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Actin, cytoplasmic 2

Actin, cytoplasmic 2, or gamma-actin is a protein that in humans is encoded by the ACTG1 gene. Gamma-actin is widely expressed in cellular cytoskeletons of many tissues; in adult striated muscle cells, gamma-actin is localized to Z-discs and costamere structures, which are responsible for force transduction and transmission in muscle cells. Mutations in…

Clinical significance, Function & Structure

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Clinical significance

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Function

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Structure

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Aliases
ACTG1, ACT, ACTG, BRWS2, DFNA20, DFNA26, HEL-176, actin gamma 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5JLH
Band
17q25.3 · 11|11 E2
Bgee
mucosa of ileum · ventricular zone · amniotic fluid · embryo · ganglionic eminence
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)

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Actin, cytoplasmic 2

Nodes56
Edges55
Triples93
Avg. degree1.96
Density0.035714
Components1

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Actin, cytoplasmic 2

Top relations

Gene ontology · 32
Actin, cytoplasmic 2 → actin cytoskeleton, actin filament, ATP binding, blood microparticle, cell junction assembly, cytoplasm, cytoskeleton, cytosol, dense body, ephrin receptor signaling pathway, extracellular exosome, extracellular matrix, extracellular space, Fc-gamma receptor signaling pathway involved in phagocytosis, filamentous actin, focal adhesion, identical protein binding, membrane, membrane organization, myelin sheath
Bgee · 19
Actin, cytoplasmic 2 → amniotic fluid, blastocyst, dentate gyrus of hippocampal formation granule cell, embryo, epiblast, epithelium of nasopharynx, ganglionic eminence, granulocyte, mesencephalon, mucosa of ileum, neural tube, parietal pleura, pericardium, placenta, primary visual cortex, spinal ganglia, stomach, ventricular zone, visceral pleura
RNA expression pattern · 19
Actin, cytoplasmic 2 → amniotic fluid, blastocyst, dentate gyrus of hippocampal formation granule cell, embryo, epiblast, epithelium of nasopharynx, ganglionic eminence, granulocyte, mesencephalon, mucosa of ileum, neural tube, parietal pleura, pericardium, placenta, primary visual cortex, spinal ganglia, stomach, ventricular zone, visceral pleura
Band · 2
Actin, cytoplasmic 2 → 11|11 E2, 17q25.3
Chr. · 2
Actin, cytoplasmic 2 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
Actin, cytoplasmic 2 → 120,239,368 bp, 81,523,847 bp
Aliases · 1
Actin, cytoplasmic 2 → ACTG1, ACT, ACTG, BRWS2, DFNA20, DFNA26, HEL-176, actin gamma 1
Available structures · 1
Actin, cytoplasmic 2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5JLH
BioGPS · 1
Actin, cytoplasmic 2 → More reference expression data
Databases · 1
Actin, cytoplasmic 2 → NCBI: entry; OMA: entry

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Important terminology

actg1 gamma-actin actin human bp gene chr band muscle gamma myocytes protein identified patients chromosome 17 cytoskeleton location mutation cells

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Actin, cytoplasmic 2AliasesACTG1, ACT, ACTG, BRWS2, DFNA20, DFNA26, HEL-176, actin gamma 11.00infobox
Actin, cytoplasmic 2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5JLH1.00infobox
Actin, cytoplasmic 2Band17q25.31.00infobox
Actin, cytoplasmic 2Band11|11 E21.00infobox
Actin, cytoplasmic 2Bgeemucosa of ileum1.00infobox
Actin, cytoplasmic 2Bgeeventricular zone1.00infobox
Actin, cytoplasmic 2Bgeeamniotic fluid1.00infobox
Actin, cytoplasmic 2Bgeeembryo1.00infobox
Actin, cytoplasmic 2Bgeeganglionic eminence1.00infobox
Actin, cytoplasmic 2Bgeeparietal pleura1.00infobox
Actin, cytoplasmic 2Bgeeepithelium of nasopharynx1.00infobox
Actin, cytoplasmic 2Bgeevisceral pleura1.00infobox
Actin, cytoplasmic 2Bgeespinal ganglia1.00infobox
Actin, cytoplasmic 2Bgeepericardium1.00infobox
Actin, cytoplasmic 2Bgeegranulocyte1.00infobox
Actin, cytoplasmic 2Bgeeneural tube1.00infobox
Actin, cytoplasmic 2Bgeemesencephalon1.00infobox
Actin, cytoplasmic 2Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
Actin, cytoplasmic 2Bgeeplacenta1.00infobox
Actin, cytoplasmic 2Bgeeprimary visual cortex1.00infobox
Actin, cytoplasmic 2Bgeeepiblast1.00infobox
Actin, cytoplasmic 2Bgeeblastocyst1.00infobox
Actin, cytoplasmic 2Bgeestomach1.00infobox
Actin, cytoplasmic 2BioGPSMore reference expression data1.00infobox
Actin, cytoplasmic 2Chr.Chromosome 17 (human)1.00infobox
Actin, cytoplasmic 2Chr.Chromosome 11 (mouse)1.00infobox
Actin, cytoplasmic 2DatabasesNCBI: entry; OMA: entry1.00infobox
Actin, cytoplasmic 2End81,523,847 bp1.00infobox
Actin, cytoplasmic 2End120,239,368 bp1.00infobox
Actin, cytoplasmic 2EnsemblENSG000001840091.00infobox

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