxidase assembly homolog COX151.00infobox
COX15Band10q24.21.00infobox
COX15Band19|19 C31.00infobox
COX15Bgeecaput epididymis1.00infobox
COX15Bgeecorpus epididymis1.00infobox
COX15Bgeetail of epididymis1.00infobox
COX15Bgeeright uterine tube1.00infobox
COX15BgeeSkeletal muscle tissue of rectus abdominis1.00infobox
COX15Bgeeright adrenal gland1.00infobox
COX15Bgeeright adrenal cortex1.00infobox
COX15Bgeeleft adrenal gland1.00infobox
COX15Bgeerenal medulla1.00infobox
COX15Bgeebody of tongue1.00infobox
COX15Bgeeepithelium of small intestine1.00infobox
COX15Bgeeexternal carotid artery1.00infobox
COX15Bgeeinternal carotid artery1.00infobox
COX15Bgeeseminal vesicula1.00infobox
COX15Bgeeatrium1.00infobox
COX15Bgeeepithelium of stomach1.00infobox
COX15Bgeesoleus muscle1.00infobox
COX15Bgeemigratory enteric neural crest cell1.00infobox
COX15Bgeebarrel cortex1.00infobox
COX15Bgeeciliary body1.00infobox
COX15BioGPSMore reference expression data1.00infobox
COX15Chr.Chromosome 10 (human)1.00infobox
COX15Chr.Chromosome 19 (mouse)1.00infobox
COX15DatabasesNCBI: entry; OMA: entry1.00infobox
COX15End99,732,100 bp1.00infobox
COX15End43,741,439 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around COX15 bring nearby vocabulary together. In this analysis, examples include Heme, Protein and Cytochrome. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • COX15
    • Heme
    • Protein
    • Cytochrome
    • Oxidase
    • Activity
    • Also
    • Group
    • Gene
    • Cox
    • Location
    • Mitochondrial
    • Human
  • cox15
    • Heme
    • Protein
    • Cytochrome
    • Oxidase
    • Activity
    • Also
    • Group
    • Gene
    • Cox
    • Location
    • Mitochondrial
    • Human
  • gene
    • Location
    • Human
    • Chromosome
    • Bp
    • Chr
    • Oxidase
    • External
    • Function
    • Homolog
    • Mouse
    • Protein
    • Activity
  • heme a
    • Cox
    • Protein
    • Group
    • Mitochondrial
    • Oxidase
    • Biosynthesis
    • Chain
    • Electron
    • Inner
    • Membrane
    • Respiratory
    • Transport
  • methyl group
    • Hydroxylation
    • Group
    • Methyl
    • Mitochondrial
    • Oxidase
    • Heme
    • Also
    • External
    • Function
    • Mouse
    • Chain
    • Electron
  • cytochrome
    • Oxidase
    • Assembly
    • External
    • Function
    • Homolog
    • Gene
    • Protein
    • Activity
    • Chromosome
    • Group
    • Location
    • Mitochondrial
  • heme o
    • Cox
    • Protein
    • Group
    • Mitochondrial
    • Oxidase
    • Biosynthesis
    • Chain
    • Electron
    • Inner
    • Membrane
    • Respiratory
    • Transport
  • electron transport
    • Electron
    • Transport
    • Chain
    • Deficiency
    • Cox
    • External
    • Function
    • Humans
    • Mouse
    • Functional
    • Inner
    • Membrane

Connections between topic areas Semantic bridges

For COX15, one of the stronger structural bridges in this analysis connects COX15 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
COX15Clinical significance · splits 33 ⟂ 14
COX15Overview · splits 34 ⟂ 13
COX15Function · splits 39 ⟂ 8
COX15Structure · splits 40 ⟂ 7
COX15Interactions · splits 43 ⟂ 4

Map overview Semantic statistics

COX15

Nodes47
Edges46
Triples109
Avg. degree1.96
Density0.042553
Components1

Source & methodology

TTTA analyzes the structure around COX15 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Clinical significance & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — COX15 · EN edition · Analysis: TopicsToTalkAbout

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