Factor H

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Factor H topic overview

The analysis highlights Art, Clinical significance and Function as prominent areas in the source structure around Factor H.

Related topics: 52
Source areas: 6
Connected nodes: 58
Extracted relationships: 176
Concept neighborhoods: 13
Bridge connections: 58

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 24 topics

Function · 7 topics

Overview · 7 topics

Recombinant production · 6 topics

Structure · 6 topics

Interactions · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: CFH, AHUS1, AMBP1, ARMD4, ARMS1, CFHL3, FH, FHL1, HF, HF1, HF2, HUS, complement factor H
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4ONT, 1HAQ, 1HCC, 1HFH, 1HFI, 2BZM, 2G7I, 2IC4, 2JGW, 2JGX, 2KMS, 2QFG, 2QFH, 2RLP, 2RLQ, 2UWN, 2V8E, 2W80,…
Band: 1q31.3 · 1 61.62 cM|1 F
Bgee: urethra · Achilles tendon · right coronary artery · right lobe of liver · saphenous vein
BioGPS: More reference expression data
Chr.: Chromosome 1 (human) · Chromosome 1 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Interactions

Interact Protein-protein interaction
Complement component 3

Recombinant production

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Factor H connects Entity context

The extracted context around Factor H shows recurring relationship patterns in the source. For example, Factor H → Age Related Macular Degeneration, Although, AMD, AMD-like, Blood-retinal, Bruch's, C2/factor, C3, CCP, CCPs, CFH, Clark, Europeans, FH, FHL-1, Further, H-like, H-related, Homozygous, However Another extracted example is Factor H → Achilles tendon, aorta, aortic valve, ascending aorta, body of femur, gallbladder, left coronary artery, left lobe of liver, parietal pleura, pineal gland, popliteal artery, right coronary artery, right lobe of liver, saphenous vein, synovial joint, tunica adventitia of aorta, tunica media of zone of aorta, urethra, uterus, vas deferens. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

related to Age-related macular degeneration · 30

Factor H → Age Related Macular Degeneration, Although, AMD, AMD-like, Blood-retinal, Bruch's, C2/factor, C3, CCP, CCPs, CFH, Clark, Europeans, FH, FHL-1, Further, H-like, H-related, Homozygous, However

Bgee · 20

Factor H → Achilles tendon, aorta, aortic valve, ascending aorta, body of femur, gallbladder, left coronary artery, left lobe of liver, parietal pleura, pineal gland, popliteal artery, right coronary artery, right lobe of liver, saphenous vein, synovial joint, tunica adventitia of aorta, tunica media of zone of aorta, urethra, uterus, vas deferens

RNA expression pattern · 20

related to Recruitment by pathogens · 19

Factor H → Aspergillus, Borrelia, Candida, CFH, CRASP-1, CRASP-2, CRASP-3, CRASP-4, CRASP-5, Each CRASP, Francisella, Given, Haemophilus, It, Neisseria, Pathogens, Streptococcus, The Gram-negative, This

Gene ontology · 14

Factor H → blood microparticle, complement activation, complement activation, alternative pathway, extracellular exosome, extracellular region, extracellular space, heparan sulfate proteoglycan binding, heparin binding, immune system process, innate immune response, protein binding, regulation of complement activation, regulation of complement-dependent cytotoxicity, viral process

related to Structure · 14

Factor H → Although, C3b, C3d, CCP, CCPs, Each, GAG, GAGs, Information, N-terminus, Short Consensus Repeats, The, The CCP, To

related to Atypical hemolytic uremic syndrome · 11

Factor H → AMD, C-terminus, C3, CCP, CCPs, Escherichia, Hemolytic, HUS, In, It, N-terminus

related to Function · 11

Factor H → C3-convertase, C3b, C3bBb, Factor, Factor I-mediated, FH, However, It, Neisseria, The, This

related to Clinical significance · 7

Factor H → CFH, Due, It, Moreover, Overactive, SNPs, Underactive

related to Recombinant production · 5

Factor H → Biologically, Factor, Large, Pichia, Ralf Reski

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

factor complement human protein cfh amd pathogens bp fh alternative pathway activation gene chr band ccp cells associated system 20

Factor H relationships Subject–Predicate–Object triples

TTTA extracted 176 structured relationships around Factor H. Examples in this analysis include Factor H → Aliases → CFH, AHUS1, AMBP1, ARMD4, ARMS1, CFHL3, FH, FHL1, HF, HF1, HF2, HUS, complement factor H and Factor H → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4ONT, 1HAQ, 1HCC, 1HFH, 1HFI, 2BZM, 2G7I, 2IC4, 2JGW, 2JGX, 2KMS, 2QFG, 2QFH, 2RLP, 2RLQ, 2UWN, 2V8E, 2W80,…. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Factor H	Aliases	CFH, AHUS1, AMBP1, ARMD4, ARMS1, CFHL3, FH, FHL1, HF, HF1, HF2, HUS, complement factor H	1.00	infobox
Factor H	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4ONT, 1HAQ, 1HCC, 1HFH, 1HFI, 2BZM, 2G7I, 2IC4, 2JGW, 2JGX, 2KMS, 2QFG, 2QFH, 2RLP, 2RLQ, 2UWN, 2V8E, 2W80,…	1.00	infobox
Factor H	Band	1q31.3	1.00	infobox
Factor H	Band	1 61.62 cM\|1 F	1.00	infobox
Factor H	Bgee	urethra	1.00	infobox
Factor H	Bgee	Achilles tendon	1.00	infobox
Factor H	Bgee	right coronary artery	1.00	infobox
Factor H	Bgee	right lobe of liver	1.00	infobox
Factor H	Bgee	saphenous vein	1.00	infobox
Factor H	Bgee	synovial joint	1.00	infobox
Factor H	Bgee	left coronary artery	1.00	infobox
Factor H	Bgee	parietal pleura	1.00	infobox
Factor H	Bgee	popliteal artery	1.00	infobox
Factor H	Bgee	gallbladder	1.00	infobox
Factor H	Bgee	body of femur	1.00	infobox
Factor H	Bgee	aortic valve	1.00	infobox
Factor H	Bgee	aorta	1.00	infobox
Factor H	Bgee	vas deferens	1.00	infobox
Factor H	Bgee	tunica media of zone of aorta	1.00	infobox
Factor H	Bgee	left lobe of liver	1.00	infobox
Factor H	Bgee	tunica adventitia of aorta	1.00	infobox
Factor H	Bgee	ascending aorta	1.00	infobox
Factor H	Bgee	pineal gland	1.00	infobox
Factor H	Bgee	uterus	1.00	infobox
Factor H	BioGPS	More reference expression data	1.00	infobox
Factor H	Chr.	Chromosome 1 (human)	1.00	infobox
Factor H	Chr.	Chromosome 1 (mouse)	1.00	infobox
Factor H	Databases	NCBI: entry; OMA: entry	1.00	infobox
Factor H	End	196,752,476 bp	1.00	infobox
Factor H	End	140,111,502 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Factor H bring nearby vocabulary together. In this analysis, examples include Complement, Activity and Shown. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Factor H
- Complement
- Activity
- Shown
- Cells
- Pathogens
- Cfh
- Human
- Protein
- Regulation
- Risk
- Role
- Snp
factor h
- Complement
- Activity
- Shown
- Cells
- Pathogens
- Cfh
- Human
- Protein
- Regulation
- Risk
- Role
- Snp
complement control protein
- Factor
- Ccp
- Modules
- Regulation
- Snp
- Also
- Ccps
- Shown
- Activation
- Alternative
- Pathway
- Role
complement system
- Alternative
- Pathway
- Factor
- Role
- Activation
- Also
- Complement
- Regulation
- System
- Shown
- Cells
- Pathogens
alternative pathway
- Pathway
- System
- Complement
- Regulation
- Role
- Shown
- Cfh
- Protein
- Location
- Band
- Binding
- Chromosome
factor i
- Complement
- Activity
- Shown
- Cells
- Pathogens
- Cfh
- Human
- Protein
- Regulation
- Risk
- Role
- Snp
alternative complement pathway
- Pathway
- System
- Factor
- Activation
- Alternative
- Complement
- Regulation
- Role
- Shown
- Cells
- Pathogens
- Protein
complement component 3
- Factor
- Activation
- Alternative
- Pathway
- Regulation
- Role
- System
- Shown
- Cells
- Pathogens
- Protein
- Also

Connections between topic areas Semantic bridges

For Factor H, one of the stronger structural bridges in this analysis connects Factor H with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Factor H — Clinical significance · splits 34 ⟂ 25

Factor H — Overview · splits 51 ⟂ 8

Factor H — Function · splits 51 ⟂ 8

Factor H — Structure · splits 52 ⟂ 7

Factor H — Recombinant production · splits 52 ⟂ 7

Factor H — Interactions · splits 56 ⟂ 3

Map overview Semantic statistics

Factor H

Nodes59

Edges58

Triples176

Avg. degree1.97

Density0.033898

Components1

Source & methodology

TTTA analyzes the structure around Factor H to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Clinical significance & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Factor H · EN edition · Analysis: TopicsToTalkAbout