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Doublecortin: Applications, Function & Structure

Neuronal migration protein doublecortin, also known as doublin or lissencephalin-X, is a protein that in humans is encoded by the DCX gene.

Language: English [EN]
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Doublecortin topic overview

The analysis highlights Applications, Function and Structure as prominent areas in the source structure around Doublecortin.

Related topics
27
Source areas
6
Connected nodes
33
Extracted relationships
124
Concept neighborhoods
11
Bridge connections
33

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 11 topics
Structure · 6 topics
Clinical significance · 3 topics
Knock out mouse · 3 topics
Interactions · 2 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
DCX, DBCN, DC, LISX, SCLH, XLIS, doublecortin
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4ATU, 1MJD, 2BQQ, 2XRP, 5IN7, 5IOI, 5IKC, 5IP4, 5IO9
Band
Xq23 · X|X F2
Bgee
ganglionic eminence · ventricular zone · tail of epididymis · endothelial cell · Brodmann area 23
BioGPS
More reference expression data
Chr.
X chromosome (human) · X chromosome (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Knock out mouse

Structure

Interactions

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Doublecortin connects Entity context

The extracted context around Doublecortin shows recurring relationship patterns in the source. For example, Doublecortin → axoneme, axoneme assembly, cell differentiation, cell projection, central nervous system development, cytoplasm, cytoskeleton, cytosol, intracellular signal transduction, microtubule, microtubule associated complex, microtubule binding, multicellular organism development, nervous system development, neuron migration, neuron projection, photoreceptor cell development, protein binding, protein kinase binding, retina development in camera-type eye Another extracted example is Doublecortin → barrel cortex, Brodmann area 10, Brodmann area 23, Brodmann area 46, endothelial cell, fossa, ganglionic eminence, human fetus, medial ganglionic eminence, middle temporal gyrus, neural tube, olfactory bulb, primary visual cortex, Rostral migratory stream, secondary oocyte, superior cervical ganglion, tail of epididymis, trigeminal ganglion, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

Doublecortin

Top relations

Gene ontology · 20
Doublecortin → axoneme, axoneme assembly, cell differentiation, cell projection, central nervous system development, cytoplasm, cytoskeleton, cytosol, intracellular signal transduction, microtubule, microtubule associated complex, microtubule binding, multicellular organism development, nervous system development, neuron migration, neuron projection, photoreceptor cell development, protein binding, protein kinase binding, retina development in camera-type eye
Bgee · 19
Doublecortin → barrel cortex, Brodmann area 10, Brodmann area 23, Brodmann area 46, endothelial cell, fossa, ganglionic eminence, human fetus, medial ganglionic eminence, middle temporal gyrus, neural tube, olfactory bulb, primary visual cortex, Rostral migratory stream, secondary oocyte, superior cervical ganglion, tail of epididymis, trigeminal ganglion, ventricular zone
RNA expression pattern · 19
Doublecortin → barrel cortex, Brodmann area 10, Brodmann area 23, Brodmann area 46, endothelial cell, fossa, ganglionic eminence, human fetus, medial ganglionic eminence, middle temporal gyrus, neural tube, olfactory bulb, primary visual cortex, Rostral migratory stream, secondary oocyte, superior cervical ganglion, tail of epididymis, trigeminal ganglion, ventricular zone
related to External links · 14
Doublecortin → DCX-Related Disordersdoublecortin, DCX-Related DisordersOMIM, Media, Medicine Medical Subject Headings, MeSH, National Library, Neuronal, O43602, Overview, PDB, PDBe-KB, UniProt, Wikimedia CommonsGeneReviews/NCBI/NIH/UW, Wiktionary-logo-en-v2
related to Clinical significance · 9
Doublecortin → At, Boston, Christopher, Double, In, Joseph Gleeson, The, Walsh, X-linked
related to Function · 7
Doublecortin → BrdU, DCX, Downregulation, Due, Indeed, NeuN, Neuronal
related to Structure · 6
Doublecortin → DC, Doublecortin-like, It, Microtubule, The, These
related to Knock out mouse · 5
Doublecortin → CA3, However, In, The, These
Band · 2
Doublecortin → Xq23, X|X F2
Chr. · 2
Doublecortin → X chromosome (human), X chromosome (mouse)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

dcx protein bp gene chr human band migration neurons neuronal chromosome microtubule mouse also location cells proteins lissencephaly dc expression

Doublecortin relationships Subject–Predicate–Object triples

TTTA extracted 124 structured relationships around Doublecortin. Examples in this analysis include Doublecortin → Aliases → DCX, DBCN, DC, LISX, SCLH, XLIS, doublecortin and Doublecortin → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4ATU, 1MJD, 2BQQ, 2XRP, 5IN7, 5IOI, 5IKC, 5IP4, 5IO9. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
DoublecortinAliasesDCX, DBCN, DC, LISX, SCLH, XLIS, doublecortin1.00infobox
DoublecortinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4ATU, 1MJD, 2BQQ, 2XRP, 5IN7, 5IOI, 5IKC, 5IP4, 5IO91.00infobox
DoublecortinBandXq231.00infobox
DoublecortinBandX|X F21.00infobox
DoublecortinBgeeganglionic eminence1.00infobox
DoublecortinBgeeventricular zone1.00infobox
DoublecortinBgeetail of epididymis1.00infobox
DoublecortinBgeeendothelial cell1.00infobox
DoublecortinBgeeBrodmann area 231.00infobox
DoublecortinBgeemiddle temporal gyrus1.00infobox
DoublecortinBgeesecondary oocyte1.00infobox
DoublecortinBgeeprimary visual cortex1.00infobox
DoublecortinBgeeBrodmann area 101.00infobox
DoublecortinBgeeBrodmann area 461.00infobox
DoublecortinBgeeRostral migratory stream1.00infobox
DoublecortinBgeetrigeminal ganglion1.00infobox
DoublecortinBgeebarrel cortex1.00infobox
DoublecortinBgeemedial ganglionic eminence1.00infobox
DoublecortinBgeesuperior cervical ganglion1.00infobox
DoublecortinBgeehuman fetus1.00infobox
DoublecortinBgeefossa1.00infobox
DoublecortinBgeeneural tube1.00infobox
DoublecortinBgeeolfactory bulb1.00infobox
DoublecortinBioGPSMore reference expression data1.00infobox
DoublecortinChr.X chromosome (human)1.00infobox
DoublecortinChr.X chromosome (mouse)1.00infobox
DoublecortinDatabasesNCBI: entry; OMA: entry1.00infobox
DoublecortinEnd111,412,429 bp1.00infobox
DoublecortinEnd142,716,307 bp1.00infobox
DoublecortinEnsemblENSG000000772791.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Doublecortin bring nearby vocabulary together. In this analysis, examples include Protein, Microtubule and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Doublecortin
    • Protein
    • Microtubule
    • Gene
    • Dc
    • Migration
    • Neuronal
    • Dcx
    • Cytoskeleton
    • Entry
    • Function
    • O43602
    • Omim
  • doublecortin
    • Protein
    • Microtubule
    • Gene
    • Dc
    • Migration
    • Neuronal
    • Dcx
    • Cytoskeleton
    • Entry
    • Function
    • O43602
    • Omim
  • gene
    • Location
    • Mouse
    • Chromosome
    • Human
    • Bp
    • Chr
    • End
    • Function
    • Search
    • Band
    • Migration
    • Neuronal
  • pyramidal cells
    • Neuronal
    • Dcx
    • Neurons
    • Cytoskeleton
    • End
    • Entry
    • Function
    • O43602
    • Search
    • Uniprot
    • Cortex
    • Double
  • function
    • Search
    • Location
    • Mouse
    • Chromosome
    • External
    • Human
    • Bp
    • Chr
    • Cytoskeleton
    • End
    • Entry
    • Gene
  • cytoskeleton
    • Microtubule
    • End
    • Entry
    • Function
    • O43602
    • Search
    • Uniprot
    • Expression
    • Location
    • Mouse
    • Human
    • Migration
  • knock out mouse
    • Location
    • Human
    • End
    • Search
    • Band
    • Cytoskeleton
    • Entry
    • O43602
    • Omim
    • Pdb
    • Uniprot
    • Cortex
  • microtubule
    • Cytoskeleton
    • Entry
    • O43602
    • Search
    • Uniprot
    • Mouse
    • Migration
    • Neuronal
    • Neurons
    • Protein

Connections between topic areas Semantic bridges

For Doublecortin, one of the stronger structural bridges in this analysis connects Doublecortin with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
DoublecortinFunction · splits 22 ⟂ 12
DoublecortinStructure · splits 27 ⟂ 7
DoublecortinKnock out mouse · splits 30 ⟂ 4
DoublecortinClinical significance · splits 30 ⟂ 4
DoublecortinOverview · splits 31 ⟂ 3
DoublecortinInteractions · splits 31 ⟂ 3

Map overview Semantic statistics

Doublecortin

Nodes34
Edges33
Triples124
Avg. degree1.94
Density0.058824
Components1

Source & methodology

TTTA analyzes the structure around Doublecortin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications, Function & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Doublecortin · EN edition · Analysis: TopicsToTalkAbout

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