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Endoglin

Endoglin (ENG) is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex. It is also commonly referred to as CD105, END, FLJ41744, HHT1, ORW and ORW1. It has a crucial role in angiogenesis, therefore, making it an important protein for tumor growth, survival and metastasis of cancer cells to other locations…

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Aliases
ENG, Eng, AI528660, AI662476, CD105, Endo, S-endoglin, END, HHT1, ORW1, endoglin
Band
9q34.11 · 2 B|2 22.09 cM
Bgee
right lung · right auricle of heart · apex of heart · right lobe of thyroid gland · left ovary
BioGPS
More reference expression data
Chr.
Chromosome 9 (human) · Chromosome 2 (mouse)
Databases
NCBI: entry; OMA: entry

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Map overview Semantic statistics

Endoglin

Nodes37
Edges36
Triples193
Avg. degree1.95
Density0.054054
Components1

How this topic connects Entity context

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Endoglin

Top relations

Gene ontology · 85
Endoglin → activin binding, angiogenesis, artery morphogenesis, atrial cardiac muscle tissue morphogenesis, atrioventricular canal morphogenesis, BMP binding, BMP signaling pathway, bone development, branching involved in blood vessel morphogenesis, cardiac atrium morphogenesis, cardiac ventricle morphogenesis, cell adhesion, cell chemotaxis, cell migration, cell migration involved in endocardial cushion formation, cell motility, cell surface, cellular response to mechanical stimulus, central nervous system vasculogenesis, detection of hypoxia
Bgee · 19
Endoglin → ankle joint, apex of heart, ascending aorta, cardiac muscle tissue of left ventricle, choroid plexus of fourth ventricle, Descending thoracic aorta, external carotid artery, Ileal epithelium, internal carotid artery, lactiferous gland, left ovary, right auricle of heart, right coronary artery, right lobe of thyroid gland, right lung, right lung lobe, right ovary, right ventricle, upper lobe of left lung
RNA expression pattern · 19
Endoglin → ankle joint, apex of heart, ascending aorta, cardiac muscle tissue of left ventricle, choroid plexus of fourth ventricle, Descending thoracic aorta, external carotid artery, Ileal epithelium, internal carotid artery, lactiferous gland, left ovary, right auricle of heart, right coronary artery, right lobe of thyroid gland, right lung, right lung lobe, right ovary, right ventricle, upper lobe of left lung
related to Structure · 12
Endoglin → BMP-9, However, It, L-endoglin, L-isoform, MMP-14, OR, S-endoglin, S-isoform, The, There, ZP
related to Function · 10
Endoglin → Beside TGF-beta, BMP-2, BMP-7, BMP-9, Experimental, It, Its, TGF-beta, TGF-beta1, TGF-beta3
related to Role in cancer · 10
Endoglin → Also, Being, Cancer, ECM, Hallmarks, However, In, TGF, The, The TGF
related to Interactions · 8
Endoglin → Furthermore, However, II, It, N-terminus, TGF, The, Unlike TGF
related to Clinical significance · 4
Endoglin → HHT, In, TGF, This
related to Gene and expression · 3
Endoglin → Other, The, This
Band · 2
Endoglin → 2 B|2 22.09 cM, 9q34.11

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Important terminology

beta tgf receptor cells gene human expression bp cancer cell role binding extracellular complex growth band domain chr tumor chromosome

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
EndoglinAliasesENG, Eng, AI528660, AI662476, CD105, Endo, S-endoglin, END, HHT1, ORW1, endoglin1.00infobox
EndoglinBand9q34.111.00infobox
EndoglinBand2 B|2 22.09 cM1.00infobox
EndoglinBgeeright lung1.00infobox
EndoglinBgeeright auricle of heart1.00infobox
EndoglinBgeeapex of heart1.00infobox
EndoglinBgeeright lobe of thyroid gland1.00infobox
EndoglinBgeeleft ovary1.00infobox
EndoglinBgeeright ovary1.00infobox
EndoglinBgeeright coronary artery1.00infobox
EndoglinBgeeupper lobe of left lung1.00infobox
EndoglinBgeeascending aorta1.00infobox
EndoglinBgeeDescending thoracic aorta1.00infobox
EndoglinBgeelactiferous gland1.00infobox
EndoglinBgeeankle joint1.00infobox
EndoglinBgeechoroid plexus of fourth ventricle1.00infobox
EndoglinBgeecardiac muscle tissue of left ventricle1.00infobox
EndoglinBgeeright lung lobe1.00infobox
EndoglinBgeeexternal carotid artery1.00infobox
EndoglinBgeeIleal epithelium1.00infobox
EndoglinBgeeinternal carotid artery1.00infobox
EndoglinBgeeright ventricle1.00infobox
EndoglinBioGPSMore reference expression data1.00infobox
EndoglinChr.Chromosome 9 (human)1.00infobox
EndoglinChr.Chromosome 2 (mouse)1.00infobox
EndoglinDatabasesNCBI: entry; OMA: entry1.00infobox
EndoglinEnd127,854,658 bp1.00infobox
EndoglinEnd32,572,681 bp1.00infobox
EndoglinEnsemblENSG000001069911.00infobox
EndoglinEntrez20221.00infobox

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