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Optogenetics

Optogenetics is a biological technique used to characterize and manipulate the activity of neurons or other cell types with light. This is achieved by expression of light-sensitive ion channels, pumps or enzymes in the target brain cells. A specialization of this field is nano-optogenetics.

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Overview

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Description

Technique

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Awards

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Optogenetics

Nodes147
Edges146
Triples101
Avg. degree1.99
Density0.013605
Components1

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Optogenetics

Top relations

related to Awards · 24
Optogenetics → Additionally, Baillet Latour Health Prize, Bamberg, Biomedical Sciences, Breakthroughs, Decade, Deisseroth, Ernst Bamberg, Georg Nagel, Hegemann, HFSP Nakasone Award, In, Karl Deisseroth, Karl Heinz Beckurts Prize, Max Planck Society, Method, Miesenböck, Nagel, Nature Methods, Peter Hegemann
related to Technique · 12
Optogenetics → BiPOLES, By, CAMKIIα, Cation-selective, ChR2, Combining, Cre, GtACR2, Introducing, One, The, This
related to Cellular biology/cell signaling pathways · 8
Optogenetics → Analogously, By, Directed, DNA-binding, In, PIF, The, This
related to Selective expression · 7
Optogenetics → Due, In, Mathematical, One, Optogenetic, Restricting, Thus
has application · 5
Optogenetics → An, On, Parkinson's, Schizophrenia, The
related to Description · 5
Optogenetics → Beyond, Figure, Light-activated, These, This
related to External links · 4
Optogenetics → April, Inscopix, Integrated Calcium Imaging, Scientifica
is a · 2
Optogenetics → biological technique used to characterize and manipulate the activity of neurons or other cell types with light, introduction of fast light-activated channels

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Important terminology

neurons light optogenetic used cells activity control activation brain also neuronal using mice stimulation neural optical specific channels allow expression

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Optogeneticsis abiological technique used to characterize and manipulate the activity of neurons or other cell types with light0.90text
Optogeneticsis aintroduction of fast light-activated channels0.90text
cAMPinstance ofBuilding on prior work fusing vertebrate opsins to specific G-protein coupled receptors a family of chimeric single-component optogenetic tools was created that allowed research…0.80text
IP3 in targeted cellsinstance ofBuilding on prior work fusing vertebrate opsins to specific G-protein coupled receptors a family of chimeric single-component optogenetic tools was created that allowed research…0.80text
the cerebral cortexinstance ofTo stimulate superficial brain areas0.80text
optical fibers or LEDs can be directly mounted to the skull of the animalinstance ofTo stimulate superficial brain areas0.80text
cell-specific promoters or other customized conditionally-active viruses to deliver light-sensitive probes to specific populations of neurons in the brain of living animalsinstance ofcompletely wireless techniques have been developed utilizing wirelessly delivered power to headborne Light-emitting diodes LEDs for unhindered study of complex behaviors in free…0.80text
wormsinstance ofIn invertebrates0.80text
fruit flies some amount of all-trans-retinalinstance ofIn invertebrates0.80text
dendritesinstance ofRestricting the opsin to specific regions of the plasma membrane0.80text
somata or axon terminals provides a more robust understanding of neuronal circuitry.Mathematical modelling shows that selective expression of opsin in specific cell types can dramatically alter the dynamical behavior of the neural circuitryinstance ofRestricting the opsin to specific regions of the plasma membrane0.80text
neural circuits in vivoinstance ofApplicationsThe field of optogenetics has furthered the fundamental scientific understanding of how specific cell types contribute to the function of biological tissues0.80text

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