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RAPGEF4

Rap guanine nucleotide exchange factor (GEF) 4 (RAPGEF4), also known as exchange protein directly activated by cAMP 2 (EPAC2) is a protein that in humans is encoded by the RAPGEF4 gene.

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Aliases
RAPGEF4, CAMP-GEFII, CGEF2, EPAC, EPAC 2, EPAC2, Nbla00496, Rap guanine nucleotide exchange factor 4
Band
2q31.1 · 2|2 C3
Bgee
right frontal lobe · amygdala · dorsolateral prefrontal cortex · prefrontal cortex · Brodmann area 9
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 2 (mouse)
Databases
NCBI: entry; OMA: entry

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RAPGEF4

Nodes45
Edges44
Triples98
Avg. degree1.96
Density0.044444
Components1

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RAPGEF4

Top relations

Gene ontology · 19
RAPGEF4 → calcium-ion regulated exocytosis, cAMP binding, cAMP-mediated signaling, cytoplasm, cytosol, exocytosis, G protein-coupled receptor signaling pathway, guanyl-nucleotide exchange factor activity, hippocampal mossy fiber to CA3 synapse, insulin secretion, intracellular signal transduction, membrane, nucleotide binding, plasma membrane, protein binding, regulation of exocytosis, regulation of insulin secretion, regulation of synaptic vesicle cycle, small GTPase mediated signal transduction
Bgee · 18
RAPGEF4 → amygdala, anterior amygdaloid area, anterior cingulate cortex, Brodmann area 9, cingulate gyrus, dentate gyrus of hippocampal formation granule cell, dorsolateral prefrontal cortex, globus pallidus, habenula, hippocampus proper, lateral geniculate nucleus, lobe of cerebellum, nucleus accumbens, prefrontal cortex, right adrenal gland, right frontal lobe, superior frontal gyrus, ventral tegmental area
RNA expression pattern · 18
RAPGEF4 → amygdala, anterior amygdaloid area, anterior cingulate cortex, Brodmann area 9, cingulate gyrus, dentate gyrus of hippocampal formation granule cell, dorsolateral prefrontal cortex, globus pallidus, habenula, hippocampus proper, lateral geniculate nucleus, lobe of cerebellum, nucleus accumbens, prefrontal cortex, right adrenal gland, right frontal lobe, superior frontal gyrus, ventral tegmental area
related to Gene and transcripts · 16
RAPGEF4 → CDC25, CDC25-HD, DEP, Dishevelled, Egl-10, Epac2, Epac2A, Epac2B, Epac2C, Human Epac2, Pleckstrin, RA, Rap, Ras, REM, The
Band · 2
RAPGEF4 → 2q31.1, 2|2 C3
Chr. · 2
RAPGEF4 → Chromosome 2 (human), Chromosome 2 (mouse)
End · 2
RAPGEF4 → 173,052,893 bp, 72,087,818 bp
Aliases · 1
RAPGEF4 → RAPGEF4, CAMP-GEFII, CGEF2, EPAC, EPAC 2, EPAC2, Nbla00496, Rap guanine nucleotide exchange factor 4
BioGPS · 1
RAPGEF4 → More reference expression data
Databases · 1
RAPGEF4 → NCBI: entry; OMA: entry

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Important terminology

epac2 camp gene exchange bp secretion rap human nucleotide factor signaling insulin chr band stimulation involved cells chromosome protein expressed

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
RAPGEF4AliasesRAPGEF4, CAMP-GEFII, CGEF2, EPAC, EPAC 2, EPAC2, Nbla00496, Rap guanine nucleotide exchange factor 41.00infobox
RAPGEF4Band2q31.11.00infobox
RAPGEF4Band2|2 C31.00infobox
RAPGEF4Bgeeright frontal lobe1.00infobox
RAPGEF4Bgeeamygdala1.00infobox
RAPGEF4Bgeedorsolateral prefrontal cortex1.00infobox
RAPGEF4Bgeeprefrontal cortex1.00infobox
RAPGEF4BgeeBrodmann area 91.00infobox
RAPGEF4Bgeecingulate gyrus1.00infobox
RAPGEF4Bgeehippocampus proper1.00infobox
RAPGEF4Bgeeanterior cingulate cortex1.00infobox
RAPGEF4Bgeenucleus accumbens1.00infobox
RAPGEF4Bgeeright adrenal gland1.00infobox
RAPGEF4Bgeeglobus pallidus1.00infobox
RAPGEF4Bgeelateral geniculate nucleus1.00infobox
RAPGEF4Bgeesuperior frontal gyrus1.00infobox
RAPGEF4Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
RAPGEF4Bgeehabenula1.00infobox
RAPGEF4Bgeeanterior amygdaloid area1.00infobox
RAPGEF4Bgeeventral tegmental area1.00infobox
RAPGEF4Bgeelobe of cerebellum1.00infobox
RAPGEF4BioGPSMore reference expression data1.00infobox
RAPGEF4Chr.Chromosome 2 (human)1.00infobox
RAPGEF4Chr.Chromosome 2 (mouse)1.00infobox
RAPGEF4DatabasesNCBI: entry; OMA: entry1.00infobox
RAPGEF4End173,052,893 bp1.00infobox
RAPGEF4End72,087,818 bp1.00infobox
RAPGEF4EnsemblENSG000000914281.00infobox
RAPGEF4Entrez110691.00infobox
RAPGEF4External IDsOMIM: 606058; MGI: 1917723; GeneCards: RAPGEF41.00infobox

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