ADCY5

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Overview

Enzyme Gene Adenosine triphosphate Cyclic adenosine monophosphate Medium spiny neurons

27 related topics

Function

G proteins Protein kinase A G protein-coupled receptors GNAL D1 dopamine receptor

8 related topics

Interactions

Gβ2 Gγ7 Gβ1 Gγ2 Interact

6 related topics

Clinical significance

Central nervous system disorders Alcoholism Depression Autism Longevity

6 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

4.6.1.1: ↗
Aliases: ADCY5, AC5, FDFM, adenylate cyclase 5, DSKOD
Band: 3q21.1 · 16|16 B3
Bgee: apex of heart · gastric mucosa · right coronary artery · popliteal artery · tibial arteries
BioGPS: More reference expression data
Chr.: Chromosome 3 (human) · Chromosome 16 (mouse)

Topics to explore

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Overview

Enzyme
Gene
Adenosine triphosphate
Cyclic adenosine monophosphate
Medium spiny neurons Medium spiny neuron
Striatum
Movement disorders Movement disorder
Exome sequencing
Myoclonus
Chorea
Tremor
Dystonia
Dyskinesia
Hypotonia
Pyramidal syndrome Pyramidal signs
Psychiatric disorders Mental disorder
Intellectual disability
Heart failure
Autosomal dominant Dominance (genetics)
Mosaicism Mosaic (genetics)
Mutations Mutation
Caffeine
Istradefylline
Theophylline
Benzodiazepine
Deep brain stimulation
Globus pallidus internus Internal globus pallidus

Structure

ACs Adenylyl cyclase
Coiled-coil domain Coiled coil

Function

G proteins G protein
Protein kinase A
G protein-coupled receptors G protein-coupled receptor
GNAL
D1 dopamine receptor Dopamine receptor D1
Adenosine A2A receptor
D2 dopamine receptors Dopamine receptor D2
Adenosine A1 receptor

Interactions

Gβ2 GNB2
Gγ7 GNG7
Gβ1 GNB1
Gγ2 GNG2
Interact Protein-protein interaction
RGS2

Clinical significance

Central nervous system disorders Central nervous system disease
Alcoholism
Depression Major depressive disorder
Autism
Longevity
Stress Stress (biology)

Advanced semantic analysis

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Map overview Semantic statistics

Nodes55

Edges54

Triples130

Avg. degree1.96

Density0.036364

Components1

How this topic connects Entity context

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ADCY5

Top relations

Gene ontology · 37

ADCY5 → activation of adenylate cyclase activity, activation of protein kinase A activity, adenylate cyclase activity, adenylate cyclase binding, adenylate cyclase-activating dopamine receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, adenylate cyclase-inhibiting dopamine receptor signaling pathway, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, ATP binding, cAMP biosynthetic process, cell projection, cellular response to forskolin, cellular response to glucagon stimulus, cGMP biosynthetic process, cilium, cyclic nucleotide biosynthetic process, G protein-coupled adenosine receptor signaling pathway, G protein-coupled receptor signaling pathway, guanylate cyclase activity, guanylate cyclase complex, soluble

Bgee · 19

ADCY5 → amygdala, aortic valve, apex of heart, ascending aorta, cardiac muscle tissue of right atrium, gastric mucosa, globus pallidus, lateral septal nucleus, left ventricle, nucleus accumbens, nucleus of stria terminalis, olfactory tubercle, popliteal artery, putamen, right auricle of heart, right coronary artery, superior frontal gyrus, temporal lobe, tibial arteries

RNA expression pattern · 19

related to Structure · 15

ADCY5 → AC5, ACs, ATP, C-terminal, C1a, C1b, C2a, C2b, H1, H2, In, N-terminal, The, The AC5, The N-terminal

related to External links · 4

ADCY5 → Brain Institute, Human ADCY5, MxMD-ADCY5, UCSC Genome Browser

Band · 2

ADCY5 → 16|16 B3, 3q21.1

Chr. · 2

ADCY5 → Chromosome 16 (mouse), Chromosome 3 (human)

End · 2

ADCY5 → 123,449,090 bp, 35,126,108 bp

related to Mixed movement disorders · 2

ADCY5 → Mixed, MxMD-ADCY5

4.6.1.1 · 1

ADCY5 → ↗

Important terminology Word statistics

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Important terminology

ac5 gene camp activity human cyclase chromosome bp msns movement enzyme membrane protein chr band domain catalytic disorders striatum adenylyl

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
ADCY5	4.6.1.1	↗	1.00	infobox
ADCY5	Aliases	ADCY5, AC5, FDFM, adenylate cyclase 5, DSKOD	1.00	infobox
ADCY5	Band	3q21.1	1.00	infobox
ADCY5	Band	16\|16 B3	1.00	infobox
ADCY5	Bgee	apex of heart	1.00	infobox
ADCY5	Bgee	gastric mucosa	1.00	infobox
ADCY5	Bgee	right coronary artery	1.00	infobox
ADCY5	Bgee	popliteal artery	1.00	infobox
ADCY5	Bgee	tibial arteries	1.00	infobox
ADCY5	Bgee	right auricle of heart	1.00	infobox
ADCY5	Bgee	left ventricle	1.00	infobox
ADCY5	Bgee	putamen	1.00	infobox
ADCY5	Bgee	nucleus accumbens	1.00	infobox
ADCY5	Bgee	cardiac muscle tissue of right atrium	1.00	infobox
ADCY5	Bgee	olfactory tubercle	1.00	infobox
ADCY5	Bgee	ascending aorta	1.00	infobox
ADCY5	Bgee	globus pallidus	1.00	infobox
ADCY5	Bgee	superior frontal gyrus	1.00	infobox
ADCY5	Bgee	nucleus of stria terminalis	1.00	infobox
ADCY5	Bgee	aortic valve	1.00	infobox
ADCY5	Bgee	lateral septal nucleus	1.00	infobox
ADCY5	Bgee	temporal lobe	1.00	infobox
ADCY5	Bgee	amygdala	1.00	infobox
ADCY5	BioGPS	More reference expression data	1.00	infobox
ADCY5	Chr.	Chromosome 3 (human)	1.00	infobox
ADCY5	Chr.	Chromosome 16 (mouse)	1.00	infobox
ADCY5	Databases	NCBI: entry; OMA: entry	1.00	infobox
ADCY5	End	123,449,090 bp	1.00	infobox
ADCY5	End	35,126,108 bp	1.00	infobox
ADCY5	Ensembl	ENSG00000173175	1.00	infobox

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