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PRMT1: Interactions, Reaction pathway & Overview

Protein arginine N-methyltransferase 1 is an enzyme that in humans is encoded by the PRMT1 gene. The HRMT1L2 gene encodes a protein arginine methyltransferase that functions as a histone methyltransferase specific for histone H4.

Language: English [EN]
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PRMT1 topic overview

The analysis highlights Interactions, Reaction pathway and Overview as prominent areas in the source structure around PRMT1.

Related topics
19
Source areas
3
Connected nodes
22
Extracted relationships
123
Concept neighborhoods
10
Bridge connections
22

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 11 topics
Overview · 6 topics
Reaction pathway · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.1.1.319
2.1.1.321
Aliases
PRMT1, ANM1, HCP1, HRMT1L2, IR1B4, protein arginine methyltransferase 1
Band
19q13.33 · 7 B3|7 29.07 cM
Bgee
embryo · right uterine tube · ganglionic eminence · anterior pituitary · body of uterus
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Reaction pathway

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PRMT1 connects Entity context

The extracted context around PRMT1 shows recurring relationship patterns in the source. For example, PRMT1 → cell surface receptor signaling pathway, cytoplasm, cytosol, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, enzyme binding, histone arginine methylation, histone H4-R3 methylation, histone methylation, histone methyltransferase activity, histone methyltransferase activity (H4-R3 specific), histone-arginine N-methyltransferase activity, identical protein binding, in utero embryonic development, methyl-CpG binding, methylation, methylosome, methyltransferase activity, mitogen-activated protein kinase p38 binding, N-methyltransferase activity, negative regulation of megakaryocyte differentiation Another extracted example is PRMT1 → abdominal wall, anterior pituitary, body of uterus, canal of the cervix, dermis, embryo, ganglionic eminence, hand, left uterine tube, mandibular prominence, maxillary prominence, medial ganglionic eminence, muscle of thigh, right hemisphere of cerebellum, right ovary, right uterine tube, somite, tail of embryo, ventricular zone, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.

PRMT1

Top relations

Gene ontology · 42
PRMT1 → cell surface receptor signaling pathway, cytoplasm, cytosol, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, enzyme binding, histone arginine methylation, histone H4-R3 methylation, histone methylation, histone methyltransferase activity, histone methyltransferase activity (H4-R3 specific), histone-arginine N-methyltransferase activity, identical protein binding, in utero embryonic development, methyl-CpG binding, methylation, methylosome, methyltransferase activity, mitogen-activated protein kinase p38 binding, N-methyltransferase activity, negative regulation of megakaryocyte differentiation
Bgee · 20
PRMT1 → abdominal wall, anterior pituitary, body of uterus, canal of the cervix, dermis, embryo, ganglionic eminence, hand, left uterine tube, mandibular prominence, maxillary prominence, medial ganglionic eminence, muscle of thigh, right hemisphere of cerebellum, right ovary, right uterine tube, somite, tail of embryo, ventricular zone, yolk sac
RNA expression pattern · 20
PRMT1 → abdominal wall, anterior pituitary, body of uterus, canal of the cervix, dermis, embryo, ganglionic eminence, hand, left uterine tube, mandibular prominence, maxillary prominence, medial ganglionic eminence, muscle of thigh, right hemisphere of cerebellum, right ovary, right uterine tube, somite, tail of embryo, ventricular zone, yolk sac
related to Interactions · 9
PRMT1 → BTG1, BTG2, DHX9, FUS, HNRNPR, HNRPK, IFNAR1, ILF3, KHDRBS1
related to Reaction pathway · 6
PRMT1 → Individual PRMT, PRMT, PRMT2, S-adenosyl-L-methionine, SAM, While
related to Function · 3
PRMT1 → H4, Specifically, Through
Band · 2
PRMT1 → 19q13.33, 7 B3|7 29.07 cM
Chr. · 2
PRMT1 → Chromosome 19 (human), Chromosome 7 (mouse)
End · 2
PRMT1 → 44,635,992 bp, 49,689,029 bp
2.1.1.319 · 1
PRMT1 → ↗

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

arginine gene protein bp human methyltransferase chr band enzyme chromosome 19 histone n-methyltransferase specific location h4 mouse expression hrmt1l2 function

PRMT1 relationships Subject–Predicate–Object triples

TTTA extracted 123 structured relationships around PRMT1. Examples in this analysis include PRMT1 → 2.1.1.319 → ↗ and PRMT1 → Aliases → PRMT1, ANM1, HCP1, HRMT1L2, IR1B4, protein arginine methyltransferase 1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PRMT12.1.1.3191.00infobox
PRMT12.1.1.3211.00infobox
PRMT1AliasesPRMT1, ANM1, HCP1, HRMT1L2, IR1B4, protein arginine methyltransferase 11.00infobox
PRMT1Band19q13.331.00infobox
PRMT1Band7 B3|7 29.07 cM1.00infobox
PRMT1Bgeeembryo1.00infobox
PRMT1Bgeeright uterine tube1.00infobox
PRMT1Bgeeganglionic eminence1.00infobox
PRMT1Bgeeanterior pituitary1.00infobox
PRMT1Bgeebody of uterus1.00infobox
PRMT1Bgeecanal of the cervix1.00infobox
PRMT1Bgeemuscle of thigh1.00infobox
PRMT1Bgeeright hemisphere of cerebellum1.00infobox
PRMT1Bgeeleft uterine tube1.00infobox
PRMT1Bgeeright ovary1.00infobox
PRMT1Bgeeabdominal wall1.00infobox
PRMT1Bgeemandibular prominence1.00infobox
PRMT1Bgeeventricular zone1.00infobox
PRMT1Bgeemaxillary prominence1.00infobox
PRMT1Bgeemedial ganglionic eminence1.00infobox
PRMT1Bgeehand1.00infobox
PRMT1Bgeeyolk sac1.00infobox
PRMT1Bgeesomite1.00infobox
PRMT1Bgeedermis1.00infobox
PRMT1Bgeetail of embryo1.00infobox
PRMT1BioGPSMore reference expression data1.00infobox
PRMT1Chr.Chromosome 19 (human)1.00infobox
PRMT1Chr.Chromosome 7 (mouse)1.00infobox
PRMT1DatabasesNCBI: entry; OMA: entry1.00infobox
PRMT1End49,689,029 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PRMT1 bring nearby vocabulary together. In this analysis, examples include Protein, Activity and Asymmetric. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • PRMT1
    • Protein
    • Activity
    • Asymmetric
    • Function
    • Methylation
    • Pathway
    • Gene
    • Location
    • Chromosome
    • Methyltransferase
    • Bp
    • Chr
  • prmt1
    • Protein
    • Activity
    • Asymmetric
    • Function
    • Methylation
    • Pathway
    • Gene
    • Location
    • Chromosome
    • Methyltransferase
    • Bp
    • Chr
  • enzyme
    • Methyltransferase
    • Activity
    • Function
    • Pathway
    • Prmt1
    • Protein
    • Location
    • N-methyltransferase
    • Gene
    • Chromosome
    • Bp
    • Chr
  • gene
    • Human
    • Protein
    • Expression
    • Location
    • Chromosome
    • Methyltransferase
    • Bp
    • Chr
    • Prmt1
    • Activity
    • B3
    • Encodes
  • arginine
    • Protein
    • Gene
    • Enzyme
    • Methyltransferase
    • Prmt1
    • N-methyltransferase
    • Activity
    • Asymmetric
    • Encodes
    • Function
    • Functions
    • Hrmt1l2
  • histone methyltransferase
    • H4
    • Specific
    • Activity
    • Function
    • Pathway
    • Protein
    • Location
    • Methyltransferase
    • Chromosome
    • Bp
    • Chr
    • Human
  • histone h4
    • H4
    • Histone
    • Specific
    • Methyltransferase
    • Protein
    • Activity
    • Asymmetric
    • B3
    • End
    • Function
    • Hrmt1l2
    • Methylation
  • asymmetric dimethylarginine
    • Methylation
    • Prmt1
    • B3
    • Encodes
    • End
    • Function
    • Functions
    • Mouse
    • Pathway
    • Q99873
    • Specific
    • Uniprot

Connections between topic areas Semantic bridges

For PRMT1, one of the stronger structural bridges in this analysis connects PRMT1 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PRMT1Interactions · splits 11 ⟂ 12
PRMT1Overview · splits 16 ⟂ 7
PRMT1Reaction pathway · splits 20 ⟂ 3

Map overview Semantic statistics

PRMT1

Nodes23
Edges22
Triples123
Avg. degree1.91
Density0.086957
Components1

Source & methodology

TTTA analyzes the structure around PRMT1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Reaction pathway & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PRMT1 · EN edition · Analysis: TopicsToTalkAbout

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