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Amphotericin B

Amphotericin B is an antifungal medication used for serious fungal infections and leishmaniasis. The fungal infections it is used to treat include mucormycosis, aspergillosis, blastomycosis, candidiasis, coccidioidomycosis, and cryptococcosis. It is sometimes used as a drug of last resort for primary amoebic meningoencephalitis. For certain infections it…

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
A01AB04 (WHO) A07AA07 (WHO), G01AA03 (WHO), J02AA01 (WHO)
Bioavailability
100% (IV) low (oral)
CAS Number
1397-89-3 Y
ChEBI
CHEBI:2682 Y

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Overview

Medical uses

Available formulations

Side effects

Interactions

Mechanism of action

Biosynthesis

History

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Map overview Semantic statistics

Amphotericin B

Nodes125
Edges124
Triples99
Avg. degree1.98
Density0.016
Components1

How this topic connects Entity context

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Amphotericin B

Top relations

has effect · 14
Amphotericin B → ABD, AmBisome, Amphotericin, Deoxycholate, Intravenously, Kidney, Less, Paracetamol, Reactions, The, This, To, Type, Very
related to Mechanism of action · 13
Amphotericin B → Amphotericin, B's, B/ergosterol, Cl, It, Na, Researchers, Scedosporium, The, This, Two, Van, Waals
related to By mouth · 7
Amphotericin B → AmbiOnp, An, GI, However, In, Matinas Biopharma, The
related to External links · 7
Amphotericin B → AmBisome Summaries, Amphotericin, Lipid Complex Injection, Liposomal Injection, MedlinePlus, Product Characteristics, United Kingdom
related to Mechanism of toxicity · 7
Amphotericin B → Amphotericin, Bacteria, Because, Ergosterol, Mammalian, Reactivity, This
related to Intravenous · 3
Amphotericin B → Amphotericin, Lipid-based, Therefore
Elimination half-life · 2
Amphotericin B → Initial phase: 24 hours, Second phase: approximately 15 days
Excretion · 2
Amphotericin B → 40% found in urine after single cumulated over several days, Biliary excretion is also important
Legal status · 2
Amphotericin B → In general: ℞ (Prescription only), US: ℞-only
3D model (JSmol) · 1
Amphotericin B → Interactive image

Important terminology Word statistics

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Important terminology

amphotericin drug fungal effects may side also used infections toxicity lipid deoxycholate formulations liposomal cell membrane serious complex kidney low

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Amphotericin B3D model (JSmol)Interactive image1.00infobox
Amphotericin BAHFS/Drugs.comMonograph1.00infobox
Amphotericin BATC codeA01AB04 (WHO) A07AA07 (WHO), G01AA03 (WHO), J02AA01 (WHO)1.00infobox
Amphotericin BBioavailability100% (IV) low (oral)1.00infobox
Amphotericin BCAS Number1397-89-3 Y1.00infobox
Amphotericin BChEBICHEBI:2682 Y1.00infobox
Amphotericin BChEMBLChEMBL267345 Y1.00infobox
Amphotericin BChemSpider10237579 Y1.00infobox
Amphotericin BCompTox Dashboard (EPA)DTXSID90226011.00infobox
Amphotericin BDrugBankDB00681 Y1.00infobox
Amphotericin BECHA InfoCard100.014.3111.00infobox
Amphotericin BElimination half-lifeInitial phase: 24 hours1.00infobox
Amphotericin BElimination half-lifeSecond phase: approximately 15 days1.00infobox
Amphotericin BExcretion40% found in urine after single cumulated over several days1.00infobox
Amphotericin BExcretionBiliary excretion is also important1.00infobox
Amphotericin BFormulaC47H73NO171.00infobox
Amphotericin BKEGGD00203 Y1.00infobox
Amphotericin BLegal statusUS: ℞-only1.00infobox
Amphotericin BLegal statusIn general: ℞ (Prescription only)1.00infobox
Amphotericin BLicense dataUS DailyMed: Amphotericin_B1.00infobox
Amphotericin BMedlinePlusa6826431.00infobox
Amphotericin BMelting point170 °C (338 °F)1.00infobox
Amphotericin BMetabolismkidney1.00infobox
Amphotericin BMolar mass924.091 g·mol−11.00infobox
Amphotericin BNIAID ChemDB0000961.00infobox
Amphotericin BPregnancy categoryAU: B21.00infobox
Amphotericin BPubChem CID52809651.00infobox
Amphotericin BRoutes of administrationIntravenous infusion1.00infobox
Amphotericin BTrade namesFungizone, Mysteclin-F, AmBisome and other1.00infobox
Amphotericin BUNII7XU7A7DROE1.00infobox

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