Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

Crizotinib

Crizotinib, sold under the brand name Xalkori among others, is an anti-cancer medication used for the treatment of non-small cell lung carcinoma (NSCLC). Crizotinib inhibits the c-Met/Hepatocyte growth factor receptor (HGFR) tyrosine kinase, which is involved in the oncogenesis of a number of other histological forms of malignant neoplasms. It also acts…

Community, Culture, Applications & Research

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Research this topic

Explore the main themes, entities and connections around Crizotinib. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
L01ED01 (WHO)
Bioavailability
43%
CAS Number
877399-52-5 N
ChEBI
CHEBI:64310 N

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Mechanism of action

Society and culture

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Crizotinib

Nodes41
Edges40
Triples115
Avg. degree1.95
Density0.04878
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

Crizotinib

Top relations

related to External links · 41
Crizotinib → ALK, An Investigational Drug, Anaplastic Large Cell Lymphoma, Brentuximab Vedotin, C-Met/Hepatocyte Growth Factor Tyrosine, Cancer, Cisplatin Or Carboplatin In, Clinical, Clinical Trial Testing The, ClinicalTrials, Combination Chemotherapy, Diagnosed Stage II-IV Anaplastic, Efficacy Of Crizotinib Versus, Gene, In Patients With Advanced, Kinase Inhibitor, Large Cell Lymphoma, National Cancer Institute, NCI Drug Dictionary, NCT00585195
related to Legal status · 12
Crizotinib → ALK, Approval, Drug Administration, EMA, EML4-ALK, European Medicines Agency, FDA, In August, In March, In October, ROS1-positive, US Food
related to Lung cancer · 10
Crizotinib → Additionally, ALK, ALK-positive NSCLC, Approximately, Most, Phase III, PROFILE, Some, They, Tumors
related to Mechanism of action · 9
Crizotinib → About, ALK, ALK-fusion NSLC, ATP-binding, EGFR, EML4, K-Ras, Patients, The
related to Medical uses · 6
Crizotinib → ALCL, ALK, ALK-positive, IMT, It, NSCLC
Legal status · 5
Crizotinib → AU: S4 (Prescription only), CA: ℞-only, EU: Rx-only, UK: POM (Prescription only), US: ℞-only
related to Lymphomas · 4
Crizotinib → ALK, In, No, Treatment
3D model (JSmol) · 1
Crizotinib → Interactive image
AHFS/Drugs.com · 1
Crizotinib → Monograph
ATC code · 1
Crizotinib → L01ED01 (WHO)

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

kinase alk lymphoma lung cell treatment non-small anaplastic cancer malignant patients gene number tumors fusion nsclc growth also refractory factor

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Crizotinib3D model (JSmol)Interactive image1.00infobox
CrizotinibAHFS/Drugs.comMonograph1.00infobox
CrizotinibATC codeL01ED01 (WHO)1.00infobox
CrizotinibBioavailability43%1.00infobox
CrizotinibCAS Number877399-52-5 N1.00infobox
CrizotinibChEBICHEBI:64310 N1.00infobox
CrizotinibChEMBLChEMBL601719 Y1.00infobox
CrizotinibChemSpider9801307 Y1.00infobox
CrizotinibCompTox Dashboard (EPA)DTXSID7010093291.00infobox
CrizotinibDrugBankDB08700 Y1.00infobox
CrizotinibECHA InfoCard100.166.4401.00infobox
CrizotinibElimination half-life42 hours1.00infobox
CrizotinibExcretionFaeces (63%), urine (22%)1.00infobox
CrizotinibFormulaC21H22Cl2FN5O1.00infobox
CrizotinibIUPHAR/BPS49031.00infobox
CrizotinibKEGGD09731 N1.00infobox
CrizotinibLegal statusAU: S4 (Prescription only)1.00infobox
CrizotinibLegal statusCA: ℞-only1.00infobox
CrizotinibLegal statusUK: POM (Prescription only)1.00infobox
CrizotinibLegal statusUS: ℞-only1.00infobox
CrizotinibLegal statusEU: Rx-only1.00infobox
CrizotinibLicense dataUS DailyMed: Crizotinib1.00infobox
CrizotinibMedlinePlusa6120181.00infobox
CrizotinibMetabolismLiver (CYP3A4/CYP3A5-mediated)1.00infobox
CrizotinibMolar mass450.34 g·mol−11.00infobox
CrizotinibOther namesPF-02341066 10661.00infobox
CrizotinibPDB ligandVGH (PDBe, RCSB PDB)1.00infobox
CrizotinibPregnancy categoryAU: D1.00infobox
CrizotinibProtein binding91%1.00infobox
CrizotinibPubChem CID116265601.00infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

    Connections between topic areas Semantic bridges

    Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

    Min side: 3
    For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.