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Membrane cofactor protein: Clinical significance, Function & Interactions

Membrane cofactor protein (MCP), CD46 complement regulatory protein also known as CD46 (cluster of differentiation 46) is a protein which in humans is encoded by the CD46 gene. CD46 is an inhibitory complement receptor.

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Membrane cofactor protein topic overview

The analysis highlights Clinical significance, Function and Interactions as prominent areas in the source structure around Membrane cofactor protein.

Related topics
21
Source areas
5
Connected nodes
26
Extracted relationships
120
Concept neighborhoods
12
Bridge connections
26

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 7 topics
Function · 5 topics
Interactions · 4 topics
Overview · 4 topics
Gene · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CD46, AHUS2, MCP, MIC10, TLX, TRA2.10, CD46 molecule
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3O8E, 1CKL, 2O39, 3INB, 3L89, 5FO8
Band
1q32.2 · 1 H6|1 98.41 cM
Bgee
palpebral conjunctiva · seminal vesicula · bronchial epithelial cell · jejunal mucosa · germinal epithelium
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 1 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Gene

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Membrane cofactor protein connects Entity context

The extracted context around Membrane cofactor protein shows recurring relationship patterns in the source. For example, Membrane cofactor protein → acrosomal vesicle, adaptive immune response, basolateral plasma membrane, cadherin binding, cell surface, complement activation, classical pathway, complement binding, cytoplasm, cytoplasmic vesicle, endopeptidase activity, enzyme inhibitor activity, extracellular exosome, focal adhesion, Golgi apparatus, immune system process, innate immune response, inner acrosomal membrane, integral component of membrane, integral component of plasma membrane, interleukin-10 production Another extracted example is Membrane cofactor protein → body of pancreas, bronchial epithelial cell, embryo, germinal epithelium, granulocyte, intestinal villus, jejunal mucosa, lumbar subsegment of spinal cord, muscle of thigh, palpebral conjunctiva, parotid gland, placenta, primary visual cortex, right lung, right uterine tube, seminal vesicula, seminiferous tubule, spermatid, vastus lateralis muscle, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

Membrane cofactor protein

Top relations

Gene ontology · 42
Membrane cofactor protein → acrosomal vesicle, adaptive immune response, basolateral plasma membrane, cadherin binding, cell surface, complement activation, classical pathway, complement binding, cytoplasm, cytoplasmic vesicle, endopeptidase activity, enzyme inhibitor activity, extracellular exosome, focal adhesion, Golgi apparatus, immune system process, innate immune response, inner acrosomal membrane, integral component of membrane, integral component of plasma membrane, interleukin-10 production
Bgee · 20
Membrane cofactor protein → body of pancreas, bronchial epithelial cell, embryo, germinal epithelium, granulocyte, intestinal villus, jejunal mucosa, lumbar subsegment of spinal cord, muscle of thigh, palpebral conjunctiva, parotid gland, placenta, primary visual cortex, right lung, right uterine tube, seminal vesicula, seminiferous tubule, spermatid, vastus lateralis muscle, ventricular zone
RNA expression pattern · 20
Membrane cofactor protein → body of pancreas, bronchial epithelial cell, embryo, germinal epithelium, granulocyte, intestinal villus, jejunal mucosa, lumbar subsegment of spinal cord, muscle of thigh, palpebral conjunctiva, parotid gland, placenta, primary visual cortex, right lung, right uterine tube, seminal vesicula, seminiferous tubule, spermatid, vastus lateralis muscle, ventricular zone
related to External links · 15
Membrane cofactor protein → Atypical Hemolytic-Uremic SyndromeCD46, Atypical Hemolytic-Uremic SyndromeOMIM, CD46, GeneReviews/NCBI/NIH/UW, Human CD46, Human Membrane, Medicine Medical Subject Headings, MeSH, National Library, Overview, P15529, PDB, PDBe-KB, UCSC Genome Browser, UniProt
Band · 2
Membrane cofactor protein → 1 H6|1 98.41 cM, 1q32.2
Chr. · 2
Membrane cofactor protein → Chromosome 1 (human), Chromosome 1 (mouse)
End · 2
Membrane cofactor protein → 194,774,557 bp, 207,795,513 bp
Aliases · 1
Membrane cofactor protein → CD46, AHUS2, MCP, MIC10, TLX, TRA2.10, CD46 molecule
Available structures · 1
Membrane cofactor protein → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3O8E, 1CKL, 2O39, 3INB, 3L89, 5FO8
BioGPS · 1
Membrane cofactor protein → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cd46 gene human protein bp complement chr band chromosome encoded membrane receptor location binding regulatory medulloblastoma hhv-6 cofactor entry measles

Membrane cofactor protein relationships Subject–Predicate–Object triples

TTTA extracted 120 structured relationships around Membrane cofactor protein. Examples in this analysis include Membrane cofactor protein → Aliases → CD46, AHUS2, MCP, MIC10, TLX, TRA2.10, CD46 molecule and Membrane cofactor protein → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3O8E, 1CKL, 2O39, 3INB, 3L89, 5FO8. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Membrane cofactor proteinAliasesCD46, AHUS2, MCP, MIC10, TLX, TRA2.10, CD46 molecule1.00infobox
Membrane cofactor proteinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3O8E, 1CKL, 2O39, 3INB, 3L89, 5FO81.00infobox
Membrane cofactor proteinBand1q32.21.00infobox
Membrane cofactor proteinBand1 H6|1 98.41 cM1.00infobox
Membrane cofactor proteinBgeepalpebral conjunctiva1.00infobox
Membrane cofactor proteinBgeeseminal vesicula1.00infobox
Membrane cofactor proteinBgeebronchial epithelial cell1.00infobox
Membrane cofactor proteinBgeejejunal mucosa1.00infobox
Membrane cofactor proteinBgeegerminal epithelium1.00infobox
Membrane cofactor proteinBgeeparotid gland1.00infobox
Membrane cofactor proteinBgeeplacenta1.00infobox
Membrane cofactor proteinBgeeright uterine tube1.00infobox
Membrane cofactor proteinBgeeright lung1.00infobox
Membrane cofactor proteinBgeebody of pancreas1.00infobox
Membrane cofactor proteinBgeeseminiferous tubule1.00infobox
Membrane cofactor proteinBgeespermatid1.00infobox
Membrane cofactor proteinBgeegranulocyte1.00infobox
Membrane cofactor proteinBgeevastus lateralis muscle1.00infobox
Membrane cofactor proteinBgeeintestinal villus1.00infobox
Membrane cofactor proteinBgeeprimary visual cortex1.00infobox
Membrane cofactor proteinBgeelumbar subsegment of spinal cord1.00infobox
Membrane cofactor proteinBgeemuscle of thigh1.00infobox
Membrane cofactor proteinBgeeventricular zone1.00infobox
Membrane cofactor proteinBgeeembryo1.00infobox
Membrane cofactor proteinBioGPSMore reference expression data1.00infobox
Membrane cofactor proteinChr.Chromosome 1 (human)1.00infobox
Membrane cofactor proteinChr.Chromosome 1 (mouse)1.00infobox
Membrane cofactor proteinDatabasesNCBI: entry; OMA: entry1.00infobox
Membrane cofactor proteinEnd207,795,513 bp1.00infobox
Membrane cofactor proteinEnd194,774,557 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Membrane cofactor protein bring nearby vocabulary together. In this analysis, examples include Regulatory, Cluster and Complement. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Membrane cofactor protein
    • Regulatory
    • Cluster
    • Complement
    • Differentiation
    • P15529
    • Protein
    • System
    • Uniprot
    • Membrane
    • Gene
    • Encoded
    • Binding
  • membrane cofactor protein
    • Regulatory
    • Cluster
    • Complement
    • Differentiation
    • P15529
    • Protein
    • System
    • Uniprot
    • Membrane
    • Encoded
    • Gene
    • Mcp
  • cluster of differentiation
    • Differentiation
    • Regulatory
    • Membrane
    • Complement
    • End
    • Function
    • Mcp
    • Mouse
    • P15529
    • Search
    • System
    • Uniprot
  • gene
    • Location
    • Regulatory
    • Chromosome
    • Human
    • Membrane
    • Protein
    • Bp
    • Chr
    • End
    • Function
    • Mcp
    • Mouse
  • complement receptor
    • Regulatory
    • Membrane
    • Protein
    • Encoded
    • Cluster
    • Differentiation
    • System
    • Virus
    • Hhv-6
    • Gene
    • Receptor
    • P15529
  • chromosome 1q
    • Bp
    • Band
    • Location
    • End
    • Function
    • Human
    • Mouse
    • Search
    • Gene
    • External
    • Cluster
    • Differentiation
  • complement system
    • Regulatory
    • Membrane
    • Protein
    • Encoded
    • Cluster
    • Differentiation
    • System
    • P15529
    • Search
    • Uniprot
    • Gene
    • Receptor
  • measles virus
    • Measles
    • Medulloblastoma
    • Virus
    • Receptor
    • Cluster
    • Differentiation
    • End
    • Function
    • Mouse
    • P15529
    • Pdb
    • Search

Connections between topic areas Semantic bridges

For Membrane cofactor protein, one of the stronger structural bridges in this analysis connects Membrane cofactor protein with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Membrane cofactor proteinClinical significance · splits 19 ⟂ 8
Membrane cofactor proteinFunction · splits 21 ⟂ 6
Membrane cofactor proteinOverview · splits 22 ⟂ 5
Membrane cofactor proteinInteractions · splits 22 ⟂ 5

Map overview Semantic statistics

Membrane cofactor protein

Nodes27
Edges26
Triples120
Avg. degree1.93
Density0.074074
Components1

Source & methodology

TTTA analyzes the structure around Membrane cofactor protein to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Function & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Membrane cofactor protein · EN edition · Analysis: TopicsToTalkAbout

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