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Rap guanine nucleotide exchange factor (GEF) 4 (RAPGEF4), also known as exchange protein directly activated by cAMP 2 (EPAC2) is a protein that in humans is encoded by the RAPGEF4 gene.
The analysis highlights Regions, Function and Gene and transcripts as prominent areas in the source structure around RAPGEF4.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around RAPGEF4 shows recurring relationship patterns in the source. For example, RAPGEF4 → calcium-ion regulated exocytosis, cAMP binding, cAMP-mediated signaling, cytoplasm, cytosol, exocytosis, G protein-coupled receptor signaling pathway, guanyl-nucleotide exchange factor activity, hippocampal mossy fiber to CA3 synapse, insulin secretion, intracellular signal transduction, membrane, nucleotide binding, plasma membrane, protein binding, regulation of exocytosis, regulation of insulin secretion, regulation of synaptic vesicle cycle, small GTPase mediated signal transduction Another extracted example is RAPGEF4 → amygdala, anterior amygdaloid area, anterior cingulate cortex, Brodmann area 9, cingulate gyrus, dentate gyrus of hippocampal formation granule cell, dorsolateral prefrontal cortex, globus pallidus, habenula, hippocampus proper, lateral geniculate nucleus, lobe of cerebellum, nucleus accumbens, prefrontal cortex, right adrenal gland, right frontal lobe, superior frontal gyrus, ventral tegmental area. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
epac2 camp gene exchange bp secretion rap human nucleotide factor signaling insulin chr band stimulation involved cells chromosome protein expressed
TTTA extracted 98 structured relationships around RAPGEF4. Examples in this analysis include RAPGEF4 → Aliases → RAPGEF4, CAMP-GEFII, CGEF2, EPAC, EPAC 2, EPAC2, Nbla00496, Rap guanine nucleotide exchange factor 4 and RAPGEF4 → Band → 2q31.1. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| RAPGEF4 | Aliases | RAPGEF4, CAMP-GEFII, CGEF2, EPAC, EPAC 2, EPAC2, Nbla00496, Rap guanine nucleotide exchange factor 4 | 1.00 | infobox |
| RAPGEF4 | Band | 2q31.1 | 1.00 | infobox |
| RAPGEF4 | Band | 2|2 C3 | 1.00 | infobox |
| RAPGEF4 | Bgee | right frontal lobe | 1.00 | infobox |
| RAPGEF4 | Bgee | amygdala | 1.00 | infobox |
| RAPGEF4 | Bgee | dorsolateral prefrontal cortex | 1.00 | infobox |
| RAPGEF4 | Bgee | prefrontal cortex | 1.00 | infobox |
| RAPGEF4 | Bgee | Brodmann area 9 | 1.00 | infobox |
| RAPGEF4 | Bgee | cingulate gyrus | 1.00 | infobox |
| RAPGEF4 | Bgee | hippocampus proper | 1.00 | infobox |
| RAPGEF4 | Bgee | anterior cingulate cortex | 1.00 | infobox |
| RAPGEF4 | Bgee | nucleus accumbens | 1.00 | infobox |
| RAPGEF4 | Bgee | right adrenal gland | 1.00 | infobox |
| RAPGEF4 | Bgee | globus pallidus | 1.00 | infobox |
| RAPGEF4 | Bgee | lateral geniculate nucleus | 1.00 | infobox |
| RAPGEF4 | Bgee | superior frontal gyrus | 1.00 | infobox |
| RAPGEF4 | Bgee | dentate gyrus of hippocampal formation granule cell | 1.00 | infobox |
| RAPGEF4 | Bgee | habenula | 1.00 | infobox |
| RAPGEF4 | Bgee | anterior amygdaloid area | 1.00 | infobox |
| RAPGEF4 | Bgee | ventral tegmental area | 1.00 | infobox |
| RAPGEF4 | Bgee | lobe of cerebellum | 1.00 | infobox |
| RAPGEF4 | BioGPS | More reference expression data | 1.00 | infobox |
| RAPGEF4 | Chr. | Chromosome 2 (human) | 1.00 | infobox |
| RAPGEF4 | Chr. | Chromosome 2 (mouse) | 1.00 | infobox |
| RAPGEF4 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| RAPGEF4 | End | 173,052,893 bp | 1.00 | infobox |
| RAPGEF4 | End | 72,087,818 bp | 1.00 | infobox |
| RAPGEF4 | Ensembl | ENSG00000091428 | 1.00 | infobox |
| RAPGEF4 | Entrez | 11069 | 1.00 | infobox |
| RAPGEF4 | External IDs | OMIM: 606058; MGI: 1917723; GeneCards: RAPGEF4 | 1.00 | infobox |
The concept neighborhoods around RAPGEF4 bring nearby vocabulary together. In this analysis, examples include Signaling, Secretion and Exocytosis. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For RAPGEF4, one of the stronger structural bridges in this analysis connects RAPGEF4 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around RAPGEF4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions, Function & Gene and transcripts, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — RAPGEF4 · EN edition · Analysis: TopicsToTalkAbout