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SR protein

SR proteins are a conserved family of proteins involved in RNA splicing. SR proteins are named because they contain a protein domain with long repeats of serine and arginine amino acid residues, whose standard abbreviations are "S" and "R" respectively. SR proteins are ~200-600 amino acids in length and composed of two domains, the RNA recognition motif…

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History

Structure

Location and translocation

Function

Diseases

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SR protein

Nodes84
Edges83
Triples120
Avg. degree1.98
Density0.02381
Components1

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SR protein

Top relations

related to history · 17
SR protein → B52, C-terminal, DNA, Drosophila, II, RNA, SF2/ASF, SR, SRp20, SRp40, SRp55, SRp75, SWAP, The, This, Tra, Tra-2
related to Structure · 15
SR protein → Based, C-terminal, Eight, From NMR, N-terminus, RNA, RRM, RRMH, RS, SR, SRSF1, The, The RRM, The RRMH, The RS
related to Genomic stabilization · 14
SR protein → C-terminal, DNA, II, Once RNA, RNA, S2F/ASF, SC35, SF2/ASF, SR, The, Topo, Topoisomerase, When Topo, When Topoisomerase
related to Splicing · 14
SR protein → Before, CDK9, CTD, Different, II, P-TEFb, RNA, Ser2, Ser5, SR, The, The CTD, The RS, YSPTSPS
related to mRNA export · 11
SR protein → If, NXF1, RNA, RRM, RS, Some SR, SR, TAP, The, Thus, When
related to HIV · 10
SR protein → All, HIV, HIV-1, New, One, SF2/ASF, SR, SRp40, SRp75, Three SR
related to Cancer · 9
SR protein → BRCA1, Elevated, ESE, Mutations, SC35, Several SR, SF2/ASF, SFRS1, SRp20
related to Location and translocation · 9
SR protein → II, Interchromatin, Localization, Partial, Perichromatin, Phosphorylation, RNA, RS, SR
related to Nonsense-mediated decay · 8
SR protein → For, If, It, NMD, SC35, SC35 SR, SR, The
related to Translation · 6
SR protein → High, MAPK-independent, MNK2, S6K1, SF2/ASF, SR

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Important terminology

sr proteins splicing rna domain protein nucleus mrna rs splice pre-mrna asf also translation sf2 bind exon ii alternative transcript

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
SR proteinrelated to CancerSeveral SR0.60section
SR proteinrelated to CancerElevated0.60section
SR proteinrelated to CancerSF2/ASF0.60section
SR proteinrelated to CancerSC350.60section
SR proteinrelated to CancerSRp200.60section
SR proteinrelated to CancerSFRS10.60section
SR proteinrelated to CancerMutations0.60section
SR proteinrelated to CancerESE0.60section
SR proteinrelated to CancerBRCA10.60section
SR proteinrelated to DiseasesGenetic0.60section
SR proteinrelated to DiseasesSR0.60section
SR proteinrelated to DiseasesMutations0.60section

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