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Cytochrome P450

Cytochromes P450 (P450s or CYPs) are a superfamily of enzymes containing heme as a cofactor that mostly, but not exclusively, function as monooxygenases. However, they are not omnipresent; for example, they have not been found in Escherichia coli. In mammals, these enzymes oxidize steroids, fatty acids, xenobiotics, and participate in many biosyntheses.…

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Key facts & relationships

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AlphaFold
IPR001128 · PF00067
Available protein structures:
IPR001128 · PF00067
CDD
cd00302
InterPro
IPR001128
Membranome
265
OPM protein
2bdm

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Overview

Classification

Mechanism

Other hydroxylation enzymes

Advanced semantic analysis

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Map overview Semantic statistics

Cytochrome P450

Nodes70
Edges69
Triples121
Avg. degree1.97
Density0.028571
Components1

How this topic connects Entity context

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Cytochrome P450

Top relations

related to By electron transfer system · 29
Cytochrome P450 → Also, Bacillus, Based, CAM, CPR, CPR-P450, CYB5R, CYB5R/cyb5/P450, CYP, CYP101A1, CYP106A2, CYP5, CYP74A, CYP8, CYPOR, FMN-domain-containing, FMN/Fd/P450, Fr/Fd/P450, Microsomal P450, Mitochondrial P450
related to Nomenclature · 24
Cytochrome P450 → A2, CYP, CYP Allele Nomenclature Committee, CYP102A1, CYP2E1, CYP450, CYP51A1, CYP5A1, Cytochrome P450 Homepage Archived, Examples, For, Genes, However, LDM, Nomenclature, P450, P450BM3, P450s, Sometimes, TBXAS1
related to Catalytic cycle · 16
Cytochrome P450 → After, Compound, Depending, Evidence, Fe, Fe-O2, II, III, IV, Molecular, NAD, P450, P450 Compound, Substrate, The, This
related to Further reading · 13
Cytochrome P450 → December, Disposition, Drug Metabolism, Estabrook RW, Lock-gray-alt-2, Lock-green, Lock-red-alt-2, P450, P450s, PMID, Remembrances, S2CID, Wikisource-logo
related to Structure · 12
Cytochrome P450 → FW, GAD, GD, In, LIVMFAP, P450, P450s, PROSITE, RKHPT, SGNH, The, This
related to Binding site · 8
Cytochrome P450 → Additional, AGxDTT, ExxR, FxxGxRxCxG, I-helix, K-helix, P450, The
AlphaFold · 2
Cytochrome P450 → IPR001128, PF00067
Available protein structures: · 2
Cytochrome P450 → IPR001128, PF00067
see also · 2
Cytochrome P450 → Biology, P450
CDD · 1
Cytochrome P450 → cd00302

Important terminology Word statistics

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Important terminology

p450 enzymes p450s reductase iron heme cytochrome systems substrate transfer electrons cyp reduced family found enzyme one nomenclature also electron

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Cytochrome P450AlphaFoldIPR0011281.00infobox
Cytochrome P450AlphaFoldPF000671.00infobox
Cytochrome P450Available protein structures:IPR0011281.00infobox
Cytochrome P450Available protein structures:PF000671.00infobox
Cytochrome P450CDDcd003021.00infobox
Cytochrome P450InterProIPR0011281.00infobox
Cytochrome P450Membranome2651.00infobox
Cytochrome P450OPM protein2bdm1.00infobox
Cytochrome P450OPM superfamily391.00infobox
Cytochrome P450PDBIPR001128 PF00067 (ECOD; PDBsum)1.00infobox
Cytochrome P450PfamPF000671.00infobox
Cytochrome P450PROSITEPDOC000811.00infobox
Cytochrome P450SCOP22cpp / SCOPe / SUPFAM1.00infobox
Cytochrome P450Symbolp4501.00infobox

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    Min side: 3
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