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P-TEFb

The positive transcription elongation factor, P-TEFb, is a multiprotein complex that plays an essential role in the regulation of transcription by RNA polymerase II (Pol II) in eukaryotes. Immediately following initiation Pol II becomes trapped in promoter proximal paused positions on the majority of human genes (Figure 1). P-TEFb is a cyclin dependent…

Components, Regulation & Structure

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Components

Cyclin dependent kinaseCdk9Cyclin T1T2Bromodomain
8 related topics

Regulation

HEXIM1HEXIM2HnRNPs
3 related topics

Structure

Active siteViral protein
2 related topics

Overview

RNA polymerase IIEukaryotesDRBDSIFNegative elongation factor
8 related topics

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Overview

Components

Structure

Regulation

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Map overview Semantic statistics

P-TEFb

Nodes26
Edges25
Triples35
Avg. degree1.92
Density0.076923
Components1

How this topic connects Entity context

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P-TEFb

Top relations

related to Regulation · 15
P-TEFb → As, Because, Figure, For, HEXIM, HEXIM1, HEXIM2, In, La, LARP7, MEPCE, RNA, The, Two, When P-TEFb
related to Components · 11
P-TEFb → AIDS, BRD4, Cdk9, Drosophila, HIV, HIV Tat, Importantly, In, It, T1, T2
related to Structure · 7
P-TEFb → Cdk9, Figure, HIV Tat, T1, The, Three, X-ray
is a · 1
P-TEFb → cyclin dependent kinase that can phosphorylate the DRB sensitivity inducing factor
related to Discovery · 1
P-TEFb → Drosophila

Important terminology Word statistics

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Important terminology

7sk rna cyclin snrnp ii pol protein subunit elongation factor structure regulation drb subunits hexim transcription complex figure dependent kinase

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
P-TEFbis acyclin dependent kinase that can phosphorylate the DRB sensitivity inducing factor0.90text
P-TEFbrelated to ComponentsIt0.60section
P-TEFbrelated to ComponentsCdk90.60section
P-TEFbrelated to ComponentsDrosophila0.60section
P-TEFbrelated to ComponentsIn0.60section
P-TEFbrelated to ComponentsT10.60section
P-TEFbrelated to ComponentsT20.60section
P-TEFbrelated to ComponentsBRD40.60section
P-TEFbrelated to ComponentsImportantly0.60section
P-TEFbrelated to ComponentsAIDS0.60section
P-TEFbrelated to ComponentsHIV0.60section
P-TEFbrelated to ComponentsHIV Tat0.60section

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