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Nicotine

Nicotine is a stimulant and alkaloid found primarily in plants of the nightshade family, notably in tobacco; it is also synthesized. Nicotine is used recreationally for its stimulant and anxiolytic effects. In tobacco leaves, nicotine constitutes about 0.6–3.0% of the dry weight, and smaller, trace quantities occur in other Solanaceae crops such as…

History, Community, Culture & Applications

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Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
Addiction liability
Very high
AHFS/Drugs.com
Monograph
ATC code
N07BA01 (WHO) QP53AX13 (WHO)
Bioavailability
Inhalation: 80–90% · Intranasal: 60–80% · Transdermal: 68–100%
Boiling point
247 °C (477 °F)

Topics to explore

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Overview

Uses

Contraindications

Adverse effects

Overdose

Drug interactions

Pharmacology

Chemistry

Natural occurrence

History

Society and culture

Research

Advanced semantic analysis

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Map overview Semantic statistics

Nicotine

Nodes397
Edges396
Triples299
Avg. degree2
Density0.005038
Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

Nicotine

Top relations

related to history · 20
Nicotine → Adolf Pinner, Amé Pictet, Europe, French, French King, Germany, However, Its, Jean Nicot, Karl Ludwig Reimann, Melsens, Nicotiana, Paris, Portugal, Richard Wolffenstein, Rotschy, Smoking, Spanish, Villemain, Wilhelm Heinrich Posselt
related to Toxicity · 15
Nicotine → At, Green Tobacco Sickness, GTS, Health, Health Administration, More, NIOSH, Occupational Safety, OSHA, People, REL, The Occupational Safety, The US National Institute, This, Today
related to Immune system · 14
Nicotine → Although, As, E2, Evidence, IL-1, IL-17, IL-21, IL-22, IL-6, Immune, In, T-cells, TCR, TNF-α
related to Biosynthesis · 13
Nicotine → AO, Biosynthesis, Metabolic, N-methyl-Δ1-pyrrollidium, NAD, NaMN, Nicotiana, QPT, QS, Quinolinic, The, The NAD, This
related to Pesticide · 13
Nicotine → Between, Black Leaf, China, EU, Foods, IRAC, It, Neonicotinoids, They, This, United States, Unlike, US
related to Cancer · 12
Nicotine → Activation, Although, ARs, Contrary, Engineering, JAK-STAT, MAPK/ERK, Medicine, PI3K/AKT, Sciences, These, US National Academies
related to Overdose · 12
Nicotine → An, At, Drug Administration, FDA, It, LD50, Lethal, Nevertheless, OTC, OTC NRT, The, The US Food
related to Regulation · 12
Nicotine → Consolidated Appropriations Act, Drug Administration, Family Smoking Prevention, FDA, FDA's, Food, In, In March, The FDA, Tobacco Control Act, United States, US Congress
related to Cardiovascular system · 11
Nicotine → Additionally, Cigarette, Furthermore, In, Long-term, Many, NRT, Primarily, Short-term, The, This
related to Natural occurrence · 11
Nicotine → Duboisia, ETS, In, Manduca, Nicotiana, Others, Solanaceae, Solanaceaeous, Specialist, The, These

Important terminology Word statistics

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Important terminology

tobacco smoking effects use nicotinic may products used found also receptors form studies cigarettes synthetic dependence levels exposure associated acetylcholine

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Nicotine3D model (JSmol)Interactive image1.00infobox
NicotineAddiction liabilityVery high1.00infobox
NicotineAHFS/Drugs.comMonograph1.00infobox
NicotineATC codeN07BA01 (WHO) QP53AX13 (WHO)1.00infobox
NicotineBioavailabilityInhalation: 80–90%1.00infobox
NicotineBioavailabilityIntranasal: 60–80%1.00infobox
NicotineBioavailabilityTransdermal: 68–100%1.00infobox
NicotineBoiling point247 °C (477 °F)1.00infobox
NicotineCAS Number54-11-5 Y1.00infobox
NicotineChEBICHEBI:18723 Y1.00infobox
NicotineChEMBLChEMBL3 Y1.00infobox
NicotineChemSpider80863 Y1.00infobox
NicotineChiralityChiral1.00infobox
NicotineCompTox Dashboard (EPA)DTXSID10209301.00infobox
NicotineDensity1.01 g/cm31.00infobox
NicotineDependence liabilityPhysical: Low–moderate Psychological: High1.00infobox
NicotineDrug classNicotinic agonist; Stimulant; Nootropic; Euphoriant1.00infobox
NicotineDrugBankDB00184 Y1.00infobox
NicotineECHA InfoCard100.000.1771.00infobox
NicotineElimination half-life1–2 hours; 16–19 hours cotinine (range is 10–27 hours)1.00infobox
NicotineExcretionRenal, urine pH-dependent; 10–20% (gum), 30% (inhaled); 10–30% (intranasal)1.00infobox
NicotineFormulaC10H14N21.00infobox
NicotineIUPHAR/BPS25851.00infobox
NicotineKEGGD03365 Y1.00infobox
NicotineLegal statusAU: S7 (Dangerous drug)1.00infobox
NicotineLegal statusBR: Unscheduled1.00infobox
NicotineLegal statusCA: Unscheduled1.00infobox
NicotineLegal statusDE: Unscheduled1.00infobox
NicotineLegal statusNZ: Unscheduled1.00infobox
NicotineLegal statusUK: General sales list (GSL, OTC)1.00infobox

Related concept clusters Concept neighborhoods

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