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Actin, cytoplasmic 2: Clinical significance, Function & Structure

Actin, cytoplasmic 2, or gamma-actin is a protein that in humans is encoded by the ACTG1 gene. Gamma-actin is widely expressed in cellular cytoskeletons of many tissues; in adult striated muscle cells, gamma-actin is localized to Z-discs and costamere structures, which are responsible for force transduction and transmission in muscle cells. Mutations in…

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Actin, cytoplasmic 2 topic overview

The analysis highlights Clinical significance, Function and Structure as prominent areas in the source structure around Actin, cytoplasmic 2.

Related topics
50
Source areas
5
Connected nodes
55
Extracted relationships
93
Concept neighborhoods
13
Bridge connections
55

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 19 topics
Function · 13 topics
Overview · 8 topics
Structure · 6 topics
Interactions · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
ACTG1, ACT, ACTG, BRWS2, DFNA20, DFNA26, HEL-176, actin gamma 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5JLH
Band
17q25.3 · 11|11 E2
Bgee
mucosa of ileum · ventricular zone · amniotic fluid · embryo · ganglionic eminence
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Actin, cytoplasmic 2 connects Entity context

The extracted context around Actin, cytoplasmic 2 shows recurring relationship patterns in the source. For example, Actin, cytoplasmic 2 → actin cytoskeleton, actin filament, ATP binding, blood microparticle, cell junction assembly, cytoplasm, cytoskeleton, cytosol, dense body, ephrin receptor signaling pathway, extracellular exosome, extracellular matrix, extracellular space, Fc-gamma receptor signaling pathway involved in phagocytosis, filamentous actin, focal adhesion, identical protein binding, membrane, membrane organization, myelin sheath Another extracted example is Actin, cytoplasmic 2 → amniotic fluid, blastocyst, dentate gyrus of hippocampal formation granule cell, embryo, epiblast, epithelium of nasopharynx, ganglionic eminence, granulocyte, mesencephalon, mucosa of ileum, neural tube, parietal pleura, pericardium, placenta, primary visual cortex, spinal ganglia, stomach, ventricular zone, visceral pleura. Use these groups to spot repeated connection types before inspecting the individual relationships.

Actin, cytoplasmic 2

Top relations

Gene ontology · 32
Actin, cytoplasmic 2 → actin cytoskeleton, actin filament, ATP binding, blood microparticle, cell junction assembly, cytoplasm, cytoskeleton, cytosol, dense body, ephrin receptor signaling pathway, extracellular exosome, extracellular matrix, extracellular space, Fc-gamma receptor signaling pathway involved in phagocytosis, filamentous actin, focal adhesion, identical protein binding, membrane, membrane organization, myelin sheath
Bgee · 19
Actin, cytoplasmic 2 → amniotic fluid, blastocyst, dentate gyrus of hippocampal formation granule cell, embryo, epiblast, epithelium of nasopharynx, ganglionic eminence, granulocyte, mesencephalon, mucosa of ileum, neural tube, parietal pleura, pericardium, placenta, primary visual cortex, spinal ganglia, stomach, ventricular zone, visceral pleura
RNA expression pattern · 19
Actin, cytoplasmic 2 → amniotic fluid, blastocyst, dentate gyrus of hippocampal formation granule cell, embryo, epiblast, epithelium of nasopharynx, ganglionic eminence, granulocyte, mesencephalon, mucosa of ileum, neural tube, parietal pleura, pericardium, placenta, primary visual cortex, spinal ganglia, stomach, ventricular zone, visceral pleura
Band · 2
Actin, cytoplasmic 2 → 11|11 E2, 17q25.3
Chr. · 2
Actin, cytoplasmic 2 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
Actin, cytoplasmic 2 → 120,239,368 bp, 81,523,847 bp
Aliases · 1
Actin, cytoplasmic 2 → ACTG1, ACT, ACTG, BRWS2, DFNA20, DFNA26, HEL-176, actin gamma 1
Available structures · 1
Actin, cytoplasmic 2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5JLH
BioGPS · 1
Actin, cytoplasmic 2 → More reference expression data
Databases · 1
Actin, cytoplasmic 2 → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

actg1 gamma-actin actin human bp gene chr band muscle gamma myocytes protein identified patients chromosome 17 cytoskeleton location mutation cells

Actin, cytoplasmic 2 relationships Subject–Predicate–Object triples

TTTA extracted 93 structured relationships around Actin, cytoplasmic 2. Examples in this analysis include Actin, cytoplasmic 2 → Aliases → ACTG1, ACT, ACTG, BRWS2, DFNA20, DFNA26, HEL-176, actin gamma 1 and Actin, cytoplasmic 2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5JLH. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Actin, cytoplasmic 2AliasesACTG1, ACT, ACTG, BRWS2, DFNA20, DFNA26, HEL-176, actin gamma 11.00infobox
Actin, cytoplasmic 2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5JLH1.00infobox
Actin, cytoplasmic 2Band17q25.31.00infobox
Actin, cytoplasmic 2Band11|11 E21.00infobox
Actin, cytoplasmic 2Bgeemucosa of ileum1.00infobox
Actin, cytoplasmic 2Bgeeventricular zone1.00infobox
Actin, cytoplasmic 2Bgeeamniotic fluid1.00infobox
Actin, cytoplasmic 2Bgeeembryo1.00infobox
Actin, cytoplasmic 2Bgeeganglionic eminence1.00infobox
Actin, cytoplasmic 2Bgeeparietal pleura1.00infobox
Actin, cytoplasmic 2Bgeeepithelium of nasopharynx1.00infobox
Actin, cytoplasmic 2Bgeevisceral pleura1.00infobox
Actin, cytoplasmic 2Bgeespinal ganglia1.00infobox
Actin, cytoplasmic 2Bgeepericardium1.00infobox
Actin, cytoplasmic 2Bgeegranulocyte1.00infobox
Actin, cytoplasmic 2Bgeeneural tube1.00infobox
Actin, cytoplasmic 2Bgeemesencephalon1.00infobox
Actin, cytoplasmic 2Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
Actin, cytoplasmic 2Bgeeplacenta1.00infobox
Actin, cytoplasmic 2Bgeeprimary visual cortex1.00infobox
Actin, cytoplasmic 2Bgeeepiblast1.00infobox
Actin, cytoplasmic 2Bgeeblastocyst1.00infobox
Actin, cytoplasmic 2Bgeestomach1.00infobox
Actin, cytoplasmic 2BioGPSMore reference expression data1.00infobox
Actin, cytoplasmic 2Chr.Chromosome 17 (human)1.00infobox
Actin, cytoplasmic 2Chr.Chromosome 11 (mouse)1.00infobox
Actin, cytoplasmic 2DatabasesNCBI: entry; OMA: entry1.00infobox
Actin, cytoplasmic 2End81,523,847 bp1.00infobox
Actin, cytoplasmic 2End120,239,368 bp1.00infobox
Actin, cytoplasmic 2EnsemblENSG000001840091.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Actin, cytoplasmic 2 bring nearby vocabulary together. In this analysis, examples include Gamma, Gene and Location. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Actin, cytoplasmic 2
    • Gamma
    • Gene
    • Location
    • Human
    • Actg1
    • Cytoplasm
    • Encoded
    • Function
    • Structures
    • Cells
    • Chromosome
    • Protein
  • actin, cytoplasmic 2
    • Gamma
    • Gene
    • Location
    • Human
    • Actg1
    • Cytoplasm
    • Encoded
    • Function
    • Structures
    • Cells
    • Chromosome
    • Protein
  • gene
    • Location
    • Human
    • Chromosome
    • Bp
    • Chr
    • Cytoplasm
    • Mouse
    • Function
    • Structures
    • Band
    • Protein
    • Gamma
  • function
    • Chromosome
    • Location
    • Bp
    • Chr
    • Human
    • Gene
    • Cytoplasm
    • Mouse
    • Cell
    • Structures
    • Band
    • Cytoskeleton
  • z-discs
    • Cells
    • Muscle
    • Adult
    • Cellular
    • Expressed
    • Tissues
    • Costamere
    • Costameres
    • Shown
    • Structures
    • Gamma-actin
    • Myocytes
  • cytoplasm
    • Encoded
    • Expressed
    • Gene
    • Mouse
    • Function
    • Structures
    • Cytoskeleton
    • Location
    • Protein
    • Human
    • Myocytes
    • Gamma
  • costamere
    • Structures
    • Myocytes
    • Muscle
    • Cytoplasm
    • Encoded
    • Expressed
    • Tissues
    • Z-discs
    • Gamma-actin
    • Gamma
    • Gene
  • striated muscle
    • Tissues
    • Structures
    • Z-discs
    • Myocytes
    • Gamma
    • Cytoplasm
    • Actins
    • Function
    • Shown

Connections between topic areas Semantic bridges

For Actin, cytoplasmic 2, one of the stronger structural bridges in this analysis connects Actin, cytoplasmic 2 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Actin, cytoplasmic 2Clinical significance · splits 36 ⟂ 20
Actin, cytoplasmic 2Function · splits 42 ⟂ 14
Actin, cytoplasmic 2Overview · splits 47 ⟂ 9
Actin, cytoplasmic 2Structure · splits 49 ⟂ 7
Actin, cytoplasmic 2Interactions · splits 51 ⟂ 5

Map overview Semantic statistics

Actin, cytoplasmic 2

Nodes56
Edges55
Triples93
Avg. degree1.96
Density0.035714
Components1

Source & methodology

TTTA analyzes the structure around Actin, cytoplasmic 2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Function & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Actin, cytoplasmic 2 · EN edition · Analysis: TopicsToTalkAbout

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