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APH-1 (anterior pharynx-defective 1) is a protein originally identified in the round worm Caenorhabditis elegans as a regulator of the cell-surface localization of nicastrin and an essential component in the Notch signaling pathway.
Overview, Alternative splicing & Regulation of expression
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gamma-secretase complex aph1b aph1a activity components expression protein app cellular signaling essential notch nicastrin disease amyloid presenilin proteins alzheimer's production
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| APH-1 | Domains | InterPro | 1.00 | infobox |
| APH-1 | HGNC | 29509 | 1.00 | infobox |
| APH-1 | Locus | Chr. 1 p36.13-q31.3 | 1.00 | infobox |
| APH-1 | NCBI gene | 51107 | 1.00 | infobox |
| APH-1 | OMIM | 607629 | 1.00 | infobox |
| APH-1 | RefSeq | NM_016022 | 1.00 | infobox |
| APH-1 | Search for | Search forStructuresSwiss-modelDomainsInterPro | 1.00 | infobox |
| APH-1 | Structures | Swiss-model | 1.00 | infobox |
| APH-1 | Symbol | APH1A | 1.00 | infobox |
| APH-1 | UniProt | Q96BI3 | 1.00 | infobox |
| the Notch protein | instance of | The gamma-secretase complex is a multimeric protease responsible for the intramembrane proteolysis of transmembrane proteins | 0.80 | text |
| amyloid precursor protein | instance of | The gamma-secretase complex is a multimeric protease responsible for the intramembrane proteolysis of transmembrane proteins | 0.80 | text |
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