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Regorafenib

Regorafenib, sold under the brand name Stivarga among others, is an oral multi-kinase inhibitor developed by Bayer which targets angiogenic, stromal and oncogenic receptor tyrosine kinase (RTK). Regorafenib shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Since 2009 it was studied as a potential treatment…

Other actions, Approvals and indications & Adverse effects

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L01EX05 (WHO)
Bioavailability
69-83%
CAS Number
755037-03-7
ChEBI
CHEBI:68647

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Overview

Approvals and indications

Adverse effects

Other actions

Brand names

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Map overview Semantic statistics

Regorafenib

Nodes31
Edges30
Triples62
Avg. degree1.94
Density0.064516
Components1

How this topic connects Entity context

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Regorafenib

Top relations

related to Other actions · 10
Regorafenib → DHA, EDP, EDPs, EEQs, EETs, EPA, However, It, P450, These
Legal status · 5
Regorafenib → AU: S4 (Prescription only), CA: ℞-only, EU: Rx-only, UK: POM (Prescription only), US: ℞-only
related to Advanced hepatocellular carcinoma · 5
Regorafenib → Care Excellence, Health, In November, National Institute, NICE
related to Clinical trials · 5
Regorafenib → After, CONCUR, CONSIGN, CORRECT, MetastaticCRC
related to Advanced gastrointestinal stromal tumours · 4
Regorafenib → FDA-approved, In, In February, US FDA
related to Metastatic colorectal cancer · 4
Regorafenib → After, English Cancer Drugs Fund, September, US FDA
has effect · 3
Regorafenib → Boxed Warning, Serious, The
3D model (JSmol) · 1
Regorafenib → Interactive image
AHFS/Drugs.com · 1
Regorafenib → Monograph
ATC code · 1
Regorafenib → L01EX05 (WHO)

Important terminology Word statistics

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Important terminology

patients cancer advanced us effects stromal names approved treated tyrosine kinase liver clinical actions brand approvals name stivarga growth studies

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Regorafenib3D model (JSmol)Interactive image1.00infobox
RegorafenibAHFS/Drugs.comMonograph1.00infobox
RegorafenibATC codeL01EX05 (WHO)1.00infobox
RegorafenibBioavailability69-83%1.00infobox
RegorafenibCAS Number755037-03-71.00infobox
RegorafenibChEBICHEBI:686471.00infobox
RegorafenibChEMBLChEMBL19461701.00infobox
RegorafenibChemSpider93426971.00infobox
RegorafenibCompTox Dashboard (EPA)DTXSID602264411.00infobox
RegorafenibDrugBankDB088961.00infobox
RegorafenibECHA InfoCard100.248.9391.00infobox
RegorafenibElimination half-life20-30 hours1.00infobox
RegorafenibExcretionFeces (71%), urine (19%)1.00infobox
RegorafenibFormulaC21H15ClF4N4O31.00infobox
RegorafenibKEGGD101381.00infobox
RegorafenibLegal statusAU: S4 (Prescription only)1.00infobox
RegorafenibLegal statusCA: ℞-only1.00infobox
RegorafenibLegal statusUK: POM (Prescription only)1.00infobox
RegorafenibLegal statusUS: ℞-only1.00infobox
RegorafenibLegal statusEU: Rx-only1.00infobox
RegorafenibLicense dataUS DailyMed: Regorafenib1.00infobox
RegorafenibMedlinePlusa6130041.00infobox
RegorafenibMetabolismLiver (UGT1A9-mediated)1.00infobox
RegorafenibMolar mass482.82 g·mol−11.00infobox
RegorafenibOther namesBAY 73-45061.00infobox
RegorafenibPregnancy categoryAU: D1.00infobox
RegorafenibProtein binding99.5%1.00infobox
RegorafenibPubChem CID111676021.00infobox
RegorafenibRoutes of administrationBy mouth1.00infobox
RegorafenibTrade namesStivarga, Regonix1.00infobox

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