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Factor H

Factor H (FH) is a soluble glycoprotein and a member of the regulators of complement activation (RCA) family. It functions as a complement control protein and plays a critical role in regulating the complement system, particularly the alternative pathway. Factor H is a large molecule with a molecular weight of approximately 155 kilodaltons and circulates…

Art, Clinical significance & Function

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Aliases
CFH, AHUS1, AMBP1, ARMD4, ARMS1, CFHL3, FH, FHL1, HF, HF1, HF2, HUS, complement factor H
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4ONT, 1HAQ, 1HCC, 1HFH, 1HFI, 2BZM, 2G7I, 2IC4, 2JGW, 2JGX, 2KMS, 2QFG, 2QFH, 2RLP, 2RLQ, 2UWN, 2V8E, 2W80,…
Band
1q31.3 · 1 61.62 cM|1 F
Bgee
urethra · Achilles tendon · right coronary artery · right lobe of liver · saphenous vein
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 1 (mouse)

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Overview

Structure

Function

Clinical significance

Interactions

Recombinant production

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Map overview Semantic statistics

Factor H

Nodes59
Edges58
Triples176
Avg. degree1.97
Density0.033898
Components1

How this topic connects Entity context

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Factor H

Top relations

related to Age-related macular degeneration · 30
Factor H → Age Related Macular Degeneration, Although, AMD, AMD-like, Blood-retinal, Bruch's, C2/factor, C3, CCP, CCPs, CFH, Clark, Europeans, FH, FHL-1, Further, H-like, H-related, Homozygous, However
Bgee · 20
Factor H → Achilles tendon, aorta, aortic valve, ascending aorta, body of femur, gallbladder, left coronary artery, left lobe of liver, parietal pleura, pineal gland, popliteal artery, right coronary artery, right lobe of liver, saphenous vein, synovial joint, tunica adventitia of aorta, tunica media of zone of aorta, urethra, uterus, vas deferens
RNA expression pattern · 20
Factor H → Achilles tendon, aorta, aortic valve, ascending aorta, body of femur, gallbladder, left coronary artery, left lobe of liver, parietal pleura, pineal gland, popliteal artery, right coronary artery, right lobe of liver, saphenous vein, synovial joint, tunica adventitia of aorta, tunica media of zone of aorta, urethra, uterus, vas deferens
related to Recruitment by pathogens · 19
Factor H → Aspergillus, Borrelia, Candida, CFH, CRASP-1, CRASP-2, CRASP-3, CRASP-4, CRASP-5, Each CRASP, Francisella, Given, Haemophilus, It, Neisseria, Pathogens, Streptococcus, The Gram-negative, This
Gene ontology · 14
Factor H → blood microparticle, complement activation, complement activation, alternative pathway, extracellular exosome, extracellular region, extracellular space, heparan sulfate proteoglycan binding, heparin binding, immune system process, innate immune response, protein binding, regulation of complement activation, regulation of complement-dependent cytotoxicity, viral process
related to Structure · 14
Factor H → Although, C3b, C3d, CCP, CCPs, Each, GAG, GAGs, Information, N-terminus, Short Consensus Repeats, The, The CCP, To
related to Atypical hemolytic uremic syndrome · 11
Factor H → AMD, C-terminus, C3, CCP, CCPs, Escherichia, Hemolytic, HUS, In, It, N-terminus
related to Function · 11
Factor H → C3-convertase, C3b, C3bBb, Factor, Factor I-mediated, FH, However, It, Neisseria, The, This
related to Clinical significance · 7
Factor H → CFH, Due, It, Moreover, Overactive, SNPs, Underactive
related to Recombinant production · 5
Factor H → Biologically, Factor, Large, Pichia, Ralf Reski

Important terminology Word statistics

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Important terminology

factor complement human protein cfh amd pathogens bp fh alternative pathway activation gene chr band ccp cells associated system 20

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Factor HAliasesCFH, AHUS1, AMBP1, ARMD4, ARMS1, CFHL3, FH, FHL1, HF, HF1, HF2, HUS, complement factor H1.00infobox
Factor HAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4ONT, 1HAQ, 1HCC, 1HFH, 1HFI, 2BZM, 2G7I, 2IC4, 2JGW, 2JGX, 2KMS, 2QFG, 2QFH, 2RLP, 2RLQ, 2UWN, 2V8E, 2W80,…1.00infobox
Factor HBand1q31.31.00infobox
Factor HBand1 61.62 cM|1 F1.00infobox
Factor HBgeeurethra1.00infobox
Factor HBgeeAchilles tendon1.00infobox
Factor HBgeeright coronary artery1.00infobox
Factor HBgeeright lobe of liver1.00infobox
Factor HBgeesaphenous vein1.00infobox
Factor HBgeesynovial joint1.00infobox
Factor HBgeeleft coronary artery1.00infobox
Factor HBgeeparietal pleura1.00infobox
Factor HBgeepopliteal artery1.00infobox
Factor HBgeegallbladder1.00infobox
Factor HBgeebody of femur1.00infobox
Factor HBgeeaortic valve1.00infobox
Factor HBgeeaorta1.00infobox
Factor HBgeevas deferens1.00infobox
Factor HBgeetunica media of zone of aorta1.00infobox
Factor HBgeeleft lobe of liver1.00infobox
Factor HBgeetunica adventitia of aorta1.00infobox
Factor HBgeeascending aorta1.00infobox
Factor HBgeepineal gland1.00infobox
Factor HBgeeuterus1.00infobox
Factor HBioGPSMore reference expression data1.00infobox
Factor HChr.Chromosome 1 (human)1.00infobox
Factor HChr.Chromosome 1 (mouse)1.00infobox
Factor HDatabasesNCBI: entry; OMA: entry1.00infobox
Factor HEnd196,752,476 bp1.00infobox
Factor HEnd140,111,502 bp1.00infobox

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