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SCN1B: Measurement, Clinical significance & Overview

Sodium channel subunit beta-1 is a protein that in humans is encoded by the SCN1B gene.

Language: English [EN]
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SCN1B topic overview

The analysis highlights Measurement, Clinical significance and Overview as prominent areas in the source structure around SCN1B.

Related topics
5
Source areas
2
Connected nodes
7
Extracted relationships
103
Related term clusters
6
Bridge connections
7

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 3 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SCN1B, ATFB13, BRGDA5, GEFSP1, sodium voltage-gated channel beta subunit 1, EIEE52, DEE52
Band
19q13.11 · 7 B1|7 19.3 cM
Bgee
primary visual cortex · right hemisphere of cerebellum · gastrocnemius muscle · right frontal lobe · muscle of thigh
BioGPS
More reference expression data
Chr.
Chromosome 19 (human) · Chromosome 7 (mouse)
Databases
NCBI: entry; OMA: entry

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SCN1B
5Protein · Gene · Brugada syndrome

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Clinical significance

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How SCN1B connects Entity context

The extracted context around SCN1B shows recurring relationship patterns in the source. For example, SCN1B → axon guidance, cardiac conduction, cardiac muscle cell action potential involved in contraction, cardiac muscle contraction, cell adhesion, chemical synaptic transmission, corticospinal neuron axon guidance, extracellular region, integral component of membrane, intercalated disc, ion transport, locomotion, membrane, membrane depolarization, membrane depolarization during cardiac muscle cell action potential, membrane depolarization during Purkinje myocyte cell action potential, neuronal action potential propagation, node of Ranvier, plasma membrane, positive regulation of neuron projection development Another extracted example is SCN1B → Brodmann area 9, CA3 field, cerebellar cortex, dentate gyrus of hippocampal formation granule cell, dorsolateral prefrontal cortex, extensor digitorum longus muscle, gastrocnemius muscle, muscle of thigh, perirhinal cortex, prefrontal cortex, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, skeletal muscle tissue, superior frontal gyrus, temporal muscle, triceps brachii muscle. Use these groups to spot repeated connection types before inspecting the individual relationships.

SCN1B

Top relations

Gene ontology · 42
SCN1B → axon guidance, cardiac conduction, cardiac muscle cell action potential involved in contraction, cardiac muscle contraction, cell adhesion, chemical synaptic transmission, corticospinal neuron axon guidance, extracellular region, integral component of membrane, intercalated disc, ion transport, locomotion, membrane, membrane depolarization, membrane depolarization during cardiac muscle cell action potential, membrane depolarization during Purkinje myocyte cell action potential, neuronal action potential propagation, node of Ranvier, plasma membrane, positive regulation of neuron projection development
Bgee · 17
SCN1B → Brodmann area 9, CA3 field, cerebellar cortex, dentate gyrus of hippocampal formation granule cell, dorsolateral prefrontal cortex, extensor digitorum longus muscle, gastrocnemius muscle, muscle of thigh, perirhinal cortex, prefrontal cortex, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, skeletal muscle tissue, superior frontal gyrus, temporal muscle, triceps brachii muscle
RNA expression pattern · 17
SCN1B → Brodmann area 9, CA3 field, cerebellar cortex, dentate gyrus of hippocampal formation granule cell, dorsolateral prefrontal cortex, extensor digitorum longus muscle, gastrocnemius muscle, muscle of thigh, perirhinal cortex, prefrontal cortex, primary visual cortex, right frontal lobe, right hemisphere of cerebellum, skeletal muscle tissue, superior frontal gyrus, temporal muscle, triceps brachii muscle
related to Clinical significance · 4
SCN1B → Brugada, Dravet Syndrome, GEFS, Mutation
Band · 2
SCN1B → 19q13.11, 7 B1|7 19.3 cM
Chr. · 2
SCN1B → Chromosome 19 (human), Chromosome 7 (mouse)
End · 2
SCN1B → 30,826,428 bp, 35,040,449 bp
Aliases · 1
SCN1B → SCN1B, ATFB13, BRGDA5, GEFSP1, sodium voltage-gated channel beta subunit 1, EIEE52, DEE52
BioGPS · 1
SCN1B → More reference expression data
Databases · 1
SCN1B → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp human sodium channel gene chr subunit band voltage-gated chromosome 19 protein location beta-1 alpha omim mouse propagation action muscle

SCN1B relationships Subject–Predicate–Object triples

TTTA extracted 103 structured relationships around SCN1B. Examples in this analysis include SCN1B → Aliases → SCN1B, ATFB13, BRGDA5, GEFSP1, sodium voltage-gated channel beta subunit 1, EIEE52, DEE52 and SCN1B → Band → 19q13.11. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
SCN1BAliasesSCN1B, ATFB13, BRGDA5, GEFSP1, sodium voltage-gated channel beta subunit 1, EIEE52, DEE521.00infobox
SCN1BBand19q13.111.00infobox
SCN1BBand7 B1|7 19.3 cM1.00infobox
SCN1BBgeeprimary visual cortex1.00infobox
SCN1BBgeeright hemisphere of cerebellum1.00infobox
SCN1BBgeegastrocnemius muscle1.00infobox
SCN1BBgeeright frontal lobe1.00infobox
SCN1BBgeemuscle of thigh1.00infobox
SCN1BBgeeskeletal muscle tissue1.00infobox
SCN1BBgeedorsolateral prefrontal cortex1.00infobox
SCN1BBgeeBrodmann area 91.00infobox
SCN1BBgeesuperior frontal gyrus1.00infobox
SCN1BBgeeprefrontal cortex1.00infobox
SCN1BBgeedentate gyrus of hippocampal formation granule cell1.00infobox
SCN1BBgeecerebellar cortex1.00infobox
SCN1BBgeeextensor digitorum longus muscle1.00infobox
SCN1BBgeeCA3 field1.00infobox
SCN1BBgeeperirhinal cortex1.00infobox
SCN1BBgeetriceps brachii muscle1.00infobox
SCN1BBgeetemporal muscle1.00infobox
SCN1BBioGPSMore reference expression data1.00infobox
SCN1BChr.Chromosome 19 (human)1.00infobox
SCN1BChr.Chromosome 7 (mouse)1.00infobox
SCN1BDatabasesNCBI: entry; OMA: entry1.00infobox
SCN1BEnd35,040,449 bp1.00infobox
SCN1BEnd30,826,428 bp1.00infobox
SCN1BEnsemblENSG000001057111.00infobox
SCN1BEntrez63241.00infobox
SCN1BExternal IDsOMIM: 600235; MGI: 98247; GeneCards: SCN1B1.00infobox
SCN1BGene location (Human)Gene location (Human)Chr.Chromosome 19 (human)Band19q13.11Start35,030,470 bpEnd35,040,449 bp1.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around SCN1B bring nearby vocabulary together. In this analysis, examples include Sodium, Subunit and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • SCN1B
    • Sodium
    • Subunit
    • Gene
    • Human
    • Alpha
    • Beta
    • Brugada
    • Entry
    • Ncbi
    • Syndrome
    • Location
    • Voltage-gated
  • scn1b
    • Sodium
    • Subunit
    • Gene
    • Human
    • Alpha
    • Beta
    • Brugada
    • Entry
    • Ncbi
    • Syndrome
    • Location
    • Voltage-gated
  • protein
    • Brugada
    • Entry
    • Ncbi
    • Syndrome
    • Scn1b
    • Sodium
    • Gene
    • Encoded
    • Human
    • Humans
    • Action
    • B1
  • gene
    • Location
    • Chromosome
    • B1
    • Bp
    • Chr
    • End
    • Human
    • Mouse
    • Scn1b
    • Sodium
    • Protein
    • Subunit
  • brugada syndrome
    • Entry
    • Ncbi
    • Syndrome
    • Protein
    • Channel
    • Human
    • Scn1b
    • Sodium
    • End
    • Mouse
    • Muscle
    • Neuronal
  • dravet syndrome
    • Voltage-gated

Connections between topic areas Semantic bridges

For SCN1B, one of the stronger structural bridges in this analysis connects SCN1B with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
SCN1B — Clinical significance · splits 4 ⟂ 4
SCN1B — Overview · splits 5 ⟂ 3

Map overview Semantic statistics

SCN1B

Nodes8
Edges7
Triples103
Avg. degree1.75
Density0.25
Components1

Source & methodology

TTTA analyzes the structure around SCN1B to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Clinical significance & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — SCN1B · EN edition · Analysis: TopicsToTalkAbout

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