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Gamma secretase

Gamma secretase is a multi-subunit protease complex, an integral membrane protein, that cleaves single-pass transmembrane proteins at residues within the transmembrane domain. Proteases of this type are known as intramembrane proteases. The most well-known substrate of gamma secretase is amyloid precursor protein, a large integral membrane protein that…

Measurement, Subunits and assembly & Function

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Key facts & relationships

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AlphaFold
IPR008710 · PF05450
Available protein structures:
IPR008710 · PF05450
InterPro
IPR008710
Membranome
155
OPM protein
[ 5fn5[
OPM superfamily
244

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Overview

Subunits and assembly

Cellular trafficking

Function

Advanced semantic analysis

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Map overview Semantic statistics

Gamma secretase

Nodes60
Edges59
Triples46
Avg. degree1.97
Density0.033333
Components1

How this topic connects Entity context

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Gamma secretase

Top relations

related to Function · 18
Gamma secretase → Although, Alzheimer's, APP, Aβ40, Aβ42, C-terminal, C-terminus, Certain, Earlier, EM, Gamma, In, Low-resolution, N-terminus, Notch, Substrate, The, X-ray
related to Subunits and assembly · 13
Gamma secretase → Alzheimer's, APH, APH-1, C-terminal, CD147, In, N-terminal, Nicastrin's, PEN-2, Presenilin, PSEN1, Recent, The
related to Cellular trafficking · 3
Gamma secretase → ER, Gamma, The
AlphaFold · 2
Gamma secretase → IPR008710, PF05450
Available protein structures: · 2
Gamma secretase → IPR008710, PF05450
InterPro · 1
Gamma secretase → IPR008710
Membranome · 1
Gamma secretase → 155
OPM protein · 1
Gamma secretase → [ 5fn5[
OPM superfamily · 1
Gamma secretase → 244
PDB · 1
Gamma secretase → IPR008710 PF05450 (ECOD; PDBsum)

Important terminology Word statistics

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Important terminology

gamma secretase complex protein presenilin membrane proteins amyloid aph-1 substrate nicastrin pen-2 integral also via microscopy type presenilin-1 protease cleavage

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Gamma secretaseAlphaFoldIPR0087101.00infobox
Gamma secretaseAlphaFoldPF054501.00infobox
Gamma secretaseAvailable protein structures:IPR0087101.00infobox
Gamma secretaseAvailable protein structures:PF054501.00infobox
Gamma secretaseInterProIPR0087101.00infobox
Gamma secretaseMembranome1551.00infobox
Gamma secretaseOPM protein[ 5fn5[1.00infobox
Gamma secretaseOPM superfamily2441.00infobox
Gamma secretasePDBIPR008710 PF05450 (ECOD; PDBsum)1.00infobox
Gamma secretasePfamPF054501.00infobox
Gamma secretaseSymbolGamma-secretase, γ-secretase1.00infobox
Gamma secretaseis amulti-subunit protease complex0.90text

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