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PITX2

Paired-like homeodomain transcription factor 2 also known as pituitary homeobox 2 is a protein that in humans is encoded by the PITX2 gene.

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Aliases
PITX2, ARP1, Brx1, IDG2, IGDS, IGDS2, IHG2, IRID2, Otlx2, PTX2, RGS, RIEG, RIEG1, RS, paired like homeodomain 2, ASGD4
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L7F, 2L7M, 2LKX
Band
4q25 · 3 G3|3 57.84 cM
Bgee
gums · biceps brachii · gingival epithelium · Skeletal muscle tissue of biceps brachii · muscle of thigh
BioGPS
More reference expression data
Chr.
Chromosome 4 (human) · Chromosome 3 (mouse)

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Overview

Function

Clinical significance

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Map overview Semantic statistics

PITX2

Nodes38
Edges37
Triples177
Avg. degree1.95
Density0.052632
Components1

How this topic connects Entity context

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PITX2

Top relations

Gene ontology · 82
PITX2 → anatomical structure morphogenesis, animal organ morphogenesis, atrial cardiac muscle tissue morphogenesis, atrioventricular valve development, brain development, branching involved in blood vessel morphogenesis, camera-type eye development, cardiac muscle cell differentiation, cardiac muscle tissue development, cardiac neural crest cell migration involved in outflow tract morphogenesis, cell proliferation involved in outflow tract morphogenesis, chromatin binding, chromatin DNA binding, cytoplasm, deltoid tuberosity development, determination of left/right symmetry, development of the heart, digestive system development, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific
Bgee · 20
PITX2 → abdominal wall, biceps brachii, body of tongue, gastrocnemius muscle, gingival epithelium, gums, labioscrotal swelling, lateral plate mesoderm, mammillary body, mesoderm, molar, muscle of thigh, pituitary gland, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, subthalamus, tooth, umbilical cord, vastus lateralis muscle, ventral tegmental area
RNA expression pattern · 20
PITX2 → abdominal wall, biceps brachii, body of tongue, gastrocnemius muscle, gingival epithelium, gums, labioscrotal swelling, lateral plate mesoderm, mammillary body, mesoderm, molar, muscle of thigh, pituitary gland, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, subthalamus, tooth, umbilical cord, vastus lateralis muscle, ventral tegmental area
related to Function · 14
PITX2 → ASE, Collectively, Expression, It, Nodal, Once, Pitx2a, Pitx2b, Pitx2c, RIEG/PITX, There, This, Three, When Pitx2
related to Clinical significance · 11
PITX2 → ARS, Axenfeld-Rieger, C-Myc, D1, D2, For, IGDS, Mutations, Peters, Scientists, This
related to External links · 6
PITX2 → Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, United States National Library
Band · 2
PITX2 → 3 G3|3 57.84 cM, 4q25
Chr. · 2
PITX2 → Chromosome 3 (mouse), Chromosome 4 (human)
End · 2
PITX2 → 110,642,123 bp, 129,013,240 bp
Aliases · 1
PITX2 → PITX2, ARP1, Brx1, IDG2, IGDS, IGDS2, IHG2, IRID2, Otlx2, PTX2, RGS, RIEG, RIEG1, RS, paired like homeodomain 2, ASGD4

Important terminology Word statistics

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Important terminology

expression gene development transcription myod protein cell human cells bp factor myogenesis pituitary chr band studies normal mice cancer also

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PITX2AliasesPITX2, ARP1, Brx1, IDG2, IGDS, IGDS2, IHG2, IRID2, Otlx2, PTX2, RGS, RIEG, RIEG1, RS, paired like homeodomain 2, ASGD41.00infobox
PITX2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2L7F, 2L7M, 2LKX1.00infobox
PITX2Band4q251.00infobox
PITX2Band3 G3|3 57.84 cM1.00infobox
PITX2Bgeegums1.00infobox
PITX2Bgeebiceps brachii1.00infobox
PITX2Bgeegingival epithelium1.00infobox
PITX2BgeeSkeletal muscle tissue of biceps brachii1.00infobox
PITX2Bgeemuscle of thigh1.00infobox
PITX2BgeeSkeletal muscle tissue of rectus abdominis1.00infobox
PITX2Bgeebody of tongue1.00infobox
PITX2Bgeegastrocnemius muscle1.00infobox
PITX2Bgeevastus lateralis muscle1.00infobox
PITX2Bgeepituitary gland1.00infobox
PITX2Bgeetooth1.00infobox
PITX2Bgeemolar1.00infobox
PITX2Bgeeumbilical cord1.00infobox
PITX2Bgeesubthalamus1.00infobox
PITX2Bgeemesoderm1.00infobox
PITX2Bgeelabioscrotal swelling1.00infobox
PITX2Bgeeabdominal wall1.00infobox
PITX2Bgeemammillary body1.00infobox
PITX2Bgeelateral plate mesoderm1.00infobox
PITX2Bgeeventral tegmental area1.00infobox
PITX2BioGPSMore reference expression data1.00infobox
PITX2Chr.Chromosome 4 (human)1.00infobox
PITX2Chr.Chromosome 3 (mouse)1.00infobox
PITX2DatabasesNCBI: entry; OMA: entry1.00infobox
PITX2End110,642,123 bp1.00infobox
PITX2End129,013,240 bp1.00infobox

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