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PER3: History & Research

The PER3 gene encodes the period circadian protein homolog 3 protein in humans. PER3 is a paralog to the PER1 and PER2 genes. It is a circadian gene associated with delayed sleep phase syndrome in humans.

Language: English [EN]
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PER3 topic overview

The analysis highlights History and Research as prominent areas in the source structure around PER3.

Related topics
24
Source areas
7
Connected nodes
31
Extracted relationships
141
Concept neighborhoods
17
Bridge connections
31

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 6 topics
Function · 5 topics
Clinical significance · 4 topics
Role in chronobiology · 4 topics
Animal studies · 2 topics
History · 2 topics
Gene · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
PER3, GIG13, FASPS3, period circadian clock 3, period circadian regulator 3
Band
1p36.23 · 4|4 E2
Bgee
sural nerve · parietal pleura · cerebellar vermis · tibia · cerebellar hemisphere
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 4 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

History

Function

Role in chronobiology

Animal studies

Clinical significance

Gene

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PER3 connects Entity context

The extracted context around PER3 shows recurring relationship patterns in the source. For example, PER3 → Achilles tendon, cerebellar hemisphere, cerebellar vermis, ciliary body, gastric mucosa, lacrimal gland, neural layer of retina, parietal pleura, primary oocyte, right hemisphere of cerebellum, Rostral migratory stream, saccule, secondary oocyte, Skeletal muscle tissue of rectus abdominis, skin of external ear, superior frontal gyrus, sural nerve, tibia, vestibular membrane of cochlear duct, visceral pleura Another extracted example is PER3 → circadian regulation of gene expression, circadian rhythm, cytoplasm, entrainment of circadian clock by photoperiod, kinase binding, negative regulation of transcription by RNA polymerase II, nucleus, protein binding, protein stabilization, regulation of circadian sleep/wake cycle, sleep, regulation of transcription, DNA-templated, response to light stimulus, rhythmic process, transcription cis-regulatory region binding, transcription corepressor binding, transcription factor binding, transcription, DNA-templated, ubiquitin protein ligase binding. Use these groups to spot repeated connection types before inspecting the individual relationships.

PER3

Top relations

Bgee · 20
PER3 → Achilles tendon, cerebellar hemisphere, cerebellar vermis, ciliary body, gastric mucosa, lacrimal gland, neural layer of retina, parietal pleura, primary oocyte, right hemisphere of cerebellum, Rostral migratory stream, saccule, secondary oocyte, Skeletal muscle tissue of rectus abdominis, skin of external ear, superior frontal gyrus, sural nerve, tibia, vestibular membrane of cochlear duct, visceral pleura
RNA expression pattern · 20
PER3 → Achilles tendon, cerebellar hemisphere, cerebellar vermis, ciliary body, gastric mucosa, lacrimal gland, neural layer of retina, parietal pleura, primary oocyte, right hemisphere of cerebellum, Rostral migratory stream, saccule, secondary oocyte, Skeletal muscle tissue of rectus abdominis, skin of external ear, superior frontal gyrus, sural nerve, tibia, vestibular membrane of cochlear duct, visceral pleura
Gene ontology · 18
PER3 → circadian regulation of gene expression, circadian rhythm, cytoplasm, entrainment of circadian clock by photoperiod, kinase binding, negative regulation of transcription by RNA polymerase II, nucleus, protein binding, protein stabilization, regulation of circadian sleep/wake cycle, sleep, regulation of transcription, DNA-templated, response to light stimulus, rhythmic process, transcription cis-regulatory region binding, transcription corepressor binding, transcription factor binding, transcription, DNA-templated, ubiquitin protein ligase binding
related to Role in chronobiology · 11
PER3 → However, Likely, PAS, Per1, PER1/2, Per2, SCN, The, The RNA, This, Unlike Per1
related to Function · 9
PER3 → Circadian, Genes, It, PER1, PER2, PER3-P415A/H417R, Period, SCN, This
related to history · 9
PER3 → Harvard Medical School, June, Kobe University School, Medicine, PER, Per2, PERIOD3, The, The Per3
related to Clinical significance · 7
PER3 → AB047686, Additionally, GenBank, T2DM, The, The PER3, The PER3-P415A/H417R
related to Post translational modifications · 7
PER3 → CSNK1E, Modification, PER1, Phosphorylation, PhosphoSitePlusModification, The, Ubiquitinated
related to Animal studies · 6
PER3 → Functional Per3, Furthermore, PER1, Per1-/-Per2, PER2, While
related to External links · 6
PER3 → Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, United States National Library

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

circadian gene per1 per2 bp protein human clock polymorphism light period chr band location mper3 chromosome sleep scn genes mice

PER3 relationships Subject–Predicate–Object triples

TTTA extracted 141 structured relationships around PER3. Examples in this analysis include PER3 → Aliases → PER3, GIG13, FASPS3, period circadian clock 3, period circadian regulator 3 and PER3 → Band → 1p36.23. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PER3AliasesPER3, GIG13, FASPS3, period circadian clock 3, period circadian regulator 31.00infobox
PER3Band1p36.231.00infobox
PER3Band4|4 E21.00infobox
PER3Bgeesural nerve1.00infobox
PER3Bgeeparietal pleura1.00infobox
PER3Bgeecerebellar vermis1.00infobox
PER3Bgeetibia1.00infobox
PER3Bgeecerebellar hemisphere1.00infobox
PER3BgeeAchilles tendon1.00infobox
PER3Bgeeright hemisphere of cerebellum1.00infobox
PER3Bgeevisceral pleura1.00infobox
PER3Bgeegastric mucosa1.00infobox
PER3BgeeSkeletal muscle tissue of rectus abdominis1.00infobox
PER3Bgeeciliary body1.00infobox
PER3Bgeevestibular membrane of cochlear duct1.00infobox
PER3Bgeeneural layer of retina1.00infobox
PER3Bgeesaccule1.00infobox
PER3BgeeRostral migratory stream1.00infobox
PER3Bgeeprimary oocyte1.00infobox
PER3Bgeeskin of external ear1.00infobox
PER3Bgeesuperior frontal gyrus1.00infobox
PER3Bgeelacrimal gland1.00infobox
PER3Bgeesecondary oocyte1.00infobox
PER3BioGPSMore reference expression data1.00infobox
PER3Chr.Chromosome 1 (human)1.00infobox
PER3Chr.Chromosome 4 (mouse)1.00infobox
PER3DatabasesNCBI: entry; OMA: entry1.00infobox
PER3End7,845,177 bp1.00infobox
PER3End151,044,665 bp1.00infobox
PER3EnsemblENSG000000492461.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PER3 bring nearby vocabulary together. In this analysis, examples include Per1, Per2 and Circadian. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • PER3
    • Per1
    • Per2
    • Circadian
    • Clock
    • Light
    • Protein
    • May
    • Mice
    • Human
    • Period
    • Function
    • Knockout
  • per3
    • Per1
    • Per2
    • Circadian
    • Clock
    • Light
    • Protein
    • May
    • Mice
    • Human
    • Period
    • Function
    • Knockout
  • gene
    • Location
    • Chromosome
    • Circadian
    • Bp
    • Human
    • Protein
    • Orthologs
    • Chr
    • Per3
    • Period
    • External
    • Expression
  • delayed sleep phase syndrome
    • Delayed
    • Phase
    • Syndrome
    • Sleep
    • Associated
    • Humans
    • Polymorphism
    • External
    • Expression
    • Function
    • Mouse
    • Nucleus
  • circadian
    • Gene
    • Per3
    • Clock
    • Scn
    • Light
    • Expression
    • Function
    • Rhythms
    • Mper3
    • Protein
    • External
    • Per1
  • circadian rhythms
    • Gene
    • Per3
    • Clock
    • Genes
    • Scn
    • Light
    • Expression
    • Function
    • Circadian
    • Rhythms
    • Paralog
    • Mper3
  • circadian clock
    • Function
    • External
    • Gene
    • Orthologs
    • Per3
    • Clock
    • Location
    • Scn
    • Shown
    • Chr
    • Chromosome
    • Light
  • familial advanced sleep phase syndrome
    • Delayed
    • Phase
    • Syndrome
    • Sleep
    • Associated
    • Humans
    • Polymorphism
    • External
    • Expression
    • Function
    • Mouse
    • Nucleus

Connections between topic areas Semantic bridges

For PER3, one of the stronger structural bridges in this analysis connects PER3 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PER3Overview · splits 25 ⟂ 7
PER3Function · splits 26 ⟂ 6
PER3Role in chronobiology · splits 27 ⟂ 5
PER3Clinical significance · splits 27 ⟂ 5
PER3History · splits 29 ⟂ 3
PER3Animal studies · splits 29 ⟂ 3

Map overview Semantic statistics

PER3

Nodes32
Edges31
Triples141
Avg. degree1.94
Density0.0625
Components1

Source & methodology

TTTA analyzes the structure around PER3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Research, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PER3 · EN edition · Analysis: TopicsToTalkAbout

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