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Tissue factor pathway inhibitor

Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit factor Xa (Xa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa-tissue factor complex. TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5 nM.

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Aliases
TFPI, EPI, LACI, TFI, TFPI1, tissue factor pathway inhibitor
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4DTG, 1ADZ, 1IRH, 1TFX, 4BQD
Band
2q32.1 · 2|2 D
Bgee
right lung · lower lobe of lung · visceral pleura · upper lobe of lung · placenta
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 2 (mouse)

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Tissue factor pathway inhibitor

Nodes17
Edges16
Triples98
Avg. degree1.88
Density0.117647
Components1

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Tissue factor pathway inhibitor

Top relations

Gene ontology · 24
Tissue factor pathway inhibitor → anchored component of membrane, blood coagulation, blood coagulation, extrinsic pathway, caveola, cell surface, cellular response to interleukin-1, cellular response to lipopolysaccharide, cellular response to steroid hormone stimulus, endopeptidase inhibitor activity, endoplasmic reticulum, extracellular region, extracellular space, hemostasis, intracellular membrane-bounded organelle, membrane, negative regulation of blood coagulation, negative regulation of endopeptidase activity, negative regulation of peptidase activity, organelle membrane, peptidase inhibitor activity
Bgee · 19
Tissue factor pathway inhibitor → atrioventricular valve, decidua, dermis, efferent ductule, endocardial cushion, endothelial cell of lymphatic vessel, gastrula, liver, lower lobe of lung, pericardium, placenta, right lobe of liver, right lung, stromal cell of endometrium, umbilical cord, upper lobe of left lung, upper lobe of lung, vas deferens, visceral pleura
RNA expression pattern · 19
Tissue factor pathway inhibitor → atrioventricular valve, decidua, dermis, efferent ductule, endocardial cushion, endothelial cell of lymphatic vessel, gastrula, liver, lower lobe of lung, pericardium, placenta, right lobe of liver, right lung, stromal cell of endometrium, umbilical cord, upper lobe of left lung, upper lobe of lung, vas deferens, visceral pleura
related to External links · 11
Tissue factor pathway inhibitor → Man, OMIM, Online Mendelian Inheritance, Overview, P10646, PDB, PDBe-KB, TFPI1, TFPI2, Tissue, UniProt
Band · 2
Tissue factor pathway inhibitor → 2q32.1, 2|2 D
Chr. · 2
Tissue factor pathway inhibitor → Chromosome 2 (human), Chromosome 2 (mouse)
End · 2
Tissue factor pathway inhibitor → 187,565,760 bp, 84,307,119 bp
related to Interactions · 2
Tissue factor pathway inhibitor → Factor, Tissue
Aliases · 1
Tissue factor pathway inhibitor → TFPI, EPI, LACI, TFI, TFPI1, tissue factor pathway inhibitor
Available structures · 1
Tissue factor pathway inhibitor → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4DTG, 1ADZ, 1IRH, 1TFX, 4BQD

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Important terminology

tfpi bp human inhibitor chromosome factor chr band pathway gene xa tissue also location inhibit mouse nm protein external 152310

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Tissue factor pathway inhibitorAliasesTFPI, EPI, LACI, TFI, TFPI1, tissue factor pathway inhibitor1.00infobox
Tissue factor pathway inhibitorAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4DTG, 1ADZ, 1IRH, 1TFX, 4BQD1.00infobox
Tissue factor pathway inhibitorBand2q32.11.00infobox
Tissue factor pathway inhibitorBand2|2 D1.00infobox
Tissue factor pathway inhibitorBgeeright lung1.00infobox
Tissue factor pathway inhibitorBgeelower lobe of lung1.00infobox
Tissue factor pathway inhibitorBgeevisceral pleura1.00infobox
Tissue factor pathway inhibitorBgeeupper lobe of lung1.00infobox
Tissue factor pathway inhibitorBgeeplacenta1.00infobox
Tissue factor pathway inhibitorBgeeupper lobe of left lung1.00infobox
Tissue factor pathway inhibitorBgeestromal cell of endometrium1.00infobox
Tissue factor pathway inhibitorBgeeliver1.00infobox
Tissue factor pathway inhibitorBgeepericardium1.00infobox
Tissue factor pathway inhibitorBgeeright lobe of liver1.00infobox
Tissue factor pathway inhibitorBgeegastrula1.00infobox
Tissue factor pathway inhibitorBgeedecidua1.00infobox
Tissue factor pathway inhibitorBgeeatrioventricular valve1.00infobox
Tissue factor pathway inhibitorBgeevas deferens1.00infobox
Tissue factor pathway inhibitorBgeedermis1.00infobox
Tissue factor pathway inhibitorBgeeendocardial cushion1.00infobox
Tissue factor pathway inhibitorBgeeendothelial cell of lymphatic vessel1.00infobox
Tissue factor pathway inhibitorBgeeefferent ductule1.00infobox
Tissue factor pathway inhibitorBgeeumbilical cord1.00infobox
Tissue factor pathway inhibitorBioGPSMore reference expression data1.00infobox
Tissue factor pathway inhibitorChr.Chromosome 2 (human)1.00infobox
Tissue factor pathway inhibitorChr.Chromosome 2 (mouse)1.00infobox
Tissue factor pathway inhibitorDatabasesNCBI: entry; OMA: entry1.00infobox
Tissue factor pathway inhibitorEnd187,565,760 bp1.00infobox
Tissue factor pathway inhibitorEnd84,307,119 bp1.00infobox
Tissue factor pathway inhibitorEnsemblENSG000000034361.00infobox

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