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Pregnane X receptor

In the field of molecular biology, the pregnane X receptor (PXR), also known as the steroid and xenobiotic sensing nuclear receptor (SXR) or nuclear receptor subfamily 1, group I, member 2 (NR1I2) is a protein that in humans is encoded by the NR1I2 (nuclear Receptor subfamily 1, group I, member 2) gene.

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Aliases
NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR, nuclear receptor subfamily 1 group I member 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ILG, 1ILH, 1M13, 1NRL, 1SKX, 2O9I, 2QNV, 3CTB, 3HVL, 3R8D, 4J5W, 4J5X, 4NY9, 4S0S, 4S0T, 4XHD, 4X1F, 4X1G,…
Band
3q13.33 · 16|16 B3
Bgee
right lobe of liver · jejunal mucosa · mucosa of transverse colon · duodenum · rectum
BioGPS
More reference expression data
Chr.
Chromosome 3 (human) · Chromosome 16 (mouse)

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Mechanism

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Map overview Semantic statistics

Pregnane X receptor

Nodes52
Edges51
Triples105
Avg. degree1.96
Density0.038462
Components1

How this topic connects Entity context

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Pregnane X receptor

Top relations

Gene ontology · 37
Pregnane X receptor → cell differentiation, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, intermediate filament cytoskeleton, intracellular receptor signaling pathway, metal ion binding, multicellular organism development, negative regulation of transcription, DNA-templated, nuclear body, nuclear receptor activity, nuclear receptor coactivator activity, nucleoplasm, nucleus, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, positive regulation of transcription, DNA-templated, protein binding, regulation of transcription, DNA-templated
Bgee · 19
Pregnane X receptor → appendix, cecum, colon, crypt of lieberkuhn of small intestine, duodenum, female urethra, gallbladder, ileum, intestinal villus, jejunal mucosa, jejunum, left colon, left lobe of liver, lumbar subsegment of spinal cord, mucosa of ileum, mucosa of sigmoid colon, mucosa of transverse colon, rectum, right lobe of liver
RNA expression pattern · 19
Pregnane X receptor → appendix, cecum, colon, crypt of lieberkuhn of small intestine, duodenum, female urethra, gallbladder, ileum, intestinal villus, jejunal mucosa, jejunum, left colon, left lobe of liver, lumbar subsegment of spinal cord, mucosa of ileum, mucosa of sigmoid colon, mucosa of transverse colon, rectum, right lobe of liver
Band · 2
Pregnane X receptor → 16|16 B3, 3q13.33
Chr. · 2
Pregnane X receptor → Chromosome 16 (mouse), Chromosome 3 (human)
End · 2
Pregnane X receptor → 119,818,487 bp, 38,115,186 bp
Aliases · 1
Pregnane X receptor → NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR, nuclear receptor subfamily 1 group I member 2
Available structures · 1
Pregnane X receptor → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ILG, 1ILH, 1M13, 1NRL, 1SKX, 2O9I, 2QNV, 3CTB, 3HVL, 3R8D, 4J5W, 4J5X, 4NY9, 4S0S, 4S0T, 4XHD, 4X1F, 4X1G,…
BioGPS · 1
Pregnane X receptor → More reference expression data
Databases · 1
Pregnane X receptor → NCBI: entry; OMA: entry

Important terminology Word statistics

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Important terminology

pxr receptor gene nuclear bp chr human band chromosome nr1i2 also expression location function cyp3a4 protein mouse ii molecular steroid

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Pregnane X receptorAliasesNR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR, nuclear receptor subfamily 1 group I member 21.00infobox
Pregnane X receptorAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ILG, 1ILH, 1M13, 1NRL, 1SKX, 2O9I, 2QNV, 3CTB, 3HVL, 3R8D, 4J5W, 4J5X, 4NY9, 4S0S, 4S0T, 4XHD, 4X1F, 4X1G,…1.00infobox
Pregnane X receptorBand3q13.331.00infobox
Pregnane X receptorBand16|16 B31.00infobox
Pregnane X receptorBgeeright lobe of liver1.00infobox
Pregnane X receptorBgeejejunal mucosa1.00infobox
Pregnane X receptorBgeemucosa of transverse colon1.00infobox
Pregnane X receptorBgeeduodenum1.00infobox
Pregnane X receptorBgeerectum1.00infobox
Pregnane X receptorBgeemucosa of ileum1.00infobox
Pregnane X receptorBgeemucosa of sigmoid colon1.00infobox
Pregnane X receptorBgeegallbladder1.00infobox
Pregnane X receptorBgeececum1.00infobox
Pregnane X receptorBgeeappendix1.00infobox
Pregnane X receptorBgeejejunum1.00infobox
Pregnane X receptorBgeecrypt of lieberkuhn of small intestine1.00infobox
Pregnane X receptorBgeecolon1.00infobox
Pregnane X receptorBgeeleft colon1.00infobox
Pregnane X receptorBgeeleft lobe of liver1.00infobox
Pregnane X receptorBgeeileum1.00infobox
Pregnane X receptorBgeefemale urethra1.00infobox
Pregnane X receptorBgeelumbar subsegment of spinal cord1.00infobox
Pregnane X receptorBgeeintestinal villus1.00infobox
Pregnane X receptorBioGPSMore reference expression data1.00infobox
Pregnane X receptorChr.Chromosome 3 (human)1.00infobox
Pregnane X receptorChr.Chromosome 16 (mouse)1.00infobox
Pregnane X receptorDatabasesNCBI: entry; OMA: entry1.00infobox
Pregnane X receptorEnd119,818,487 bp1.00infobox
Pregnane X receptorEnd38,115,186 bp1.00infobox
Pregnane X receptorEnsemblENSG000001448521.00infobox

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