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PDX1

PDX1 (pancreatic and duodenal homeobox 1), also known as insulin promoter factor 1, is a transcription factor in the ParaHox gene cluster. In vertebrates, Pdx1 is necessary for pancreatic development, including β-cell maturation, and duodenal differentiation. In humans this protein is encoded by the PDX1 gene, which was formerly known as IPF1. The gene…

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Aliases
PDX1, GSF, IDX-1, IPF1, IUF1, MODY4, PAGEN1, PDX-1, STF-1, pancreatic and duodenal homeobox 1
Band
13q12.2 · 5 G3|5 86.84 cM
Bgee
islet of Langerhans · body of pancreas · duodenum · gallbladder · liver
BioGPS
More reference expression data
Chr.
Chromosome 13 (human) · Chromosome 5 (mouse)
Databases
NCBI: entry; OMA: entry

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PDX1

Nodes51
Edges50
Triples175
Avg. degree1.96
Density0.039216
Components1

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PDX1

Top relations

Gene ontology · 69
PDX1 → animal organ morphogenesis, animal organ regeneration, cell differentiation, central nervous system development, chromatin binding, cytoplasm, cytosol, detection of glucose, digestive tract development, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, endocrine pancreas development, exocrine pancreas development, generation of precursor metabolites and energy, glucose homeostasis, glucose metabolic process, insulin secretion, intracellular anatomical structure, liver development
related to Pancreatic development · 19
PDX1 → Afterwards, E12, E8, FGF-10, Hlxb9, Hnf6, Homozygous Pdx1, In, Langerhans, Ngn3, NKX6-1, Notch, Other, Pancreatic Pdx1, PP, Ptf1a, The, These, This Ngn3
Bgee · 18
PDX1 → body of pancreas, body of stomach, duodenum, endocrine pancreas, gallbladder, humerus, islet of Langerhans, kidney, liver, Meckel's cartilage, mucous cell of stomach, pancreatic bud, primary oocyte, primordial pancreas, pyloric antrum, rectum, right lobe of liver, stomach
RNA expression pattern · 18
PDX1 → body of pancreas, body of stomach, duodenum, endocrine pancreas, gallbladder, humerus, islet of Langerhans, kidney, liver, Meckel's cartilage, mucous cell of stomach, pancreatic bud, primary oocyte, primordial pancreas, pyloric antrum, rectum, right lobe of liver, stomach
related to External links · 8
PDX1 → GeneReviews/NCBI/NIH/UW, Medicine, Medicine Medical Subject Headings, MeSH, National Library, Permanent Neonatal Diabetes MellitusPDX1, This, United States National Library
related to β-cell maturation and survival · 8
PDX1 → At, For, Furthermore, In, MafA, MafB, NKX6-1, The
related to Duodenum · 7
PDX1 → Brunner's, Cdx2, Duodenal, In, It, ParaHox, Sox2
related to Pathology · 7
PDX1 → Diabetes, Experiments, Furthermore, Maturity, Psammomys, The, Type
Band · 2
PDX1 → 13q12.2, 5 G3|5 86.84 cM
Chr. · 2
PDX1 → Chromosome 13 (human), Chromosome 5 (mouse)

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Important terminology

pancreatic gene cells expression development bp human β-cells chr band duodenal pancreas differentiation insulin chromosome 13 endocrine duodenum identified β-cell

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PDX1AliasesPDX1, GSF, IDX-1, IPF1, IUF1, MODY4, PAGEN1, PDX-1, STF-1, pancreatic and duodenal homeobox 11.00infobox
PDX1Band13q12.21.00infobox
PDX1Band5 G3|5 86.84 cM1.00infobox
PDX1Bgeeislet of Langerhans1.00infobox
PDX1Bgeebody of pancreas1.00infobox
PDX1Bgeeduodenum1.00infobox
PDX1Bgeegallbladder1.00infobox
PDX1Bgeeliver1.00infobox
PDX1Bgeerectum1.00infobox
PDX1Bgeeright lobe of liver1.00infobox
PDX1Bgeestomach1.00infobox
PDX1Bgeekidney1.00infobox
PDX1Bgeebody of stomach1.00infobox
PDX1Bgeeprimordial pancreas1.00infobox
PDX1Bgeeendocrine pancreas1.00infobox
PDX1Bgeepancreatic bud1.00infobox
PDX1Bgeepyloric antrum1.00infobox
PDX1Bgeehumerus1.00infobox
PDX1BgeeMeckel's cartilage1.00infobox
PDX1Bgeeprimary oocyte1.00infobox
PDX1Bgeemucous cell of stomach1.00infobox
PDX1BioGPSMore reference expression data1.00infobox
PDX1Chr.Chromosome 13 (human)1.00infobox
PDX1Chr.Chromosome 5 (mouse)1.00infobox
PDX1DatabasesNCBI: entry; OMA: entry1.00infobox
PDX1End27,926,313 bp1.00infobox
PDX1End147,212,658 bp1.00infobox
PDX1EnsemblENSG000001395151.00infobox
PDX1Entrez36511.00infobox
PDX1External IDsOMIM: 600733; MGI: 102851; GeneCards: PDX11.00infobox

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