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Apolipoprotein E

Apolipoprotein E (Apo-E) is a protein involved in the transport of fats in the body of mammals. A subtype is implicated in Alzheimer's disease and cardiovascular diseases. It is encoded in humans by the gene APOE.

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Aliases
APOE, AD2, APO-E, LDLCQ5, LPG, apolipoprotein E, ApoE4
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1B68, 1BZ4, 1EA8, 1GS9, 1H7I, 1LE2, 1LE4, 1LPE, 1NFN, 1NFO, 1OEF, 1OEG, 1OR2, 1OR3, 2KC3, 2KNY, 2L7B
Band
19q13.32 · 7 A3|7 9.94 cM
Bgee
right adrenal cortex · left adrenal gland · left adrenal cortex · right lobe of liver · nucleus accumbens
BioGPS
More reference expression data
Chr.
Chromosome 19 (human) · Chromosome 7 (mouse)

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Apolipoprotein E

Nodes91
Edges90
Triples224
Avg. degree1.98
Density0.021978
Components1

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Apolipoprotein E

Top relations

Gene ontology · 128
Apolipoprotein E → AMPA glutamate receptor clustering, amyloid-beta binding, antioxidant activity, artery morphogenesis, blood microparticle, cellular calcium ion homeostasis, cellular oxidant detoxification, cGMP-mediated signaling, cholesterol binding, cholesterol catabolic process, cholesterol efflux, cholesterol homeostasis, cholesterol metabolic process, cholesterol transfer activity, chylomicron, chylomicron remnant clearance, cytoplasm, cytoskeleton organization, dendrite, early endosome
Bgee · 20
Apolipoprotein E → amygdala, C1 segment, CA3 field, caudate nucleus, choroid plexus of fourth ventricle, dentate gyrus of hippocampal formation granule cell, entorhinal cortex, gallbladder, hypothalamus, left adrenal cortex, left adrenal gland, left lobe of liver, nucleus accumbens, perirhinal cortex, putamen, right adrenal cortex, right lobe of liver, stroma of bone marrow, superior frontal gyrus, yolk sac
RNA expression pattern · 20
Apolipoprotein E → amygdala, C1 segment, CA3 field, caudate nucleus, choroid plexus of fourth ventricle, dentate gyrus of hippocampal formation granule cell, entorhinal cortex, gallbladder, hypothalamus, left adrenal cortex, left adrenal gland, left lobe of liver, nucleus accumbens, perirhinal cortex, putamen, right adrenal cortex, right lobe of liver, stroma of bone marrow, superior frontal gyrus, yolk sac
related to Alzheimer's disease · 17
Apolipoprotein E → AD, Alzheimer's, APOE-ε4, APOE4, ApoER2, Apolipoprotein, As, Caucasian, E4, However, Japanese, Just, Nigerian, Science, The, There, This
related to External links · 13
Apolipoprotein E → APOE, Apolipoprotein, Apolipoproteins, Human APOE, Medicine Medical Subject Headings, MeSH, National Library, Overview, P02649, PDB, PDBe-KB, UCSC Genome Browser, UniProt
Band · 2
Apolipoprotein E → 19q13.32, 7 A3|7 9.94 cM
Chr. · 2
Apolipoprotein E → Chromosome 19 (human), Chromosome 7 (mouse)
End · 2
Apolipoprotein E → 19,433,113 bp, 44,909,393 bp
Aliases · 1
Apolipoprotein E → APOE, AD2, APO-E, LDLCQ5, LPG, apolipoprotein E, ApoE4
Available structures · 1
Apolipoprotein E → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1B68, 1BZ4, 1EA8, 1GS9, 1H7I, 1LE2, 1LE4, 1LPE, 1NFN, 1NFO, 1OEF, 1OEG, 1OR2, 1OR3, 2KC3, 2KNY, 2L7B

Important terminology Word statistics

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Important terminology

apoe gene disease alzheimer's cholesterol apo-e allele ad apoe4 risk lipoprotein human alleles odds bp receptor protein transport liver apolipoprotein

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Apolipoprotein EAliasesAPOE, AD2, APO-E, LDLCQ5, LPG, apolipoprotein E, ApoE41.00infobox
Apolipoprotein EAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1B68, 1BZ4, 1EA8, 1GS9, 1H7I, 1LE2, 1LE4, 1LPE, 1NFN, 1NFO, 1OEF, 1OEG, 1OR2, 1OR3, 2KC3, 2KNY, 2L7B1.00infobox
Apolipoprotein EBand19q13.321.00infobox
Apolipoprotein EBand7 A3|7 9.94 cM1.00infobox
Apolipoprotein EBgeeright adrenal cortex1.00infobox
Apolipoprotein EBgeeleft adrenal gland1.00infobox
Apolipoprotein EBgeeleft adrenal cortex1.00infobox
Apolipoprotein EBgeeright lobe of liver1.00infobox
Apolipoprotein EBgeenucleus accumbens1.00infobox
Apolipoprotein EBgeeamygdala1.00infobox
Apolipoprotein EBgeehypothalamus1.00infobox
Apolipoprotein EBgeecaudate nucleus1.00infobox
Apolipoprotein EBgeeC1 segment1.00infobox
Apolipoprotein EBgeeputamen1.00infobox
Apolipoprotein EBgeeentorhinal cortex1.00infobox
Apolipoprotein EBgeestroma of bone marrow1.00infobox
Apolipoprotein EBgeechoroid plexus of fourth ventricle1.00infobox
Apolipoprotein EBgeeperirhinal cortex1.00infobox
Apolipoprotein EBgeeCA3 field1.00infobox
Apolipoprotein EBgeeleft lobe of liver1.00infobox
Apolipoprotein EBgeedentate gyrus of hippocampal formation granule cell1.00infobox
Apolipoprotein EBgeeyolk sac1.00infobox
Apolipoprotein EBgeegallbladder1.00infobox
Apolipoprotein EBgeesuperior frontal gyrus1.00infobox
Apolipoprotein EBioGPSMore reference expression data1.00infobox
Apolipoprotein EChr.Chromosome 19 (human)1.00infobox
Apolipoprotein EChr.Chromosome 7 (mouse)1.00infobox
Apolipoprotein EDatabasesNCBI: entry; OMA: entry1.00infobox
Apolipoprotein EEnd44,909,393 bp1.00infobox
Apolipoprotein EEnd19,433,113 bp1.00infobox

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